STRINGSTRING
ATF2 ATF2 SMARCA5 SMARCA5 ENSPANP00000025644 ENSPANP00000025644 SHLD2 SHLD2 ENSPANP00000022961 ENSPANP00000022961 POLL POLL XRCC4 XRCC4 ESCO2 ESCO2 LMNA LMNA HELB HELB HUS1 HUS1 PARP1 PARP1 SLF1 SLF1 APLF APLF SMARCAL1 SMARCAL1 SMARCAD1 SMARCAD1 RPA3 RPA3 PARP3 PARP3 WAS WAS SETMAR SETMAR CYREN CYREN RNF168 RNF168 SMCHD1 SMCHD1 ARPC3 ARPC3 NABP2 NABP2 PNKP PNKP RNF169 RNF169 RBBP8 RBBP8 MRE11 MRE11 CNTD1 CNTD1 ENSPANP00000019650 ENSPANP00000019650 WRAP53 WRAP53 SMC5 SMC5 VCP VCP INIP INIP SMC6 SMC6 ARPC2 ARPC2 NABP1 NABP1 WDR70 WDR70 UFL1 UFL1 SIRT6 SIRT6 TONSL TONSL FAM178B FAM178B TIMELESS TIMELESS NHEJ1 NHEJ1 PHF1 PHF1 RNF8 RNF8 POLH POLH REC114 REC114 LOC100999046 LOC100999046 ZBTB7A ZBTB7A SAMHD1 SAMHD1 CGAS CGAS SIRT7 SIRT7 RAD18 RAD18 SHLD1 SHLD1 RIF1 RIF1 MAD2L2 MAD2L2 ARPC5 ARPC5 ENSPANP00000046766 ENSPANP00000046766 ENSPANP00000045505 ENSPANP00000045505 IFFO1 IFFO1 HUS1B HUS1B ENSPANP00000037673 ENSPANP00000037673 SLF2 SLF2 ARPC4 ARPC4 ENSPANP00000035124 ENSPANP00000035124 ENSPANP00000034674 ENSPANP00000034674 ACTR2 ACTR2 TP53 TP53 ACTR3 ACTR3 RAD51 RAD51 INTS3 INTS3 PAXX PAXX ENSPANP00000029311 ENSPANP00000029311 TP53BP1 TP53BP1 PRPF19 PRPF19 ENSPANP00000026514 ENSPANP00000026514
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
ENSPANP00000025644Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (161 aa)
SHLD2FAM35_C domain-containing protein. (924 aa)
ENSPANP00000022961Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (147 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
XRCC4X-ray repair cross complementing 4. (336 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (590 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
HELBDNA helicase B. (1087 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1035 aa)
APLFAprataxin and PNKP like factor. (511 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (951 aa)
SMARCAD1Uncharacterized protein. (1027 aa)
RPA3Uncharacterized protein. (121 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
WASWASP actin nucleation promoting factor. (486 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
CYRENCell cycle regulator of NHEJ. (158 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
RNF169Ring finger protein 169. (708 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
CNTD1Cyclin N-terminal domain containing 1. (330 aa)
ENSPANP00000019650Uncharacterized protein. (121 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
SMC5SMC_N domain-containing protein. (1201 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (808 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
SMC6Structural maintenance of chromosomes 6. (1092 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
WDR70WD repeat domain 70. (652 aa)
UFL1UFM1 specific ligase 1. (793 aa)
SIRT6Sirtuin 6. (355 aa)
TONSLTonsoku like, DNA repair protein. (1382 aa)
FAM178BFamily with sequence similarity 178 member B. (679 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
NHEJ1Non-homologous end joining factor 1. (316 aa)
PHF1PHD finger protein 1. (567 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
POLHDNA polymerase eta. (712 aa)
REC114REC114 meiotic recombination protein. (265 aa)
LOC100999046Replication protein A 14 kDa subunit. (121 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
SAMHD1Uncharacterized protein. (637 aa)
CGASMab-21 domain-containing protein. (522 aa)
SIRT7Sirtuin 7. (400 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (224 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
ENSPANP00000046766Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (153 aa)
ENSPANP00000045505Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (377 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (571 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
ENSPANP00000037673WD_REPEATS_REGION domain-containing protein. (336 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1184 aa)
ARPC4Uncharacterized protein. (279 aa)
ENSPANP00000035124Uncharacterized protein. (87 aa)
ENSPANP00000034674Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (169 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
INTS3Integrator complex subunit 3. (1097 aa)
PAXXPAXX non-homologous end joining factor. (209 aa)
ENSPANP00000029311Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (130 aa)
TP53BP1Uncharacterized protein. (1932 aa)
PRPF19Pre-mRNA processing factor 19. (512 aa)
ENSPANP00000026514FAM35_C domain-containing protein. (206 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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