(64 nodes) Phagocytic vesicle membrane network (Papio anubis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	TLR1	Toll-like receptor. (786 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (901 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	SYT7	Synaptotagmin 7. (686 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	RAB31	RAB31, member RAS oncogene family. (194 aa)
	CLEC4E	C-type lectin domain family 4 member E. (219 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	RAB20	RAB20, member RAS oncogene family. (234 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa)
	RAB43	RAB43, member RAS oncogene family. (212 aa)
	SLC11A1	Solute carrier family 11 member 1. (547 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1282 aa)
	ANXA3	Annexin. (323 aa)
	RAB39A	RAB39A, member RAS oncogene family. (217 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
	TLR2	Toll-like receptor. (784 aa)
	RAB32	Uncharacterized protein. (225 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	HVCN1	Hydrogen voltage gated channel 1. (273 aa)
	ATP7A	ATPase copper transporting alpha. (1487 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
	TAPBP	TAP binding protein. (503 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	ENSPANP00000013908	Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (324 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
	LOC101015220	MHC class I protein; Belongs to the MHC class I family. (365 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (957 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	RILP	Rab interacting lysosomal protein. (389 aa)
	LOC101019755	Ig-like domain-containing protein; Belongs to the MHC class I family. (382 aa)
	LOC101021633	Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
	ENSPANP00000027932	MHC_I-like_Ag-recog domain-containing protein. (213 aa)
	LAMP1	Lysosomal associated membrane protein 1. (416 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (836 aa)
	ENSPANP00000029353	MHC_I-like_Ag-recog domain-containing protein. (152 aa)
	LAMP2	Lysosomal associated membrane protein 2. (411 aa)
	MCOLN1	Mucolipin 1. (601 aa)
	ENSPANP00000033549	Uncharacterized protein. (210 aa)
	LOC101002482	Ig-like domain-containing protein; Belongs to the MHC class I family. (404 aa)
	VAMP8	Vesicle associated membrane protein 8. (100 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (487 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	IRGM	Immunity related GTPase M. (159 aa)
	ENSPANP00000039524	IGc1 domain-containing protein; Belongs to the MHC class I family. (339 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (897 aa)
	ENSPANP00000042342	Ig-like domain-containing protein; Belongs to the MHC class I family. (397 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (236 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	ENSPANP00000044663	Ig-like domain-containing protein; Belongs to the MHC class I family. (348 aa)
	RAB34	RAB34, member RAS oncogene family. (267 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL2	ENSPANP00000033549	ENSPANP00000010536	ENSPANP00000033549	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.870
APPL2	RAB20	ENSPANP00000010536	ENSPANP00000004433	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB20, member RAS oncogene family.	0.870
APPL2	RAB22A	ENSPANP00000010536	ENSPANP00000014537	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB22A, member RAS oncogene family.	0.870
APPL2	RAB31	ENSPANP00000010536	ENSPANP00000002619	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB31, member RAS oncogene family.	0.870
APPL2	RAB5A	ENSPANP00000010536	ENSPANP00000001530	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB5A, member RAS oncogene family.	0.870
ATP6V0A2	ATP6V0A4	ENSPANP00000008366	ENSPANP00000029105	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.941
ATP6V0A2	ATP6V0B	ENSPANP00000008366	ENSPANP00000004440	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.995
ATP6V0A2	ATP6V0C	ENSPANP00000008366	ENSPANP00000013721	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6V0A2	TCIRG1	ENSPANP00000008366	ENSPANP00000007900	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.939
ATP6V0A4	ATP6V0A2	ENSPANP00000029105	ENSPANP00000008366	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.941
ATP6V0A4	ATP6V0B	ENSPANP00000029105	ENSPANP00000004440	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.992
ATP6V0A4	ATP6V0C	ENSPANP00000029105	ENSPANP00000013721	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.996
ATP6V0A4	TCIRG1	ENSPANP00000029105	ENSPANP00000007900	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.942
ATP6V0B	ATP6V0A2	ENSPANP00000004440	ENSPANP00000008366	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.995
ATP6V0B	ATP6V0A4	ENSPANP00000004440	ENSPANP00000029105	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6V0B	ATP6V0C	ENSPANP00000004440	ENSPANP00000013721	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6V0B	TCIRG1	ENSPANP00000004440	ENSPANP00000007900	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.995
ATP6V0C	ATP6V0A2	ENSPANP00000013721	ENSPANP00000008366	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
ATP6V0C	ATP6V0A4	ENSPANP00000013721	ENSPANP00000029105	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.996
ATP6V0C	ATP6V0B	ENSPANP00000013721	ENSPANP00000004440	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.999

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