STRINGSTRING
ENSMNEP00000007368 ENSMNEP00000007368 IFNG IFNG LOC105474426 LOC105474426 ENSMNEP00000043350 ENSMNEP00000043350 LOC105474413 LOC105474413 IL12A IL12A HLA-DOB HLA-DOB ENSMNEP00000040169 ENSMNEP00000040169 ENSMNEP00000038649 ENSMNEP00000038649 ENSMNEP00000037129 ENSMNEP00000037129 IL10 IL10 HLA-DPA1 HLA-DPA1 ENSMNEP00000035333 ENSMNEP00000035333 FASLG FASLG TRAV22 TRAV22 ENSMNEP00000033181 ENSMNEP00000033181 HLA-F HLA-F CD40LG CD40LG HLA-DQA1 HLA-DQA1 TRAC TRAC ENSMNEP00000029248 ENSMNEP00000029248 TNF TNF ENSMNEP00000028604 ENSMNEP00000028604 MANE-E MANE-E ENSMNEP00000025520 ENSMNEP00000025520 ENSMNEP00000023924 ENSMNEP00000023924 LOC105469851 LOC105469851 ENSMNEP00000021289 ENSMNEP00000021289 ENSMNEP00000020833 ENSMNEP00000020833 IL4 IL4 LOC105470432 LOC105470432 IL12B IL12B CD28 CD28 ENSMNEP00000018745 ENSMNEP00000018745 HLA-DMA HLA-DMA CD86 CD86 ENSMNEP00000013138 ENSMNEP00000013138 GZMB GZMB HLA-DPB1 HLA-DPB1 ENSMNEP00000010506 ENSMNEP00000010506 ENSMNEP00000010486 ENSMNEP00000010486 CD80 CD80 LOC105466472 LOC105466472 FAS FAS PRF1 PRF1 LOC105470433 LOC105470433 ENSMNEP00000004521 ENSMNEP00000004521 HLA-DRA HLA-DRA ENSMNEP00000002245 ENSMNEP00000002245 CD40 CD40 IL5 IL5 HLA-DOA HLA-DOA HLA-G HLA-G ENSMNEP00000001351 ENSMNEP00000001351 ENSMNEP00000000821 ENSMNEP00000000821 LOC105467297 LOC105467297 IL2 IL2 MANE-B MANE-B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000007368MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (168 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
LOC105474426Ig-like domain-containing protein. (263 aa)
ENSMNEP00000043350Ig-like domain-containing protein. (233 aa)
LOC105474413Ig-like domain-containing protein. (295 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (285 aa)
ENSMNEP00000040169Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
ENSMNEP00000038649Ig-like domain-containing protein. (235 aa)
ENSMNEP00000037129Ig-like domain-containing protein. (346 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ENSMNEP00000035333Ig-like domain-containing protein; Belongs to the MHC class I family. (356 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
ENSMNEP00000033181Ig-like domain-containing protein; Belongs to the MHC class I family. (393 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (440 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (267 aa)
TRACT cell receptor alpha constant. (110 aa)
ENSMNEP00000029248MHC_I-like_Ag-recog domain-containing protein. (172 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSMNEP00000028604IGv domain-containing protein. (139 aa)
MANE-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
ENSMNEP00000025520Ig-like domain-containing protein. (194 aa)
ENSMNEP00000023924MHC_I-like_Ag-recog domain-containing protein. (162 aa)
LOC105469851Ig-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
ENSMNEP00000021289Ig-like domain-containing protein. (182 aa)
ENSMNEP00000020833Ig-like domain-containing protein. (145 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
LOC105470432Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CD28CD28 molecule. (220 aa)
ENSMNEP00000018745Ig-like domain-containing protein; Belongs to the MHC class I family. (317 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
CD86CD86 molecule. (329 aa)
ENSMNEP00000013138Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
ENSMNEP00000010506Ig-like domain-containing protein. (142 aa)
ENSMNEP00000010486Ig-like domain-containing protein. (133 aa)
CD80CD80 molecule. (288 aa)
LOC105466472Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
PRF1Perforin. (555 aa)
LOC105470433MHC class II antigen. (260 aa)
ENSMNEP00000004521Ig-like domain-containing protein. (230 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
CD40CD40 molecule. (278 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-GIGc1 domain-containing protein; Belongs to the MHC class I family. (354 aa)
ENSMNEP00000001351Ig-like domain-containing protein. (151 aa)
ENSMNEP00000000821Ig-like domain-containing protein. (143 aa)
LOC105467297Ig-like domain-containing protein; Belongs to the MHC class I family. (242 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
MANE-BIg-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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