STRINGSTRING
MDM2 MDM2 ERBB2 ERBB2 CSDE1 CSDE1 KRAS KRAS TYMP TYMP CDKN2A CDKN2A NRAS NRAS DAPK1 DAPK1 MAP2K2 MAP2K2 E2F3 E2F3 FGFR3 FGFR3 THBS1 THBS1 E2F2 E2F2 VEGFA VEGFA CCND1 CCND1 RAF1 RAF1 CDH1 CDH1 HRAS HRAS TP53 TP53 RPS6KA5 RPS6KA5 DAPK2 DAPK2 ENSMNEP00000027902 ENSMNEP00000027902 MMP9 MMP9 CXCL8 CXCL8 MMP1 MMP1 DAPK3 DAPK3 EGF EGF ARAF ARAF ENSMNEP00000016378 ENSMNEP00000016378 CDK4 CDK4 MAPK3 MAPK3 MMP2 MMP2 RB1 RB1 MAPK1 MAPK1 RASSF1 RASSF1 UPK3A UPK3A HBEGF HBEGF MAP2K1 MAP2K1 SRC SRC E2F1 E2F1 BRAF BRAF EGFR EGFR MYC MYC CDKN1A CDKN1A ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
E2F3E2F transcription factor 3. (465 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
THBS1Thrombospondin 1. (1173 aa)
E2F2E2F transcription factor 2. (439 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (452 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
MMP9Matrix metallopeptidase 9. (694 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
DAPK3Death associated protein kinase 3. (429 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
RASSF1Ras association domain family member 1. (340 aa)
UPK3AUroplakin 3A. (287 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
SRCTyrosine-protein kinase. (644 aa)
E2F1E2F transcription factor 1. (437 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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