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MANE-B MANE-B IL2 IL2 LOC105467297 LOC105467297 ENSMNEP00000000821 ENSMNEP00000000821 IFNA6 IFNA6 ENSMNEP00000001351 ENSMNEP00000001351 HLA-G HLA-G HLA-DOA HLA-DOA IL5 IL5 CD40 CD40 ENSMNEP00000002245 ENSMNEP00000002245 HLA-DRA HLA-DRA ENSMNEP00000004521 ENSMNEP00000004521 LOC105470433 LOC105470433 PRF1 PRF1 FAS FAS ENSMNEP00000007368 ENSMNEP00000007368 LOC105466472 LOC105466472 CD80 CD80 ENSMNEP00000010486 ENSMNEP00000010486 ENSMNEP00000010506 ENSMNEP00000010506 TG TG HLA-DPB1 HLA-DPB1 GZMB GZMB ENSMNEP00000013138 ENSMNEP00000013138 ENSMNEP00000013313 ENSMNEP00000013313 CD86 CD86 HLA-DMA HLA-DMA ENSMNEP00000018745 ENSMNEP00000018745 TSHR TSHR CD28 CD28 LOC105470432 LOC105470432 IL4 IL4 ENSMNEP00000020833 ENSMNEP00000020833 ENSMNEP00000021289 ENSMNEP00000021289 LOC105469851 LOC105469851 ENSMNEP00000023427 ENSMNEP00000023427 ENSMNEP00000023924 ENSMNEP00000023924 ENSMNEP00000025520 ENSMNEP00000025520 SYCP1 SYCP1 MANE-E MANE-E ENSMNEP00000028604 ENSMNEP00000028604 LOC105498418 LOC105498418 ENSMNEP00000029248 ENSMNEP00000029248 TRAC TRAC HLA-DQA1 HLA-DQA1 CD40LG CD40LG HLA-F HLA-F ENSMNEP00000033181 ENSMNEP00000033181 TRAV22 TRAV22 FASLG FASLG ENSMNEP00000035333 ENSMNEP00000035333 HLA-DPA1 HLA-DPA1 IL10 IL10 IFNA14 IFNA14 ENSMNEP00000037129 ENSMNEP00000037129 TSHB TSHB ENSMNEP00000038649 ENSMNEP00000038649 ENSMNEP00000040169 ENSMNEP00000040169 LOC105498430 LOC105498430 HLA-DOB HLA-DOB CTLA4 CTLA4 TPO TPO LOC105474413 LOC105474413 ENSMNEP00000043350 ENSMNEP00000043350 LOC105474426 LOC105474426 CGA CGA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MANE-BIg-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
LOC105467297Ig-like domain-containing protein; Belongs to the MHC class I family. (242 aa)
ENSMNEP00000000821Ig-like domain-containing protein. (143 aa)
IFNA6Interferon alpha 6. (190 aa)
ENSMNEP00000001351Ig-like domain-containing protein. (151 aa)
HLA-GIGc1 domain-containing protein; Belongs to the MHC class I family. (354 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CD40CD40 molecule. (278 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
LOC105470433MHC class II antigen. (260 aa)
PRF1Perforin. (555 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
ENSMNEP00000007368MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (168 aa)
LOC105466472Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
CD80CD80 molecule. (288 aa)
ENSMNEP00000010486Ig-like domain-containing protein. (133 aa)
ENSMNEP00000010506Ig-like domain-containing protein. (142 aa)
TGThyroglobulin. (2769 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
ENSMNEP00000013138Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
ENSMNEP00000013313Uncharacterized protein. (152 aa)
CD86CD86 molecule. (329 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
ENSMNEP00000018745Ig-like domain-containing protein; Belongs to the MHC class I family. (317 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
CD28CD28 molecule. (220 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSMNEP00000020833Ig-like domain-containing protein. (145 aa)
ENSMNEP00000021289Ig-like domain-containing protein. (182 aa)
LOC105469851Ig-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
ENSMNEP00000023427Uncharacterized protein. (198 aa)
ENSMNEP00000023924MHC_I-like_Ag-recog domain-containing protein. (162 aa)
ENSMNEP00000025520Ig-like domain-containing protein. (194 aa)
SYCP1Synaptonemal complex protein 1. (976 aa)
MANE-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
ENSMNEP00000028604IGv domain-containing protein. (139 aa)
LOC105498418Uncharacterized protein. (190 aa)
ENSMNEP00000029248MHC_I-like_Ag-recog domain-containing protein. (172 aa)
TRACT cell receptor alpha constant. (110 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (440 aa)
ENSMNEP00000033181Ig-like domain-containing protein; Belongs to the MHC class I family. (393 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
ENSMNEP00000035333Ig-like domain-containing protein; Belongs to the MHC class I family. (356 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IFNA14Interferon alpha 14. (137 aa)
ENSMNEP00000037129Ig-like domain-containing protein. (346 aa)
TSHBThyroid stimulating hormone subunit beta. (158 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
ENSMNEP00000040169Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
LOC105498430Uncharacterized protein. (189 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
CTLA4CD152 protein. (223 aa)
TPOThyroid peroxidase. (926 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
ENSMNEP00000043350Ig-like domain-containing protein. (233 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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