STRINGSTRING
SAV1 SAV1 AMOT AMOT DCHS1 DCHS1 LATS2 LATS2 TEAD4 TEAD4 FAT4 FAT4 PJA2 PJA2 WWTR1 WWTR1 LATS1 LATS1 STK4 STK4 MOB1A MOB1A ENSPANP00000030561 ENSPANP00000030561 YAP1 YAP1 TEAD3 TEAD3 STK3 STK3 TEAD1 TEAD1 MOB1B MOB1B TEAD2 TEAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SAV1Salvador family WW domain containing protein 1. (384 aa)
AMOTAngiomotin. (1011 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
FAT4FAT atypical cadherin 4. (4983 aa)
PJA2Praja ring finger ubiquitin ligase 2. (708 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
MOB1AUncharacterized protein. (221 aa)
ENSPANP00000030561Uncharacterized protein. (216 aa)
YAP1Yes associated protein 1. (506 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
STK3Serine/threonine kinase 3. (534 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
MOB1BMOB kinase activator 1B. (221 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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