(72 nodes) Apoptosis - multiple species, and Death-like domain superfamily network (Papio anubis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLRP10	NLR family pyrin domain containing 10. (642 aa)
	CASP4	Caspase 4; Belongs to the peptidase C14A family. (377 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	ENSPANP00000001452	Uncharacterized protein. (1038 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	BCL2	BCL2 apoptosis regulator. (238 aa)
	PYDC2	Pyrin domain containing 2. (139 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	NLRP14	NLR family pyrin domain containing 14. (1092 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (416 aa)
	NLRP7	NLR family pyrin domain containing 7. (989 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (306 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	BBC3	BCL2 binding component 3. (261 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (281 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (538 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (282 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (462 aa)
	CASP12	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (418 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	NLRP12	Uncharacterized protein. (1063 aa)
	DIABLO	Uncharacterized protein. (239 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	LOC101025906	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC103876580	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1372 aa)
	CARD18	Caspase recruitment domain family member 18. (92 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (519 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	PYDC1	Pyrin domain containing 1. (92 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1117 aa)
	AHNAK2	AHNAK nucleoprotein 2. (4762 aa)
	BIK	BCL2 interacting killer. (160 aa)
	BCL2L10	BCL2 like 10. (231 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (298 aa)
	BMF	Bcl2 modifying factor. (206 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	BID	BH3 interacting domain death agonist. (244 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	NLRP1	NLR family pyrin domain containing 1. (1479 aa)
	FAS	Fas cell surface death receptor. (342 aa)
	ENSPANP00000022457	Uncharacterized protein. (208 aa)
	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (363 aa)
	CASP5	Caspase 5; Belongs to the peptidase C14A family. (446 aa)
	LOC101008579	Cytochrome c. (105 aa)
	BOK	BCL2 family apoptosis regulator BOK. (212 aa)
	ANKK1	Ankyrin repeat and kinase domain containing 1. (721 aa)
	RNASE4	Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (126 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	NLRP6	NLR family pyrin domain containing 6. (1045 aa)
	SLA	Src like adaptor. (293 aa)
	BAX	BCL2 associated X, apoptosis regulator. (203 aa)
	CARD16	Caspase recruitment domain family member 16. (196 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	LOC100997529	Cytochrome c. (105 aa)
	GSDMD	Gasdermin D. (532 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	LOC101014039	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	NLRP2	Uncharacterized protein. (1061 aa)
	ENSPANP00000045653	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (195 aa)
	ENSPANP00000046563	Uncharacterized protein. (150 aa)
	LOC101021327	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	LOC101009375	Uncharacterized protein; Belongs to the peptidase C14A family. (352 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKK1	FADD	ENSPANP00000028679	ENSPANP00000009872	Ankyrin repeat and kinase domain containing 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.550
APAF1	BAK1	ENSPANP00000042489	ENSPANP00000039349	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.725
APAF1	BAX	ENSPANP00000042489	ENSPANP00000036654	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.755
APAF1	BCL2	ENSPANP00000042489	ENSPANP00000001764	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.832
APAF1	BCL2A1	ENSPANP00000042489	ENSPANP00000014335	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 related protein A1.	0.725
APAF1	BCL2L1	ENSPANP00000042489	ENSPANP00000016880	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.824
APAF1	BCL2L10	ENSPANP00000042489	ENSPANP00000014053	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 10.	0.725
APAF1	BCL2L11	ENSPANP00000042489	ENSPANP00000018085	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.506
APAF1	BIRC2	ENSPANP00000042489	ENSPANP00000001117	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.723
APAF1	BIRC7	ENSPANP00000042489	ENSPANP00000014436	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.705
APAF1	BOK	ENSPANP00000042489	ENSPANP00000028534	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.725
APAF1	CARD16	ENSPANP00000042489	ENSPANP00000039096	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 16.	0.868
APAF1	CARD18	ENSPANP00000042489	ENSPANP00000009114	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 18.	0.868
APAF1	CASP1	ENSPANP00000042489	ENSPANP00000006078	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 1; Belongs to the peptidase C14A family.	0.891
APAF1	CASP10	ENSPANP00000042489	ENSPANP00000009255	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.902
APAF1	CASP12	ENSPANP00000042489	ENSPANP00000006162	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.	0.883
APAF1	CASP2	ENSPANP00000042489	ENSPANP00000003247	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.921
APAF1	CASP4	ENSPANP00000042489	ENSPANP00000000646	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 4; Belongs to the peptidase C14A family.	0.868
APAF1	CASP5	ENSPANP00000042489	ENSPANP00000024592	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 5; Belongs to the peptidase C14A family.	0.868
APAF1	CASP8	ENSPANP00000042489	ENSPANP00000004676	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.939

page 1 of 63

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About