STRINGSTRING
MED31 MED31 BAX BAX PARP10 PARP10 CDC73 CDC73 TP53 TP53 PAWR PAWR IFI30 IFI30 ING5 ING5 DAB2IP DAB2IP LZTS2 LZTS2 NF1 NF1 CAV1 CAV1 SKI SKI NLRC3 NLRC3 MORC3 MORC3 NUPR1 NUPR1 TRIM32 TRIM32 B4GALT7 B4GALT7 TP53INP1 TP53INP1 DACH1 DACH1 MYC MYC C1QL4 C1QL4 MED25 MED25 PEX2 PEX2 EMD EMD SFRP1 SFRP1 FBXO4 FBXO4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
PARP10Poly [ADP-ribose] polymerase. (1037 aa)
CDC73Cell division cycle 73. (531 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
PAWRPro-apoptotic WT1 regulator. (342 aa)
IFI30IFI30 lysosomal thiol reductase. (250 aa)
ING5Inhibitor of growth family member 5. (253 aa)
DAB2IPDAB2 interacting protein. (1183 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
NF1Neurofibromin 1. (2839 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
SKISKI proto-oncogene. (700 aa)
NLRC3NLR family CARD domain containing 3. (1024 aa)
MORC3MORC family CW-type zinc finger 3. (932 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
TRIM32Tripartite motif containing 32. (653 aa)
B4GALT7Beta-1,4-galactosyltransferase 7. (327 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
DACH1Dachshund family transcription factor 1. (761 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
C1QL4Complement C1q like 4. (238 aa)
MED25Mediator complex subunit 25. (747 aa)
PEX2Peroxisomal biogenesis factor 2. (323 aa)
EMDLEM domain-containing protein. (255 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FBXO4F-box protein 4. (390 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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