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IL18 IL18 TGFB1 TGFB1 IFNGR1 IFNGR1 IL18R1 IL18R1 ENSMNEP00000038649 ENSMNEP00000038649 IL10 IL10 IL21R IL21R IL23R IL23R RORC RORC IL17A IL17A HLA-DPA1 HLA-DPA1 TLR4 TLR4 IL1A IL1A TRAV22 TRAV22 IL1B IL1B IL17F IL17F HLA-DQA1 HLA-DQA1 TRAC TRAC TNF TNF ENSMNEP00000028604 ENSMNEP00000028604 RELA RELA IL18RAP IL18RAP SMAD2 SMAD2 MAF MAF TBX21 TBX21 IL23A IL23A FOXP3 FOXP3 IFNGR2 IFNGR2 STAT4 STAT4 IL4 IL4 LOC105470432 LOC105470432 IL12B IL12B STAT3 STAT3 SMAD3 SMAD3 HLA-DMA HLA-DMA IL12RB2 IL12RB2 NOD2 NOD2 IL4R IL4R IL2RG IL2RG IL21 IL21 NFKB1 NFKB1 HLA-DPB1 HLA-DPB1 IL22 IL22 ENSMNEP00000010486 ENSMNEP00000010486 IL12RB1 IL12RB1 LOC105470433 LOC105470433 RORA RORA ENSMNEP00000004521 ENSMNEP00000004521 IL13 IL13 HLA-DRA HLA-DRA NFATC1 NFATC1 ENSMNEP00000002245 ENSMNEP00000002245 IL5 IL5 HLA-DOA HLA-DOA TLR2 TLR2 STAT1 STAT1 IL6 IL6 IL2 IL2 STAT6 STAT6 IFNG IFNG LOC105474426 LOC105474426 GATA3 GATA3 LOC105474413 LOC105474413 IL12A IL12A HLA-DOB HLA-DOB TGFB3 TGFB3 TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL21RInterleukin 21 receptor. (538 aa)
IL23RInterleukin 23 receptor. (576 aa)
RORCRAR related orphan receptor C. (518 aa)
IL17AInterleukin 17A. (155 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IL17FInterleukin 17F. (163 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
TRACT cell receptor alpha constant. (110 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSMNEP00000028604IGv domain-containing protein. (139 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (340 aa)
TBX21T-box transcription factor 21. (535 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
FOXP3Forkhead box P3. (456 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (842 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL4RInterleukin 4 receptor. (825 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
IL22Interleukin 22. (179 aa)
ENSMNEP00000010486Ig-like domain-containing protein. (133 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
LOC105470433MHC class II antigen. (260 aa)
RORARAR related orphan receptor A. (555 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
IL13Interleukin 13. (146 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
NFATC1Nuclear factor of activated T cells 1. (988 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
TLR2Toll-like receptor. (784 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IL6Interleukin 6. (214 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
GATA3GATA binding protein 3. (444 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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