STRINGSTRING
RNF20 RNF20 PCGF3 PCGF3 PHC1 PHC1 RNF168 RNF168 DDB2 DDB2 LEO1 LEO1 UBR2 UBR2 RNF40 RNF40 RNF8 RNF8 PCGF1 PCGF1 ENSPANP00000011106 ENSPANP00000011106 UHRF1 UHRF1 RAG1 RAG1 UBE2N UBE2N UBE2B UBE2B RING1 RING1 TRIM37 TRIM37 LOC103880518 LOC103880518 DDB1 DDB1 BRCA2 BRCA2 CBX8 CBX8 UBE2A UBE2A SKP1 SKP1 CUL4B CUL4B CDC73 CDC73 BCOR BCOR UBE2E1 UBE2E1 LOC101026281 LOC101026281 RAD51 RAD51 HUWE1 HUWE1 CTR9 CTR9 DTX3L DTX3L LOC101001699 LOC101001699 RYBP RYBP KDM2B KDM2B RNF2 RNF2 BARD1 BARD1 WAC WAC BMI1 BMI1 PCGF6 PCGF6 ATXN7L3 ATXN7L3 PCGF5 PCGF5 PCGF2 PCGF2 SUZ12 SUZ12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
PHC1Polyhomeotic homolog 1. (1003 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
ENSPANP00000011106UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (859 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
RING1Ring finger protein 1. (412 aa)
TRIM37Tripartite motif containing 37. (963 aa)
LOC103880518UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
BRCA2BRCA2 DNA repair associated. (3430 aa)
CBX8Chromobox 8. (418 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (165 aa)
CUL4BCullin 4B; Belongs to the cullin family. (931 aa)
CDC73Cell division cycle 73. (531 aa)
BCORBCL6 corepressor. (1752 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
LOC101026281RING-type domain-containing protein. (319 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4390 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
LOC101001699S-phase kinase-associated protein 1. (163 aa)
RYBPRING1 and YY1 binding protein. (228 aa)
KDM2BLysine demethylase 2B. (1338 aa)
RNF2Ring finger protein 2. (336 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
WACWW domain containing adaptor with coiled-coil. (653 aa)
BMI1RING-type domain-containing protein. (326 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (400 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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