(75 nodes) Mixed, incl. Tyrosine metabolism, and Tryptophan catabolism network (Papio anubis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ESD	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
	AADACL4	Arylacetamide deacetylase like 4. (407 aa)
	AOC1	Amine oxidase. (755 aa)
	DBH	Dopamine beta-hydroxylase. (620 aa)
	ENSPANP00000002970	Uncharacterized protein. (378 aa)
	AADAT	Aminoadipate aminotransferase. (421 aa)
	DDC	Dopa decarboxylase. (480 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (463 aa)
	BTBD8	BTB domain containing 8. (1411 aa)
	CARNS1	Carnosine synthase 1. (950 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (374 aa)
	FAHD2A	Fumarylacetoacetate hydrolase domain containing 2A. (369 aa)
	ALDH8A1	Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
	ASMT	Acetylserotonin O-methyltransferase. (304 aa)
	CDO1	Cysteine dioxygenase. (200 aa)
	HACL1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (578 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	TPH2	Tryptophan hydroxylase 2. (496 aa)
	CNDP2	Carnosine dipeptidase 2. (475 aa)
	LOC101018671	PKS_ER domain-containing protein. (369 aa)
	HGD	Homogentisate 1,2-dioxygenase. (445 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (285 aa)
	ADHFE1	Fe-ADH domain-containing protein. (467 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (420 aa)
	EPHX4	Epoxide hydrolase 4. (362 aa)
	ENSPANP00000008413	FAA_hydrolase domain-containing protein. (302 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (403 aa)
	LRTOMT	Uncharacterized protein. (302 aa)
	ALDH3B2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
	CSAD	Cysteine sulfinic acid decarboxylase. (515 aa)
	KYAT3	Kynurenine aminotransferase 3. (453 aa)
	ADO	2-aminoethanethiol dioxygenase. (229 aa)
	AADACL3	Arylacetamide deacetylase like 3. (407 aa)
	HPD	4-hydroxyphenylpyruvate dioxygenase. (393 aa)
	ASMTL	Acetylserotonin O-methyltransferase like. (476 aa)
	FAH	Fumarylacetoacetase. (427 aa)
	ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (394 aa)
	TDO2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (465 aa)
	AANAT	Aralkylamine N-acetyltransferase. (246 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (308 aa)
	FAHD2B	Fumarylacetoacetate hydrolase domain containing 2B. (207 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	KYAT1	Aminotran_1_2 domain-containing protein. (515 aa)
	MAOA	Amine oxidase. (527 aa)
	MAOB	Amine oxidase. (504 aa)
	CARNMT1	Carnosine N-methyltransferase 1. (409 aa)
	CENPV	Centromere protein V. (274 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (331 aa)
	AOC2	Amine oxidase. (756 aa)
	AOC3	Amine oxidase. (764 aa)
	DDTL	D-dopachrome tautomerase like. (131 aa)
	IL4I1	Amine oxidase. (589 aa)
	CNDP1	Carnosine dipeptidase 1. (548 aa)
	GAD2	Glutamate decarboxylase 2. (591 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (533 aa)
	ENSPANP00000025360	Uncharacterized protein. (311 aa)
	LOC101016817	Uncharacterized protein. (164 aa)
	ENSPANP00000027158	Uncharacterized protein. (496 aa)
	MRTFA	Myocardin related transcription factor A. (970 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
	ENSPANP00000029657	PKS_ER domain-containing protein. (372 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	HDC	Histidine decarboxylase. (662 aa)
	ENSPANP00000033279	Uncharacterized protein. (126 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (416 aa)
	GSTZ1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (217 aa)
	GADL1	Glutamate decarboxylase like 1. (521 aa)
	C9orf40	Chromosome 9 open reading frame 40. (193 aa)
	ENSPANP00000040021	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (254 aa)
	ENSPANP00000040971	ADH_N domain-containing protein. (317 aa)
	HNMT	Histamine N-methyltransferase. (252 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADACL3	AADAT	ENSPANP00000010897	ENSPANP00000003337	Arylacetamide deacetylase like 3.	Aminoadipate aminotransferase.	0.403
AADACL3	KMO	ENSPANP00000010897	ENSPANP00000003534	Arylacetamide deacetylase like 3.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.552
AADACL3	KYNU	ENSPANP00000010897	ENSPANP00000016038	Arylacetamide deacetylase like 3.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.729
AADACL3	TDO2	ENSPANP00000010897	ENSPANP00000015362	Arylacetamide deacetylase like 3.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.717
AADACL4	AADAT	ENSPANP00000001394	ENSPANP00000003337	Arylacetamide deacetylase like 4.	Aminoadipate aminotransferase.	0.403
AADACL4	KMO	ENSPANP00000001394	ENSPANP00000003534	Arylacetamide deacetylase like 4.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.552
AADACL4	KYNU	ENSPANP00000001394	ENSPANP00000016038	Arylacetamide deacetylase like 4.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.729
AADACL4	TDO2	ENSPANP00000001394	ENSPANP00000015362	Arylacetamide deacetylase like 4.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.717
AADAT	AADACL3	ENSPANP00000003337	ENSPANP00000010897	Aminoadipate aminotransferase.	Arylacetamide deacetylase like 3.	0.403
AADAT	AADACL4	ENSPANP00000003337	ENSPANP00000001394	Aminoadipate aminotransferase.	Arylacetamide deacetylase like 4.	0.403
AADAT	AFMID	ENSPANP00000003337	ENSPANP00000016239	Aminoadipate aminotransferase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.931
AADAT	ALDH8A1	ENSPANP00000003337	ENSPANP00000004551	Aminoadipate aminotransferase.	Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family.	0.446
AADAT	CNDP2	ENSPANP00000003337	ENSPANP00000005979	Aminoadipate aminotransferase.	Carnosine dipeptidase 2.	0.475
AADAT	CSAD	ENSPANP00000003337	ENSPANP00000009773	Aminoadipate aminotransferase.	Cysteine sulfinic acid decarboxylase.	0.407
AADAT	DDC	ENSPANP00000003337	ENSPANP00000003355	Aminoadipate aminotransferase.	Dopa decarboxylase.	0.649
AADAT	GAD1	ENSPANP00000003337	ENSPANP00000018492	Aminoadipate aminotransferase.	Glutamate decarboxylase 1.	0.407
AADAT	GAD2	ENSPANP00000003337	ENSPANP00000023518	Aminoadipate aminotransferase.	Glutamate decarboxylase 2.	0.407
AADAT	GADL1	ENSPANP00000003337	ENSPANP00000039182	Aminoadipate aminotransferase.	Glutamate decarboxylase like 1.	0.407
AADAT	HAAO	ENSPANP00000003337	ENSPANP00000007318	Aminoadipate aminotransferase.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.517
AADAT	HDC	ENSPANP00000003337	ENSPANP00000033116	Aminoadipate aminotransferase.	Histidine decarboxylase.	0.649

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