STRINGSTRING
P4HTM P4HTM FOXP1 FOXP1 PRMT1 PRMT1 TESC TESC LEF1 LEF1 CDC73 CDC73 STAT3 STAT3 PRDM16 PRDM16 MTURN MTURN C1QC C1QC ENSPANP00000046779 ENSPANP00000046779 MEIS1 MEIS1 MEF2C MEF2C EIF6 EIF6 ENSPANP00000044875 ENSPANP00000044875 MEIS2 MEIS2 RARA RARA STAT5B STAT5B ENSPANP00000042087 ENSPANP00000042087 IL34 IL34 PPP3CA PPP3CA GPR68 GPR68 RARG RARG HSF1 HSF1 ENSPANP00000040056 ENSPANP00000040056 GPR137 GPR137 CTNNBIP1 CTNNBIP1 CEACAM1 CEACAM1 CD74 CD74 POU4F1 POU4F1 PIK3R1 PIK3R1 PTK2B PTK2B PPARGC1B PPARGC1B IFNG IFNG IRF7 IRF7 ARNT ARNT SFRP1 SFRP1 TLR3 TLR3 NDFIP1 NDFIP1 CREB1 CREB1 LOC110741840 LOC110741840 FBXW7 FBXW7 TNFAIP6 TNFAIP6 TAL1 TAL1 CTR9 CTR9 KITLG KITLG IL12B IL12B HSPA9 HSPA9 CARTPT CARTPT TMEM178A TMEM178A TGFB1 TGFB1 CD4 CD4 NOTCH2 NOTCH2 LYN LYN TRAF6 TRAF6 GPR171 GPR171 CASP8 CASP8 CTNNB1 CTNNB1 SLC9B2 SLC9B2 LOX LOX MPL MPL DLL1 DLL1 LRRC17 LRRC17 LTF LTF FAXDC2 FAXDC2 TRIB1 TRIB1 HMGB3 HMGB3 ITPKB ITPKB CLDN18 CLDN18 TNFRSF11B TNFRSF11B LOC101020237 LOC101020237 TCTA TCTA KLF10 KLF10 GATA1 GATA1 FBXW9 FBXW9 GATA2 GATA2 HOXA5 HOXA5 PF4 PF4 ACIN1 ACIN1 PTPN2 PTPN2 ZFP36 ZFP36 GPR137B GPR137B UBASH3B UBASH3B MYC MYC INHA INHA PRMT6 PRMT6 THPO THPO CAMK4 CAMK4 DCSTAMP DCSTAMP FADD FADD ENSPANP00000009979 ENSPANP00000009979 RHEX RHEX IL20 IL20 RBM15 RBM15 ZBTB16 ZBTB16 CD101 CD101 GABPA GABPA MYB MYB CDK6 CDK6 PAF1 PAF1 RAB7B RAB7B IAPP IAPP NCKAP1L NCKAP1L CUL4A CUL4A CALCA CALCA IL23A IL23A MAPK14 MAPK14 TREM2 TREM2 IL17A IL17A GAS2L1 GAS2L1 LIF LIF PLA2G3 PLA2G3 RCOR1 RCOR1 ANKRD54 ANKRD54 FES FES RIPK1 RIPK1 BRD1 BRD1 B2M B2M FBN1 FBN1 LEO1 LEO1 WDR61 WDR61 CIB1 CIB1 FAM210B FAM210B CEBPB CEBPB INPP5D INPP5D HAX1 HAX1 ESRRA ESRRA SCIN SCIN APCS APCS PRKDC PRKDC POU4F2 POU4F2 INHBA INHBA CSF3R CSF3R MTOR MTOR ACVR1B ACVR1B FOS FOS ACVR2A ACVR2A PRKCA PRKCA RASSF2 RASSF2 JAG1 JAG1 ZFP36L1 ZFP36L1 PITHD1 PITHD1 MAFB MAFB ZNF16 ZNF16 HCLS1 HCLS1 ABCB10 ABCB10 CNOT4 CNOT4 ENSPANP00000017998 ENSPANP00000017998 OCSTAMP OCSTAMP RB1 RB1 CSF1 CSF1 IL23R IL23R FSHR FSHR ZFPM1 ZFPM1 ENSPANP00000019082 ENSPANP00000019082 ROR2 ROR2 NINJ1 NINJ1 ENSPANP00000019901 ENSPANP00000019901 NF1 NF1 LOC100999050 LOC100999050 HOXB8 HOXB8 PRXL2A PRXL2A MED1 MED1 CSF3 CSF3 TNFSF11 TNFSF11 RBP1 RBP1 LOC103887915 LOC103887915 FSTL3 FSTL3 ENSPANP00000023895 ENSPANP00000023895 TMEM64 TMEM64 RUNX1 RUNX1 NEDD9 NEDD9 ENSPANP00000026331 ENSPANP00000026331 STAT1 STAT1 ETS1 ETS1 HIF1A HIF1A PIAS3 PIAS3 ADIPOQ ADIPOQ ENSPANP00000027949 ENSPANP00000027949 LDB1 LDB1 MITF MITF KAT7 KAT7 ZBTB46 ZBTB46 NFKBIA NFKBIA ISG15 ISG15 RNF41 RNF41
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P4HTMProlyl 4-hydroxylase, transmembrane. (554 aa)
FOXP1Forkhead box P1. (693 aa)
PRMT1Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (382 aa)
TESCTescalcin. (214 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CDC73Cell division cycle 73. (531 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRDM16PR/SET domain 16. (1186 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
C1QCComplement C1q C chain. (245 aa)
ENSPANP00000046779DUF1279 domain-containing protein. (164 aa)
MEIS1Meis homeobox 1. (465 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (269 aa)
ENSPANP00000044875Uncharacterized protein. (202 aa)
MEIS2Meis homeobox 2. (477 aa)
RARARetinoic acid receptor alpha. (478 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
ENSPANP00000042087Nuclear receptor domain-containing protein. (249 aa)
IL34Interleukin 34. (242 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
RARGRetinoic acid receptor gamma. (463 aa)
HSF1Heat shock transcription factor 1. (532 aa)
ENSPANP00000040056Uncharacterized protein. (123 aa)
GPR137G protein-coupled receptor 137. (447 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CEACAM1Uncharacterized protein. (525 aa)
CD74CD74 molecule. (294 aa)
POU4F1POU domain protein. (414 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
IRF7Interferon regulatory factor 7. (504 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LOC110741840Uncharacterized protein. (591 aa)
FBXW7F-box and WD repeat domain containing 7. (706 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
HSPA9Uncharacterized protein; Belongs to the heat shock protein 70 family. (679 aa)
CARTPTCART prepropeptide. (116 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CD4CD4 molecule. (458 aa)
NOTCH2Notch receptor 2. (2603 aa)
LYNTyrosine-protein kinase. (512 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
GPR171G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CTNNB1Catenin beta 1. (781 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
