STRINGSTRING
TGFBR2 TGFBR2 SMAD7 SMAD7 TGFB2 TGFB2 USP15 USP15 TGFB1 TGFB1 RASL11B RASL11B LOC101011357 LOC101011357 TGFBR1 TGFBR1 SMAD6 SMAD6 SMAD2 SMAD2 ENG ENG FERMT2 FERMT2 BAMBI BAMBI TGFBR3L TGFBR3L TGFB3 TGFB3 SMAD3 SMAD3 TGFBR3 TGFBR3 AMH AMH INHBC INHBC LRG1 LRG1 TGFBRAP1 TGFBRAP1 LOC101011710 LOC101011710
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RASL11BRAS like family 11 member B. (248 aa)
LOC101011357Left-right determination factor. (366 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD6Mothers against decapentaplegic homolog. (481 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
ENGZP domain-containing protein. (274 aa)
FERMT2Fermitin family member 2. (681 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (310 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
AMHAnti-Mullerian hormone. (560 aa)
INHBCInhibin subunit beta C. (352 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (383 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (943 aa)
LOC101011710Left-right determination factor. (366 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.