STRINGSTRING
DLX2 DLX2 FGF4 FGF4 FGF10 FGF10 ITGB6 ITGB6 SLC34A1 SLC34A1 FAM20C FAM20C HAND1 HAND1 TBX1 TBX1 ENAM ENAM CTNNA1 CTNNA1 SCN10A SCN10A FST FST GATA6 GATA6 TGFB1 TGFB1 HDAC1 HDAC1 TRAF6 TRAF6 RELT RELT CTNNB1 CTNNB1 ANKRD11 ANKRD11 SCN5A SCN5A PERP PERP CFTR CFTR KLK4 KLK4 TCIRG1 TCIRG1 KLK5 KLK5 NECTIN1 NECTIN1 WNT6 WNT6 AMELX AMELX AMBN AMBN CNNM4 CNNM4 SLC24A4 SLC24A4 NF2 NF2 BCL11B BCL11B JAG2 JAG2 FOXC1 FOXC1 PPARA PPARA WDR72 WDR72 LAMA5 LAMA5 BMP7 BMP7 SMPD3 SMPD3 HDAC2 HDAC2 ODAM ODAM AMTN AMTN ACVR2A ACVR2A HTRA1 HTRA1 GLI2 GLI2 SMO SMO BMP4 BMP4 SHH SHH MMP20 MMP20 BCL2L11 BCL2L11 ENSPANP00000018240 ENSPANP00000018240 ATF2 ATF2 MSX1 MSX1 DLX1 DLX1 DLX3 DLX3 CCDC154 CCDC154 FAM20A FAM20A LHX8 LHX8 ENSPANP00000021910 ENSPANP00000021910 SERPINE1 SERPINE1 ADM ADM RUNX2 RUNX2 BSG BSG ENSPANP00000024775 ENSPANP00000024775 ACVR2B ACVR2B ENSPANP00000027020 ENSPANP00000027020 DSPP DSPP ENSPANP00000033198 ENSPANP00000033198 EDAR EDAR LEF1 LEF1 BAX BAX TP63 TP63 SOSTDC1 SOSTDC1 NKX2-3 NKX2-3 GLI3 GLI3 ROGDI ROGDI BMP2 BMP2 LRP4 LRP4 NGFR NGFR BMPR1A BMPR1A STIM1 STIM1 EDA EDA ENSPANP00000046574 ENSPANP00000046574
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX2Distal-less homeobox 2. (328 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (584 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TBX1T-box transcription factor 1. (491 aa)
ENAMEnamelin. (1139 aa)
CTNNA1Catenin alpha 1. (906 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
FSTFollistatin. (344 aa)
GATA6GATA binding protein 6. (595 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (455 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RELTRELT TNF receptor. (430 aa)
CTNNB1Catenin beta 1. (781 aa)
ANKRD11Ankyrin repeat domain 11. (2656 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (291 aa)
NECTIN1Nectin cell adhesion molecule 1. (519 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
AMELXUncharacterized protein. (205 aa)
AMBNAmeloblastin. (447 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (775 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
NF2Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (595 aa)
BCL11BB-cell CLL/lymphoma 11B, isoform 1 (Predicted). (894 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1213 aa)
FOXC1Fork-head domain-containing protein. (210 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
WDR72WD repeat domain 72. (1176 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (503 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
AMTNAmelotin. (208 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
GLI2GLI family zinc finger 2. (1552 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSPANP00000018240Uncharacterized protein. (179 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MSX1Msh homeobox 1. (284 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX3Distal-less homeobox 3. (280 aa)
CCDC154Coiled-coil domain containing 154. (674 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (533 aa)
LHX8LIM homeobox 8. (377 aa)
ENSPANP00000021910Uncharacterized protein. (822 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
ADMAdrenomedullin. (184 aa)
RUNX2RUNX family transcription factor 2. (611 aa)
BSGBasigin (Ok blood group). (380 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ENSPANP00000027020Hist_deacetyl domain-containing protein. (267 aa)
DSPPDentin sialophosphoprotein. (1013 aa)
ENSPANP00000033198Hist_deacetyl domain-containing protein. (225 aa)
EDAREctodysplasin A receptor. (515 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
NKX2-3NK2 homeobox 3. (365 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ROGDIRogdi atypical leucine zipper. (295 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
LRP4LDL receptor related protein 4. (1906 aa)
NGFRNerve growth factor receptor. (429 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
STIM1Stromal interaction molecule 1. (790 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
ENSPANP00000046574Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (452 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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