STRINGSTRING
NRP1 NRP1 HOXB13 HOXB13 PTCH1 PTCH1 TNC TNC ARG1 ARG1 CSF1 CSF1 CUL3 CUL3 BSX BSX TGM2 TGM2 SHH SHH BMP4 BMP4 FOXA1 FOXA1 CAV1 CAV1 SOX9 SOX9 MKI67 MKI67 TGFB3 TGFB3 NOTCH1 NOTCH1 MST1 MST1 GDF7 GDF7 ESR1 ESR1 HOXD13 HOXD13 CEBPB CEBPB BMP7 BMP7 LAMA5 LAMA5 PML PML FEM1B FEM1B FGF7 FGF7 DUOX2 DUOX2 ID4 ID4 CRIP1 CRIP1 LRRC1 LRRC1 MMP2 MMP2 PLAG1 PLAG1 NFKB1 NFKB1 CSF1R CSF1R NKX3-1 NKX3-1 LOC101022119 LOC101022119 FRS2 FRS2 ELF3 ELF3 VDR VDR AR AR TGFBR2 TGFBR2 SERPINB5 SERPINB5 SEMA3C SEMA3C WNT5A WNT5A LAMA1 LAMA1 TGFB2 TGFB2 IGFBP5 IGFBP5 CSMD2 CSMD2 NOTCH2 NOTCH2 TGFB1 TGFB1 TBX3 TBX3 BCL2 BCL2 NOG NOG SFRP1 SFRP1 SCRIB SCRIB DAG1 DAG1 STAT6 STAT6 WNT4 WNT4 EPHA2 EPHA2 PLXND1 PLXND1 FGF10 FGF10 FGL1 FGL1 PROX1 PROX1 ESRP2 ESRP2 POLB POLB NRG3 NRG3 EDA EDA ENSPANP00000046151 ENSPANP00000046151 PLXNA1 PLXNA1 AREG AREG RARG RARG SELENOH SELENOH PAX6 PAX6 GLI3 GLI3 NKX2-3 NKX2-3 SOSTDC1 SOSTDC1 TP63 TP63 TGFA TGFA DDR1 DDR1 EDAR EDAR TWSG1 TWSG1 CSMD1 CSMD1 RPS6KA1 RPS6KA1 NFIB NFIB LRP5 LRP5 SRC SRC KDM5B KDM5B MSN MSN BTRC BTRC FGFR2 FGFR2 IL6 IL6 HOXA13 HOXA13 FGF8 FGF8 MED1 MED1 TBX2 TBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
HOXB13Homeobox B13. (288 aa)
PTCH1Patched 1. (1452 aa)
TNCTenascin C. (2201 aa)
ARG1Arginase. (322 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
BSXBrain specific homeobox. (204 aa)
TGM2Transglutaminase 2. (687 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
FOXA1Forkhead box A1. (470 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
SOX9SRY-box transcription factor 9. (509 aa)
MKI67Marker of proliferation Ki-67. (3249 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NOTCH1Notch receptor 1. (2541 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
GDF7Growth differentiation factor 7. (447 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
HOXD13Homeobox D13. (343 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
PMLPromyelocytic leukemia. (882 aa)
FEM1BFem-1 homolog B. (627 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DUOX2Dual oxidase 2. (1516 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
CRIP1LIM zinc-binding domain-containing protein. (77 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PLAG1PLAG1 zinc finger. (500 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
NKX3-1NK3 homeobox 1. (232 aa)
LOC101022119Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
VDRVitamin D receptor. (544 aa)
ARAndrogen receptor. (896 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LAMA1Laminin subunit alpha 1. (3024 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
CSMD2CUB and Sushi multiple domains 2. (3613 aa)
NOTCH2Notch receptor 2. (2603 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TBX3T-box transcription factor 3. (743 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SCRIBScribble planar cell polarity protein. (1661 aa)
DAG1Dystroglycan 1. (893 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EPHA2EPH receptor A2. (976 aa)
PLXND1Plexin D1. (1924 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGL1Fibrinogen like 1. (312 aa)
PROX1Prospero homeobox 1. (737 aa)
ESRP2Epithelial splicing regulatory protein 2. (725 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (370 aa)
NRG3Neuregulin 3. (719 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
ENSPANP00000046151Uncharacterized protein. (65 aa)
PLXNA1Plexin A1. (2042 aa)
AREGAmphiregulin. (274 aa)
RARGRetinoic acid receptor gamma. (463 aa)
SELENOHSelenoprotein H. (121 aa)
PAX6Paired box 6. (462 aa)
GLI3GLI family zinc finger 3. (1580 aa)
NKX2-3NK2 homeobox 3. (365 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
TGFATransforming growth factor alpha. (166 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (920 aa)
EDAREctodysplasin A receptor. (515 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (237 aa)
CSMD1CUB and Sushi multiple domains 1. (3500 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
SRCTyrosine-protein kinase. (644 aa)
KDM5BLysine demethylase 5B. (1580 aa)
MSNMoesin. (581 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
IL6Uncharacterized protein. (214 aa)
HOXA13Homeobox A13. (367 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1548 aa)
TBX2T-box transcription factor 2. (704 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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