STRINGSTRING
TBX20 TBX20 LPAR3 LPAR3 WNT2 WNT2 ACACB ACACB IL7 IL7 ENSPANP00000007050 ENSPANP00000007050 RAG2 RAG2 CRABP2 CRABP2 SYT3 SYT3 SASH3 SASH3 YBX3 YBX3 MAP3K13 MAP3K13 NRP1 NRP1 HLX HLX INSR INSR BMP10 BMP10 DBN1 DBN1 PLS1 PLS1 GOLGA4 GOLGA4 NOL12 NOL12 AKAP6 AKAP6 BCL11A BCL11A EZR EZR TBX5 TBX5 CAPN3 CAPN3 NRG1 NRG1 MUL1 MUL1 SEMA5A SEMA5A GHRHR GHRHR BASP1 BASP1 ATP8A2 ATP8A2 MAP1B MAP1B GHSR GHSR RASAL1 RASAL1 NGF NGF ENSPANP00000047252 ENSPANP00000047252 MEF2C MEF2C ACTN3 ACTN3 DRD2 DRD2 ZFPM2 ZFPM2 AGR2 AGR2 MACF1 MACF1 BDNF BDNF LIMK1 LIMK1 CDKL5 CDKL5 HEY2 HEY2 VIL1 VIL1 DISC1 DISC1 STAT5B STAT5B BMPR1A BMPR1A RIMS2 RIMS2 LOC101018182 LOC101018182 FN1 FN1 UNC13A UNC13A IGF1 IGF1 WT1 WT1 CXCL12 CXCL12 YAP1 YAP1 HOPX HOPX TGFBR3 TGFBR3 PPARD PPARD MAPK14 MAPK14 CPNE5 CPNE5 PIM1 PIM1 SRF SRF BBS2 BBS2 AKT1 AKT1 EDN1 EDN1 RPS6KB1 RPS6KB1 MEGF8 MEGF8 ZFYVE27 ZFYVE27 PEX5 PEX5 TSHR TSHR DSCAM DSCAM L1CAM L1CAM TWF2 TWF2 ENSPANP00000024775 ENSPANP00000024775 FGF9 FGF9 GHRL GHRL GPAM GPAM FGFR2 FGFR2 ITSN2 ITSN2 ENSPANP00000021907 ENSPANP00000021907 FGF8 FGF8 MAPT MAPT WNT3 WNT3 RND2 RND2 TBX2 TBX2 CHD7 CHD7 ARX ARX GHR GHR SLC6A3 SLC6A3 MYOD1 MYOD1 PROX1 PROX1 BCL2 BCL2 CREB1 CREB1 SYT1 SYT1 NIPBL NIPBL ERBB4 ERBB4 GLI1 GLI1 LOC101006360 LOC101006360 EFNA5 EFNA5 SYT4 SYT4 RNF157 RNF157 CYFIP1 CYFIP1 NOTCH1 NOTCH1 DBNL DBNL POU4F2 POU4F2 SYT17 SYT17 RIMS1 RIMS1 TRPC5 TRPC5 SYT2 SYT2 WNT3A WNT3A ADNP ADNP PARP2 PARP2 CDH4 CDH4 SEMA7A SEMA7A BBS4 BBS4 PPIB PPIB GATA6 GATA6 IGF2 IGF2 LEP LEP PRKN PRKN TRPV2 TRPV2 SOX15 SOX15 AGRN AGRN SEMA4D SEMA4D PLAA PLAA SMURF1 SMURF1 CSF1 CSF1 GHRH GHRH ANAPC2 ANAPC2 MKKS MKKS PLCB1 PLCB1 SLC23A2 SLC23A2 SMO SMO SHTN1 SHTN1 SPTBN4 SPTBN4 SMAD7 SMAD7 RUFY3 RUFY3 DLL1 DLL1 BMPR2 BMPR2 CACNG7 CACNG7 CPNE9 CPNE9 TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX20T-box transcription factor 20. (447 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
ENSPANP00000007050Uncharacterized protein. (502 aa)
RAG2Recombination activating 2. (532 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
SYT3Synaptotagmin 3. (590 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
YBX3Y-box binding protein 3. (372 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
HLXH2.0 like homeobox. (494 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
DBN1Drebrin 1. (695 aa)
PLS1Plastin 1. (629 aa)
GOLGA4Golgin A4. (2202 aa)
NOL12Uncharacterized protein. (212 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (838 aa)
EZREzrin. (603 aa)
TBX5T-box transcription factor 5. (518 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
NRG1Neuregulin 1. (713 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
SEMA5ASemaphorin 5A. (1074 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (468 aa)
BASP1Uncharacterized protein. (110 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
MAP1BMicrotubule associated protein 1B. (2485 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RASAL1RAS protein activator like 1. (806 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
ENSPANP00000047252Uncharacterized protein; Belongs to the parvalbumin family. (110 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (959 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (188 aa)
MACF1Microtubule actin crosslinking factor 1. (7518 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
LIMK1LIM domain kinase 1. (677 aa)
CDKL5Cyclin dependent kinase like 5. (1009 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (326 aa)
VIL1Villin 1. (830 aa)
DISC1DISC1 scaffold protein. (704 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
LOC101018182Microtubule-associated protein. (346 aa)
FN1Fibronectin 1. (2477 aa)
UNC13AUnc-13 homolog A. (1581 aa)
IGF1Insulin like growth factor 1. (208 aa)
WT1WT1 transcription factor. (510 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
YAP1Yes associated protein 1. (506 aa)
HOPXHOP homeobox. (109 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CPNE5Copine 5. (610 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
SRFSerum response factor. (508 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EDN1Endothelin 1. (211 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MEGF8Multiple EGF like domains 8. (2825 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
PEX5TPR_REGION domain-containing protein. (660 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
DSCAMDS cell adhesion molecule. (2010 aa)
L1CAML1 cell adhesion molecule, isoform 1 (Predicted). (1324 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GHRLGhrelin and obestatin prepropeptide. (133 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ITSN2Intersectin 2. (1688 aa)
ENSPANP00000021907Uncharacterized protein. (509 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MAPTMicrotubule-associated protein. (776 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RND2Rho family GTPase 2. (227 aa)
TBX2T-box transcription factor 2. (704 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
ARXAristaless related homeobox. (516 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (645 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
PROX1Prospero homeobox 1. (737 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SYT1Synaptotagmin 1. (422 aa)
NIPBLNipped-B protein. (2776 aa)
ERBB4Receptor protein-tyrosine kinase. (1224 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LOC101006360C-type lectin domain-containing protein. (166 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
SYT4Synaptotagmin 4. (425 aa)
RNF157Ring finger protein 157. (679 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
NOTCH1Notch receptor 1. (2541 aa)
DBNLDrebrin like. (440 aa)
POU4F2POU domain protein. (408 aa)
SYT17Synaptotagmin 17. (474 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
SYT2Synaptotagmin 2. (419 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
PARP2Poly [ADP-ribose] polymerase. (575 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GATA6GATA binding protein 6. (595 aa)
IGF2IlGF domain-containing protein. (245 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
SOX15SRY-box transcription factor 15. (233 aa)
AGRNAgrin. (2077 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
PLAAPhospholipase A2 activating protein. (795 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa)
SLC23A2Solute carrier family 23 member 2. (650 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SHTN1Shootin 1. (636 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
RUFY3RUN and FYVE domain containing 3. (620 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CPNE9Copine family member 9. (553 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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