(40 nodes) Response to fluid shear stress network (Papio anubis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
	ENSPANP00000047678	Uncharacterized protein. (103 aa)
	SMAD6	Mothers against decapentaplegic homolog. (481 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	ENSPANP00000043438	Uncharacterized protein. (435 aa)
	KLF4	Kruppel like factor 4. (511 aa)
	ENSPANP00000036984	Uncharacterized protein. (107 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (596 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	ENSPANP00000021415	Uncharacterized protein. (442 aa)
	ENSPANP00000020409	Uncharacterized protein. (375 aa)
	PLEC	Uncharacterized protein. (4680 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2261 aa)
	ASS1	Uncharacterized protein. (412 aa)
	TFPI2	Tissue factor pathway inhibitor. (235 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	SOCS5	Uncharacterized protein. (536 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4297 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1272 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	LOC101012072	Uncharacterized protein. (536 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (537 aa)
	LOC101003421	BZIP domain-containing protein. (371 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	KLF2	Kruppel like factor 2. (356 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	SMAD7	Mothers against decapentaplegic homolog. (493 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	MTSS1	MTSS I-BAR domain containing 1. (759 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor (Predicted). (144 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	ENSPANP00000000847	Uncharacterized protein. (439 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	SREBF2	ENSPANP00000019018	ENSPANP00000013431	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.570
AKT1	KLF4	ENSPANP00000013336	ENSPANP00000041449	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Kruppel like factor 4.	0.412
AKT1	MMP2	ENSPANP00000013336	ENSPANP00000012748	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Matrix metallopeptidase 2.	0.452
AKT1	NFE2L2	ENSPANP00000013336	ENSPANP00000036324	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 2.	0.697
AKT1	NOS3	ENSPANP00000013336	ENSPANP00000017929	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.979
AKT1	SMAD7	ENSPANP00000013336	ENSPANP00000005066	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.411
AKT1	SRC	ENSPANP00000013336	ENSPANP00000029342	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.780
AKT1	TGFB1	ENSPANP00000013336	ENSPANP00000004153	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.508
ASS1	ENSPANP00000000847	ENSPANP00000018836	ENSPANP00000000847	Uncharacterized protein.	Uncharacterized protein.	0.797
ASS1	ENSPANP00000021415	ENSPANP00000018836	ENSPANP00000021415	Uncharacterized protein.	Uncharacterized protein.	0.797
ASS1	ENSPANP00000043438	ENSPANP00000018836	ENSPANP00000043438	Uncharacterized protein.	Uncharacterized protein.	0.797
ASS1	NOS3	ENSPANP00000018836	ENSPANP00000017929	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.903
CSF2	PDGFRB	ENSPANP00000003147	ENSPANP00000007796	Granulocyte-macrophage colony-stimulating factor (Predicted).	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.783
ENSPANP00000000847	ASS1	ENSPANP00000000847	ENSPANP00000018836	Uncharacterized protein.	Uncharacterized protein.	0.797
ENSPANP00000000847	NOS3	ENSPANP00000000847	ENSPANP00000017929	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.810
ENSPANP00000020409	NOS3	ENSPANP00000020409	ENSPANP00000017929	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.426
ENSPANP00000021415	ASS1	ENSPANP00000021415	ENSPANP00000018836	Uncharacterized protein.	Uncharacterized protein.	0.797
ENSPANP00000021415	NOS3	ENSPANP00000021415	ENSPANP00000017929	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.810
ENSPANP00000036984	P2RX4	ENSPANP00000036984	ENSPANP00000032948	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.837
ENSPANP00000036984	P2RX7	ENSPANP00000036984	ENSPANP00000010339	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.550

page 1 of 5

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About