STRINGSTRING
NGF NGF CCND1 CCND1 PLXND1 PLXND1 RASA1 RASA1 GDNF GDNF POU4F1 POU4F1 HRAS HRAS XRCC4 XRCC4 PTK2B PTK2B MDK MDK BCL2 BCL2 ENSPANP00000001773 ENSPANP00000001773 GCLM GCLM PTPRZ1 PTPRZ1 NTRK1 NTRK1 THAP11 THAP11 DRAXIN DRAXIN SOD2 SOD2 NTF3 NTF3 SNCB SNCB F2R F2R RETREG1 RETREG1 PRKN PRKN KDM2B KDM2B PIK3CA PIK3CA MSH2 MSH2 ANGPT1 ANGPT1 NTF4 NTF4 AXL AXL CHL1 CHL1 EN2 EN2 HYOU1 HYOU1 LIG4 LIG4 SLC30A10 SLC30A10 STAMBP STAMBP PRKCI PRKCI NAIP NAIP FZD9 FZD9 CPEB4 CPEB4 MTNR1B MTNR1B ZPR1 ZPR1 IL27RA IL27RA VEGFB VEGFB FOXB1 FOXB1 KIF14 KIF14 XRCC2 XRCC2 CLN8 CLN8 NEFL NEFL NDNF NDNF CX3CL1 CX3CL1 TFAP2D TFAP2D GCLC GCLC GFRAL GFRAL LGMN LGMN PLA2G3 PLA2G3 CEBPB CEBPB KDR KDR IL6ST IL6ST AARS1 AARS1 SOD1 SOD1 HIPK2 HIPK2 FGF20 FGF20 TGFB3 TGFB3 ALKBH1 ALKBH1 BIRC5 BIRC5 GDF5 GDF5 BCL2L1 BCL2L1 ADORA2A ADORA2A BHLHB9 BHLHB9 AGAP2 AGAP2 HDGF HDGF NES NES PINK1 PINK1 WFS1 WFS1 DLX1 DLX1 PPARGC1A PPARGC1A BRAF BRAF BARHL1 BARHL1 CNTFR CNTFR SLC1A1 SLC1A1 MAP2K4 MAP2K4 NRP1 NRP1 UNC5B UNC5B FGF8 FGF8 ROCK1 ROCK1 ENSPANP00000021036 ENSPANP00000021036 MAG MAG PRKCG PRKCG AMBRA1 AMBRA1 VPS54 VPS54 CLCF1 CLCF1 TFAP2B TFAP2B BTG2 BTG2 CX3CR1 CX3CR1 FAIM2 FAIM2 ISL1 ISL1 HIF1A HIF1A BOK BOK GRN GRN ENSPANP00000028905 ENSPANP00000028905 EN1 EN1 PPT1 PPT1 PARK7 PARK7 NRBP2 NRBP2 CRLF1 CRLF1 SYNGAP1 SYNGAP1 NR4A2 NR4A2 VSTM2L VSTM2L OXR1 OXR1 TYRO3 TYRO3 NTRK2 NTRK2 SIX4 SIX4 MAP3K12 MAP3K12 CORO1A CORO1A SIX1 SIX1 CITED1 CITED1 BAX BAX ERBB3 ERBB3 GABRA5 GABRA5 ADNP ADNP NFATC4 NFATC4 SEMA3E SEMA3E RHOA RHOA ADAM8 ADAM8 MECP2 MECP2 MT3 MT3 GBE1 GBE1 DNAJC5 DNAJC5 NONO NONO GABRB2 GABRB2 BDNF BDNF GRIK2 GRIK2 DNAJC5B DNAJC5B JUND JUND MEF2C MEF2C KRAS KRAS TERT TERT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PLXND1Plexin D1. (1924 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
POU4F1POU domain protein. (414 aa)
HRASUncharacterized protein. (189 aa)
XRCC4X-ray repair cross complementing 4. (336 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
MDKMidkine. (161 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2314 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
THAP11THAP domain containing 11. (307 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
RETREG1Reticulophagy regulator 1. (497 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
KDM2BLysine demethylase 2B. (1338 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (905 aa)
ANGPT1Angiopoietin 1. (498 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
EN2Homeobox protein engrailed-like. (311 aa)
HYOU1Hypoxia up-regulated 1. (985 aa)
LIG4DNA ligase. (911 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
STAMBPSTAM binding protein. (427 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
NAIPNLR family apoptosis inhibitory protein. (1372 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ZPR1Zinc finger protein ZPR1; Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity). (459 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FOXB1Forkhead box B1. (325 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1640 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
TFAP2DTranscription factor AP-2 delta. (452 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
GFRALGDNF family receptor alpha like. (394 aa)
LGMNLegumain. (433 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1315 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
HIPK2Homeodomain interacting protein kinase 2. (1158 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
BIRC5Uncharacterized protein. (144 aa)
GDF5Growth differentiation factor 5 (Predicted). (499 aa)
BCL2L1BCL2 like 1. (233 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
BHLHB9Arm_2 domain-containing protein. (547 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
HDGFHeparin binding growth factor. (256 aa)
NESNestin; Belongs to the intermediate filament family. (1619 aa)
PINK1PTEN induced kinase 1. (581 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
DLX1Distal-less homeobox 1. (255 aa)
PPARGC1APPARG coactivator 1 alpha. (793 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
BARHL1BarH like homeobox 1. (358 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (466 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ENSPANP00000021036NGF domain-containing protein; Belongs to the NGF-beta family. (197 aa)
MAGMyelin associated glycoprotein. (772 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1308 aa)
VPS54VPS54 subunit of GARP complex. (966 aa)
CLCF1Cardiotrophin like cytokine factor 1. (230 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (315 aa)
ISL1ISL LIM homeobox 1. (395 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (832 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
GRNGranulin precursor. (613 aa)
ENSPANP00000028905RRM domain-containing protein. (449 aa)
EN1Homeobox protein engrailed-like. (396 aa)
PPT1Palmitoyl-protein thioesterase 1. (334 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
NRBP2Nuclear receptor binding protein 2. (519 aa)
CRLF1Cytokine receptor like factor 1. (459 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1328 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (580 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (204 aa)
OXR1Oxidation resistance 1. (874 aa)
TYRO3TYRO3 protein tyrosine kinase. (902 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
SIX4SIX homeobox 4. (780 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (487 aa)
SIX1SIX homeobox 1. (284 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1350 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
RHOARas homolog family member A. (193 aa)
ADAM8ADAM metallopeptidase domain 8. (902 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
GBE11,4-alpha-glucan branching enzyme 1. (708 aa)
DNAJC5J domain-containing protein. (219 aa)
NONONon-POU domain containing octamer binding. (490 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (912 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (309 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1152 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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