STRINGSTRING
ARX ARX FGF10 FGF10 PRLR PRLR LEPR LEPR BCL2 BCL2 DDR2 DDR2 ECM1 ECM1 GATA6 GATA6 SORBS2 SORBS2 LEP LEP FOXC2 FOXC2 TGFB2 TGFB2 DLL1 DLL1 THBS3 THBS3 TENM4 TENM4 TGFBR2 TGFBR2 AR AR ZMPSTE24 ZMPSTE24 GATA4 GATA4 STC1 STC1 PTPN11 PTPN11 WNT2 WNT2 IL7 IL7 RAG2 RAG2 TSKU TSKU MATN1 MATN1 IER3IP1 IER3IP1 SPRY2 SPRY2 PDGFRB PDGFRB HLX HLX BMP10 BMP10 S1PR1 S1PR1 OSTN OSTN NKX2-5 NKX2-5 PLAG1 PLAG1 IFT80 IFT80 RSPO2 RSPO2 DIPK2A DIPK2A TGFBR3 TGFBR3 EHMT2 EHMT2 NDRG4 NDRG4 FOXC1 FOXC1 MAPK11 MAPK11 JARID2 JARID2 FGF7 FGF7 MESP1 MESP1 SMPD3 SMPD3 HEG1 HEG1 ESR1 ESR1 EXT1 EXT1 SMAD1 SMAD1 NOTCH1 NOTCH1 SOX9 SOX9 SAV1 SAV1 SHH SHH LOC101026774 LOC101026774 NPPC NPPC ATF2 ATF2 COL27A1 COL27A1 TMEM38B TMEM38B BNC2 BNC2 CER1 CER1 FXN FXN MAP2K4 MAP2K4 LOC101008824 LOC101008824 PTEN PTEN FGF8 FGF8 ENSPANP00000023223 ENSPANP00000023223 FGFR2 FGFR2 ANKRD26 ANKRD26 FGF9 FGF9 ENSPANP00000024616 ENSPANP00000024616 ACVR2B ACVR2B ENSPANP00000025285 ENSPANP00000025285 FGFR3 FGFR3 GJE1 GJE1 ANXA6 ANXA6 MMP13 MMP13 ENSPANP00000028630 ENSPANP00000028630 PSAP PSAP ENSPANP00000029665 ENSPANP00000029665 ENSPANP00000030298 ENSPANP00000030298 AKAP13 AKAP13 ADRA1A ADRA1A TBX5 TBX5 EVC EVC ENSPANP00000033846 ENSPANP00000033846 ENSPANP00000034620 ENSPANP00000034620 RARB RARB CYP19A1 CYP19A1 YAP1 YAP1 SMAD2 SMAD2 COMP COMP ENSPANP00000039054 ENSPANP00000039054 CCDC144A CCDC144A RARG RARG ENSPANP00000040910 ENSPANP00000040910 ENSPANP00000041355 ENSPANP00000041355 UBE3A UBE3A HEY2 HEY2 STK3 STK3 PDLIM5 PDLIM5 RARA RARA ENSPANP00000044280 ENSPANP00000044280 ARID2 ARID2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARXAristaless related homeobox. (516 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
LEPRLeptin receptor. (1163 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
ECM1Extracellular matrix protein 1. (567 aa)
GATA6GATA binding protein 6. (595 aa)
SORBS2Sorbin and SH3 domain containing 2. (1200 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
FOXC2Forkhead box C2. (494 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
THBS3Thrombospondin 3. (956 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ARAndrogen receptor. (896 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (434 aa)
GATA4GATA binding protein 4. (442 aa)
STC1Stanniocalcin 1. (247 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
RAG2Recombination activating 2. (532 aa)
TSKUTsukushi, small leucine rich proteoglycan. (367 aa)
MATN1Matrilin 1. (495 aa)
IER3IP1Immediate early response 3 interacting protein 1. (82 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HLXH2.0 like homeobox. (494 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
OSTNOsteocrin. (133 aa)
NKX2-5NK2 homeobox 5. (324 aa)
PLAG1PLAG1 zinc finger. (500 aa)
IFT80Intraflagellar transport 80. (777 aa)
RSPO2R-spondin 2. (243 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
NDRG4NDRG family member 4. (421 aa)
FOXC1Fork-head domain-containing protein. (210 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1207 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
HEG1Heart development protein with EGF like domains 1. (1379 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
NOTCH1Notch receptor 1. (2541 aa)
SOX9SRY-box transcription factor 9. (509 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
LOC101026774Uncharacterized protein. (1852 aa)
NPPCNatriuretic peptide C. (126 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1859 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
BNC2Basonuclin 2. (1099 aa)
CER1Cerberus 1, DAN family BMP antagonist. (269 aa)
FXNFrataxin. (210 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (466 aa)
LOC101008824Uncharacterized protein. (1337 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ENSPANP00000023223Uncharacterized protein. (136 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ANKRD26Ankyrin repeat domain 26. (1611 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPANP00000024616HECT domain-containing protein. (55 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ENSPANP00000025285ANK_REP_REGION domain-containing protein. (293 aa)
FGFR3Fibroblast growth factor receptor. (775 aa)
GJE1Gap junction protein epsilon 1. (185 aa)
ANXA6Annexin. (685 aa)
MMP13Matrix metallopeptidase 13. (501 aa)
ENSPANP00000028630Uncharacterized protein. (441 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (546 aa)
ENSPANP00000029665HECT domain-containing protein. (51 aa)
ENSPANP00000030298HECT domain-containing protein. (728 aa)
AKAP13A-kinase anchoring protein 13. (2875 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
TBX5T-box transcription factor 5. (518 aa)
EVCEvC ciliary complex subunit 1. (1107 aa)
ENSPANP00000033846Uncharacterized protein. (542 aa)
ENSPANP00000034620Uncharacterized protein. (69 aa)
RARBRetinoic acid receptor beta. (448 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
YAP1Yes associated protein 1. (506 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
COMPCartilage oligomeric matrix protein. (841 aa)
ENSPANP00000039054DUF3496 domain-containing protein. (145 aa)
CCDC144AUncharacterized protein. (1166 aa)
RARGRetinoic acid receptor gamma. (463 aa)
ENSPANP00000040910Uncharacterized protein. (120 aa)
ENSPANP00000041355Uncharacterized protein. (489 aa)
UBE3AUbiquitin protein ligase E3A. (788 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (326 aa)
STK3Serine/threonine kinase 3. (534 aa)
PDLIM5PDZ and LIM domain 5. (625 aa)
RARARetinoic acid receptor alpha. (478 aa)
ENSPANP00000044280Uncharacterized protein. (178 aa)
ARID2AT-rich interaction domain 2. (1817 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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