STRINGSTRING
CTNNB1 CTNNB1 PDPN PDPN TGFBR1 TGFBR1 LOXL2 LOXL2 ENSPANP00000040479 ENSPANP00000040479 BMP2 BMP2 TIAM1 TIAM1 SMAD2 SMAD2 ENG ENG ENSPANP00000036680 ENSPANP00000036680 LEF1 LEF1 GLIPR2 GLIPR2 FERMT2 FERMT2 TCF7L2 TCF7L2 ISL1 ISL1 OLFM1 OLFM1 ACVR1 ACVR1 IL6 IL6 COL1A1 COL1A1 BAMBI BAMBI CRB2 CRB2 JAG1 JAG1 BMP4 BMP4 AXIN2 AXIN2 TGFB3 TGFB3 MTOR MTOR NOTCH1 NOTCH1 HDAC2 HDAC2 SNAI1 SNAI1 BMP7 BMP7 SMAD3 SMAD3 EMP2 EMP2 GCNT2 GCNT2 FOXC1 FOXC1 TGFB1I1 TGFB1I1 IL1B IL1B DAB2 DAB2 LRG1 LRG1 SMAD4 SMAD4 TBX20 TBX20 TGFBR2 TGFBR2 EZH2 EZH2 BCL9L BCL9L ZNF703 ZNF703 TGFB2 TGFB2 ALX1 ALX1 SDCBP SDCBP TGFB1 TGFB1 RGCC RGCC ENSPANP00000001806 ENSPANP00000001806 MDK MDK WWTR1 WWTR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
PDPNPodoplanin. (206 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
ENSPANP00000040479PDZ domain-containing protein. (263 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1577 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
ENGZP domain-containing protein. (274 aa)
ENSPANP00000036680PDZ domain-containing protein. (290 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
FERMT2Fermitin family member 2. (681 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
ISL1ISL LIM homeobox 1. (395 aa)
OLFM1Olfactomedin 1. (485 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
IL6Uncharacterized protein. (214 aa)
COL1A1Collagen type I alpha 1 chain. (1369 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
CRB2Crumbs cell polarity complex component 2. (1290 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1190 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
AXIN2Axin 2. (844 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NOTCH1Notch receptor 1. (2541 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (503 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
FOXC1Fork-head domain-containing protein. (210 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
DAB2DAB adaptor protein 2. (770 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (383 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TBX20T-box transcription factor 20. (447 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
BCL9LBCL9 like. (1500 aa)
ZNF703Zinc finger protein 703. (591 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ALX1ALX homeobox 1. (326 aa)
SDCBPSyndecan binding protein. (318 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RGCCRegulator of cell cycle. (161 aa)
ENSPANP00000001806PDZ domain-containing protein. (258 aa)
MDKMidkine. (161 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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