LOXLysyl oxidase. (417 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
LRRC17Leucine rich repeat containing 17. (441 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (349 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
HMGB3Uncharacterized protein. (201 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (947 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
LOC101020237C-C motif chemokine. (92 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
KLF10Kruppel like factor 10. (480 aa)
GATA1GATA binding protein 1. (413 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
GATA2GATA binding protein 2. (480 aa)
HOXA5Homeobox A5 (Predicted). (270 aa)
PF4C-X-C motif chemokine. (101 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1339 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
GPR137BG protein-coupled receptor 137B. (384 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
PRMT6Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
THPOThrombopoietin. (351 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ENSPANP00000009979Uncharacterized protein. (314 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (178 aa)
IL20Interleukin 20. (176 aa)
RBM15RNA binding motif protein 15. (977 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
CD101CD101 molecule. (1021 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (530 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
IAPPIslet amyloid polypeptide. (89 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
CUL4ACullin 4A; Belongs to the cullin family. (763 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL17AInterleukin 17A. (155 aa)
GAS2L1Growth arrest specific 2 like 1. (681 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
RCOR1REST corepressor 1. (486 aa)
ANKRD54Ankyrin repeat domain 54. (174 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (816 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (776 aa)
BRD1Bromodomain containing 1. (1058 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
FBN1Fibrillin 1. (2871 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
WDR61WD repeat domain 61. (305 aa)
CIB1Calcium and integrin binding 1. (191 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1188 aa)
HAX1HCLS1 associated protein X-1. (287 aa)
ESRRAEstrogen related receptor alpha. (423 aa)
SCINScinderin. (715 aa)
APCSPentaxin. (223 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4094 aa)
POU4F2POU domain protein. (408 aa)
INHBAInhibin subunit beta A. (426 aa)
CSF3RColony stimulating factor 3 receptor. (836 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RASSF2Ras association domain family member 2. (326 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1190 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
PITHD1PITH domain containing 1. (211 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
ZNF16Zinc finger protein 16. (682 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (713 aa)
ENSPANP00000017998Uncharacterized protein; Belongs to the heat shock protein 70 family. (555 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (555 aa)
RB1RB transcriptional corepressor 1. (889 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
IL23RInterleukin 23 receptor. (629 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1002 aa)
ENSPANP00000019082Uncharacterized protein. (200 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
NINJ1Ninjurin 1. (152 aa)
ENSPANP00000019901Uncharacterized protein. (195 aa)
NF1Neurofibromin 1. (2839 aa)
LOC100999050C-C motif chemokine. (92 aa)
HOXB8Homeobox B8. (254 aa)
PRXL2APeroxiredoxin like 2A. (229 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1548 aa)
CSF3Colony stimulating factor 3. (207 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (197 aa)
LOC103887915Uncharacterized protein. (245 aa)
FSTL3Follistatin like 3. (265 aa)
ENSPANP00000023895Uncharacterized protein. (191 aa)
TMEM64Transmembrane protein 64. (380 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ENSPANP00000026331Uncharacterized protein; Belongs to the heat shock protein 70 family. (556 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (832 aa)
PIAS3Protein inhibitor of activated STAT 3. (634 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
ENSPANP00000027949Uncharacterized protein. (188 aa)
LDB1LIM domain binding 1. (411 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
RNF41Ring finger protein 41. (317 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
Server load: low (24%) [HD]