STRINGSTRING
TP63 TP63 POU4F1 POU4F1 HAND1 HAND1 TBX1 TBX1 NOG NOG DLL3 DLL3 SFRP2 SFRP2 SETD2 SETD2 TAF10 TAF10 ITGA2 ITGA2 EPHA2 EPHA2 GDF11 GDF11 TBX3 TBX3 FOXC2 FOXC2 OSR1 OSR1 FOXH1 FOXH1 EXT2 EXT2 TIE1 TIE1 FOXF1 FOXF1 WNT5A WNT5A BMPR2 BMPR2 MSGN1 MSGN1 TBX20 TBX20 SMAD4 SMAD4 TXNRD1 TXNRD1 WNT11 WNT11 PPP2CA PPP2CA BMX BMX TLX2 TLX2 GDF3 GDF3 TBX19 TBX19 EYA1 EYA1 ETV2 ETV2 OVOL1 OVOL1 AMH AMH HOXA11 HOXA11 EOMES EOMES MEST MEST SCX SCX EPB41L5 EPB41L5 PALB2 PALB2 TBX6 TBX6 ARMC5 ARMC5 POFUT2 POFUT2 SRF SRF IRX3 IRX3 ETS2 ETS2 NF2 NF2 AXIN1 AXIN1 FOXC1 FOXC1 SMAD3 SMAD3 MESP1 MESP1 MESP2 MESP2 BMP7 BMP7 SNAI1 SNAI1 WNT3A WNT3A TBXT TBXT EXT1 EXT1 SMAD1 SMAD1 INHBA INHBA EYA2 EYA2 SSBP3 SSBP3 POGLUT1 POGLUT1 ACVR2A ACVR2A SECTM1 SECTM1 SMO SMO BMP4 BMP4 ZFP36L1 ZFP36L1 SHH SHH IKZF1 IKZF1 SIX2 SIX2 NUP133 NUP133 LHX2 LHX2 CRB2 CRB2 CTDNEP1 CTDNEP1 KDM6B KDM6B HES7 HES7 ITGA8 ITGA8 NODAL NODAL IKZF3 IKZF3 WNT3 WNT3 PAX2 PAX2 FGF8 FGF8 RPL38 RPL38 ACVR1 ACVR1 FGFR2 FGFR2 ENSPANP00000024775 ENSPANP00000024775 ACVR2B ACVR2B EXOC4 EXOC4 TCF15 TCF15 LDB1 LDB1 ENSPANP00000031315 ENSPANP00000031315 TWSG1 TWSG1 LEF1 LEF1 ITGB3 ITGB3 ITGA3 ITGA3 YAP1 YAP1 SMAD2 SMAD2 DAND5 DAND5 HNF1A HNF1A HMGA2 HMGA2 KLF4 KLF4 ENSPANP00000041545 ENSPANP00000041545 BMPR1A BMPR1A APELA APELA DKK1 DKK1 ENSPANP00000043407 ENSPANP00000043407 ITGB4 ITGB4 ZFPM2 ZFPM2 ZIC3 ZIC3 BTK BTK TEAD2 TEAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
POU4F1POU domain protein. (414 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TBX1T-box transcription factor 1. (491 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2544 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1161 aa)
EPHA2EPH receptor A2. (976 aa)
GDF11Growth differentiation factor 11. (406 aa)
TBX3T-box transcription factor 3. (743 aa)
FOXC2Forkhead box C2. (494 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FOXH1Forkhead box H1. (366 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
FOXF1Forkhead box F1. (432 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MSGN1Mesogenin 1. (193 aa)
TBX20T-box transcription factor 20. (447 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TXNRD1Thioredoxin reductase 1. (648 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BMXTyrosine-protein kinase. (679 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
GDF3Growth differentiation factor 3. (335 aa)
TBX19T-box transcription factor 19. (448 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
ETV2ETS variant 2. (370 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
AMHAnti-Mullerian hormone. (560 aa)
HOXA11Homeobox A11 (Predicted). (311 aa)
EOMESEomesodermin. (705 aa)
MESTMesoderm specific transcript. (335 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (688 aa)
PALB2Partner and localizer of BRCA2. (1184 aa)
TBX6T-box transcription factor 6. (436 aa)
ARMC5Armadillo repeat containing 5. (1029 aa)
POFUT2Protein O-fucosyltransferase 2. (429 aa)
SRFSerum response factor. (508 aa)
IRX3Iroquois homeobox 3. (500 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
NF2Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (595 aa)
AXIN1Axin 1, isoform 1 (Predicted). (867 aa)
FOXC1Fork-head domain-containing protein. (210 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (373 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TBXTT-box transcription factor T. (435 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
INHBAInhibin subunit beta A. (426 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
SSBP3Single stranded DNA binding protein 3. (388 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SECTM1Secreted and transmembrane 1. (243 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
IKZF1IKAROS family zinc finger 1. (519 aa)
SIX2SIX homeobox 2. (290 aa)
NUP133Nucleoporin 133. (1156 aa)
LHX2LIM homeobox 2. (406 aa)
CRB2Crumbs cell polarity complex component 2. (1290 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
KDM6BLysine demethylase 6B. (1677 aa)
HES7Hes family bHLH transcription factor 7. (230 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
NODALNodal growth differentiation factor. (330 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PAX2Paired box 2. (436 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
EXOC4Exocyst complex component 4. (974 aa)
TCF15Transcription factor 15. (198 aa)
LDB1LIM domain binding 1. (411 aa)
ENSPANP00000031315Homeobox domain-containing protein. (140 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (237 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
YAP1Yes associated protein 1. (506 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
HNF1AHNF1 homeobox A. (662 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
KLF4Kruppel like factor 4. (511 aa)
ENSPANP00000041545FCP1 homology domain-containing protein. (110 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
APELAApelin receptor early endogenous ligand. (55 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ENSPANP00000043407Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (190 aa)
ITGB4Integrin beta. (1752 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
ZIC3Zic family member 3. (466 aa)
BTKTyrosine-protein kinase. (659 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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