STRINGSTRING
BMPR1A BMPR1A FGF4 FGF4 FGF10 FGF10 MED12 MED12 NOG NOG SFRP1 SFRP1 NIPBL NIPBL ZHX2 ZHX2 ZFP36L2 ZFP36L2 WNT7A WNT7A BCL9L BCL9L VPS72 VPS72 KLF10 KLF10 LIG4 LIG4 GATA2 GATA2 MED14 MED14 REST REST BCL9 BCL9 SMC1A SMC1A MED30 MED30 MED21 MED21 CUL4A CUL4A LIF LIF SOX4 SOX4 SALL4 SALL4 ASCL2 ASCL2 MED7 MED7 SKI SKI MED15 MED15 SOX9 SOX9 SIX2 SIX2 RIF1 RIF1 LDB2 LDB2 MED28 MED28 KIT KIT BRAF BRAF MED27 MED27 NODAL NODAL WNT9B WNT9B CDKN2B CDKN2B LOC101003193 LOC101003193 ENSPANP00000024775 ENSPANP00000024775 LDB1 LDB1 LRP5 LRP5 NR2E1 NR2E1 YAP1 YAP1 STAT3 STAT3 KLF4 KLF4 CDX2 CDX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MED12Mediator complex subunit 12. (2178 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NIPBLNipped-B protein. (2776 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
ZFP36L2ZFP36 ring finger protein like 2. (492 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
BCL9LBCL9 like. (1500 aa)
VPS72Vacuolar protein sorting 72 homolog (Predicted). (364 aa)
KLF10Kruppel like factor 10. (480 aa)
LIG4DNA ligase. (911 aa)
GATA2GATA binding protein 2. (480 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
RESTRE1 silencing transcription factor. (1094 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
SMC1AStructural maintenance of chromosomes protein. (1198 aa)
MED30Mediator complex subunit 30. (178 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
CUL4ACullin 4A; Belongs to the cullin family. (763 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SOX4Transcription factor SOX. (448 aa)
SALL4Spalt like transcription factor 4. (951 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
SKISKI proto-oncogene. (700 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
SOX9SRY-box transcription factor 9. (509 aa)
SIX2SIX homeobox 2. (290 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
LDB2LIM domain binding 2. (407 aa)
MED28Mediator complex subunit 28. (191 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
MED27Mediator complex subunit 27. (311 aa)
NODALNodal growth differentiation factor. (330 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CDKN2BUncharacterized protein. (173 aa)
LOC101003193Uncharacterized protein. (477 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
LDB1LIM domain binding 1. (411 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
NR2E1Uncharacterized protein. (430 aa)
YAP1Yes associated protein 1. (506 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
KLF4Kruppel like factor 4. (511 aa)
CDX2Caudal type homeobox 2. (313 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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