STRINGSTRING
BMPER BMPER SMAD5 SMAD5 BMP8B BMP8B LOC101011357 LOC101011357 SLC39A5 SLC39A5 NOG NOG SFRP1 SFRP1 SFRP2 SFRP2 DSG4 DSG4 FST FST DLX5 DLX5 GDF6 GDF6 TGFB1 TGFB1 USP15 USP15 NOTCH2 NOTCH2 TGFB2 TGFB2 BMP15 BMP15 SMAD7 SMAD7 WNT5A WNT5A BMPR2 BMPR2 RGMB RGMB CCDC142 CCDC142 HJV HJV ZNF8 ZNF8 CHRD CHRD SMAD4 SMAD4 LOC101011710 LOC101011710 SPART SPART BMP10 BMP10 GDF3 GDF3 ETV2 ETV2 CHRDL1 CHRDL1 SCX SCX TGFBR3 TGFBR3 SLC33A1 SLC33A1 MAPK3 MAPK3 TMPRSS6 TMPRSS6 BMP6 BMP6 HIVEP1 HIVEP1 HFE HFE SMAD3 SMAD3 RGMA RGMA BMP7 BMP7 SMPD3 SMPD3 GDF7 GDF7 EXT1 EXT1 SMAD1 SMAD1 TGFB3 TGFB3 ACVR2A ACVR2A GDF5 GDF5 BMP4 BMP4 ENSPANP00000018389 ENSPANP00000018389 ATF2 ATF2 MSX1 MSX1 SMURF1 SMURF1 FAM83G FAM83G DLX3 DLX3 TMEM100 TMEM100 NODAL NODAL SOST SOST BMPR1B BMPR1B EGR1 EGR1 RUNX2 RUNX2 GDF2 GDF2 ACVR1 ACVR1 FKBP8 FKBP8 ZNF831 ZNF831 ENSPANP00000024775 ENSPANP00000024775 ACVR2B ACVR2B MEGF8 MEGF8 DDX5 DDX5 HES5 HES5 SMAD9 SMAD9 TWSG1 TWSG1 ZCCHC12 ZCCHC12 ABL1 ABL1 LEF1 LEF1 ENSPANP00000036120 ENSPANP00000036120 BMP5 BMP5 PDCD4 PDCD4 ENG ENG COMP COMP ACVRL1 ACVRL1 SOSTDC1 SOSTDC1 USP9X USP9X BMP2 BMP2 BMPR1A BMPR1A ZCCHC18 ZCCHC18 SMAD6 SMAD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPERBMP binding endothelial regulator. (686 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
LOC101011357Left-right determination factor. (366 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1055 aa)
FSTFollistatin. (344 aa)
DLX5Distal-less homeobox 5. (289 aa)
GDF6Growth differentiation factor 6. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
NOTCH2Notch receptor 2. (2603 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (539 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
HJVHemojuvelin BMP co-receptor. (426 aa)
ZNF8Zinc finger protein 8. (575 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC101011710Left-right determination factor. (366 aa)
SPARTSpartin. (666 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GDF3Growth differentiation factor 3. (335 aa)
ETV2ETS variant 2. (370 aa)
CHRDL1Chordin like 1. (458 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (809 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2718 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
GDF7Growth differentiation factor 7. (447 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF5Growth differentiation factor 5 (Predicted). (499 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
ENSPANP00000018389TGF_BETA_2 domain-containing protein. (391 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MSX1Msh homeobox 1. (284 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
FAM83GFamily with sequence similarity 83 member G. (823 aa)
DLX3Distal-less homeobox 3. (280 aa)
TMEM100Transmembrane protein 100. (134 aa)
NODALNodal growth differentiation factor. (330 aa)
SOSTSclerostin. (258 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
RUNX2RUNX family transcription factor 2. (611 aa)
GDF2Growth differentiation factor 2. (429 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
FKBP8Peptidylprolyl isomerase. (421 aa)
ZNF831Zinc finger protein 831. (1670 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
MEGF8Multiple EGF like domains 8. (2825 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
SMAD9Mothers against decapentaplegic homolog. (512 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (237 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
ABL1Tyrosine-protein kinase. (1112 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ENSPANP00000036120TPR_REGION domain-containing protein. (132 aa)
BMP5Bone morphogenetic protein 5. (471 aa)
PDCD4Programmed cell death 4. (470 aa)
ENGZP domain-containing protein. (274 aa)
COMPCartilage oligomeric matrix protein. (841 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2507 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZCCHC18Zinc finger CCHC-type containing 18. (375 aa)
SMAD6Mothers against decapentaplegic homolog. (481 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.