STRINGSTRING
NF1 NF1 CSF1R CSF1R MECP2 MECP2 IL34 IL34 AREG AREG SHANK3 SHANK3 GFAP GFAP PTK2B PTK2B LEPR LEPR ORC3 ORC3 LGI4 LGI4 CLU CLU EPM2A EPM2A PENK PENK VEGFC VEGFC KRAS KRAS TREM2 TREM2 CX3CL1 CX3CL1 NF2 NF2 SOX4 SOX4 RB1 RB1 CSF1 CSF1 IL33 IL33 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin 1. (2839 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
IL34Interleukin 34. (242 aa)
AREGAmphiregulin. (274 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1709 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (517 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
LEPRLeptin receptor. (1163 aa)
ORC3Origin recognition complex subunit 3. (690 aa)
LGI4Leucine rich repeat LGI family member 4. (524 aa)
CLUClusterin; Belongs to the clusterin family. (501 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
PENKProenkephalin. (267 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
NF2Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (595 aa)
SOX4Transcription factor SOX. (448 aa)
RB1RB transcriptional corepressor 1. (889 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
IL33Interleukin 33. (270 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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