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IFI16 IFI16 PRKAA1 PRKAA1 ENSPANP00000045079 ENSPANP00000045079 PIK3C3 PIK3C3 SLC7A5 SLC7A5 SESN3 SESN3 ENSPANP00000039443 ENSPANP00000039443 NFE2L2 NFE2L2 BRSK2 BRSK2 TP53 TP53 SLC2A1 SLC2A1 XBP1 XBP1 ENSPANP00000021624 ENSPANP00000021624 SIRT1 SIRT1 MYBBP1A MYBBP1A HSPA5 HSPA5 PLIN2 PLIN2 ATG14 ATG14 NIM1K NIM1K ATF4 ATF4 PICK1 PICK1 MTMR3 MTMR3 SIK1 SIK1 C12orf66 C12orf66 CHKA CHKA SESN2 SESN2 PRKAG2 PRKAG2 IMPACT IMPACT KPTN KPTN CPEB4 CPEB4 LOC101003421 LOC101003421 SZT2 SZT2 NUAK1 NUAK1 BRSK1 BRSK1 BHLHA15 BHLHA15 PLIN3 PLIN3 TBL2 TBL2 KAT5 KAT5 PRKAA2 PRKAA2 UPP1 UPP1 RRP8 RRP8 NUAK2 NUAK2 PIK3R4 PIK3R4 ZC3H12A ZC3H12A PRKAG3 PRKAG3 EIF2AK3 EIF2AK3 ITFG2 ITFG2 PRKAG1 PRKAG1 SESN1 SESN1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFI16Interferon gamma inducible protein 16. (727 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSPANP00000045079Uncharacterized protein. (111 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (897 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
SESN3Sestrin 3. (530 aa)
ENSPANP00000039443Uncharacterized protein; Belongs to the heat shock protein 70 family. (552 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (596 aa)
BRSK2BR serine/threonine kinase 2. (760 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (504 aa)
XBP1BZIP domain-containing protein. (380 aa)
ENSPANP00000021624BZIP domain-containing protein. (322 aa)
SIRT1Sirtuin 1. (743 aa)
MYBBP1AMYB binding protein 1a. (1338 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (592 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
ATG14Autophagy related 14. (510 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
ATF4Activating transcription factor 4. (351 aa)
PICK1Protein interacting with PRKCA 1. (377 aa)
MTMR3Myotubularin related protein 3. (1207 aa)
SIK1Uncharacterized protein. (785 aa)
C12orf66Chromosome 12 open reading frame 66. (468 aa)
CHKACholine kinase alpha. (452 aa)
SESN2Sestrin 2. (480 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
IMPACTImpact RWD domain protein. (320 aa)
KPTNKaptin, actin binding protein. (436 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
LOC101003421BZIP domain-containing protein. (371 aa)
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
NUAK1NUAK family kinase 1. (667 aa)
BRSK1BR serine/threonine kinase 1. (794 aa)
BHLHA15Basic helix-loop-helix family member a15. (193 aa)
PLIN3Perilipin; Belongs to the perilipin family. (412 aa)
TBL2Transducin beta like 2. (446 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
NUAK2NUAK family kinase 2. (671 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (340 aa)
SESN1Sestrin 1. (551 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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