STRINGSTRING
SMAD5 SMAD5 NLK NLK FLCN FLCN TGFBR3L TGFBR3L COL1A2 COL1A2 FUT8 FUT8 ID1 ID1 GDF5 GDF5 TGFB3 TGFB3 FOS FOS HIPK2 HIPK2 SMAD1 SMAD1 SKIL SKIL SKI SKI FMOD FMOD MSTN MSTN PML PML SMAD3 SMAD3 GLG1 GLG1 GCNT2 GCNT2 DUSP22 DUSP22 FURIN FURIN CDH5 CDH5 TGFBR3 TGFBR3 APPL2 APPL2 NRROS NRROS EID2 EID2 LTBP4 LTBP4 HPGD HPGD TGFBRAP1 TGFBRAP1 SMAD4 SMAD4 COL3A1 COL3A1 LRRC32 LRRC32 TGFBR2 TGFBR2 LOC101003314 LOC101003314 SMAD7 SMAD7 ITGB5 ITGB5 TGFB2 TGFB2 FOXH1 FOXH1 LTBP2 LTBP2 USP15 USP15 TGFB1 TGFB1 ADAM9 ADAM9 PARP1 PARP1 CHST11 CHST11 ZYX ZYX FNTA FNTA LTBP3 LTBP3 ITGA8 ITGA8 BAMBI BAMBI GDF10 GDF10 MTMR4 MTMR4 NODAL NODAL SIRT1 SIRT1 ACVR1 ACVR1 AMHR2 AMHR2 ONECUT2 ONECUT2 ENSPANP00000024775 ENSPANP00000024775 CLDN5 CLDN5 LPXN LPXN PTPRK PTPRK WFIKKN2 WFIKKN2 FERMT2 FERMT2 SRC SRC SMAD9 SMAD9 TWSG1 TWSG1 TP53 TP53 APPL1 APPL1 CITED1 CITED1 ZMIZ1 ZMIZ1 ENG ENG SMAD2 SMAD2 ACVRL1 ACVRL1 STAT3 STAT3 USP9X USP9X PXN PXN BMPR1A BMPR1A PTK2 PTK2 ITGB8 ITGB8 JUND JUND SMAD6 SMAD6 TGFBR1 TGFBR1 ITGB6 ITGB6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD5Mothers against decapentaplegic homolog. (465 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
FLCNFolliculin. (680 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (310 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (163 aa)
GDF5Growth differentiation factor 5 (Predicted). (499 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HIPK2Homeodomain interacting protein kinase 2. (1158 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
SKILSKI like proto-oncogene. (684 aa)
SKISKI proto-oncogene. (700 aa)
FMODFibromodulin. (444 aa)
MSTNMyostatin. (375 aa)
PMLPromyelocytic leukemia. (882 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GLG1Golgi glycoprotein 1. (1057 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
EID2EP300 interacting inhibitor of differentiation 2. (236 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1617 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (943 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101003314Uncharacterized protein. (889 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FOXH1Forkhead box H1. (366 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ZYXZyxin. (572 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (379 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1301 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
NODALNodal growth differentiation factor. (330 aa)
SIRT1Sirtuin 1. (743 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
ONECUT2One cut domain family member. (504 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (277 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1471 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
FERMT2Fermitin family member 2. (681 aa)
SRCTyrosine-protein kinase. (644 aa)
SMAD9Mothers against decapentaplegic homolog. (512 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (237 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
ENGZP domain-containing protein. (274 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2507 aa)
PXNPaxillin. (1082 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (824 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (309 aa)
SMAD6Mothers against decapentaplegic homolog. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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