STRINGSTRING
CTSH CTSH TMEM59L TMEM59L PLXND1 PLXND1 FGF10 FGF10 GDNF GDNF BCL2 BCL2 SFRP2 SFRP2 DAG1 DAG1 RASIP1 RASIP1 WNT4 WNT4 EPHA2 EPHA2 ESRP2 ESRP2 TBX3 TBX3 TGFB1 TGFB1 NRARP NRARP CASR CASR FOXC2 FOXC2 CSMD2 CSMD2 GREB1L GREB1L PKD2 PKD2 PBX1 PBX1 TIE1 TIE1 CTNNB1 CTNNB1 COL4A1 COL4A1 FOXF1 FOXF1 LAMA1 LAMA1 WNT5A WNT5A TGFBR2 TGFBR2 AR AR EDNRA EDNRA TBX20 TBX20 PAK1 PAK1 SMAD4 SMAD4 HOXA5 HOXA5 VDR VDR SPRY2 SPRY2 FGF1 FGF1 GBX2 GBX2 NKX3-1 NKX3-1 EGF EGF EYA1 EYA1 DCHS1 DCHS1 RBM15 RBM15 ADAMTS16 ADAMTS16 PPP1CA PPP1CA WNT6 WNT6 CLIC4 CLIC4 HOXA11 HOXA11 TCF21 TCF21 RDH10 RDH10 RSPO2 RSPO2 SPRY1 SPRY1 TIMELESS TIMELESS NOTCH4 NOTCH4 SALL1 SALL1 SRF SRF PKHD1 PKHD1 GREB1 GREB1 CELSR1 CELSR1 EDN1 EDN1 PKD1 PKD1 PML PML LAMA5 LAMA5 CTSZ CTSZ BMP7 BMP7 KDR KDR IHH IHH ESR1 ESR1 GDF7 GDF7 EXT1 EXT1 ENSPANP00000015490 ENSPANP00000015490 NOTCH1 NOTCH1 MMP14 MMP14 GNA13 GNA13 GLI2 GLI2 FOXA1 FOXA1 BMP4 BMP4 PLEKHH1 PLEKHH1 GZF1 GZF1 SHH SHH FGF2 FGF2 CSF1 CSF1 WNT1 WNT1 PTCH1 PTCH1 HS3ST3A1 HS3ST3A1 HS3ST3B1 HS3ST3B1 NRP1 NRP1 DLG5 DLG5 TBX2 TBX2 MED1 MED1 WNT9B WNT9B PAX2 PAX2 FGF8 FGF8 GDF2 GDF2 PPP3R1 PPP3R1 ACVR1 ACVR1 FGFR2 FGFR2 BTRC BTRC NKX2-1 NKX2-1 FOXD1 FOXD1 KDM5B KDM5B SRC SRC LRP5 LRP5 MET MET SLIT2 SLIT2 CSMD1 CSMD1 ENSPANP00000031315 ENSPANP00000031315 DSPP DSPP DDR1 DDR1 LEF1 LEF1 SIX1 SIX1 CITED1 CITED1 ENG ENG YAP1 YAP1 DLG1 DLG1 WT1 WT1 GLI3 GLI3 CTNNBIP1 CTNNBIP1 NFATC4 NFATC4 SEMA3E SEMA3E BMP2 BMP2 PGF PGF HHIP HHIP AREG AREG DLL4 DLL4 MKS1 MKS1 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSHCathepsin H; Belongs to the peptidase C1 family. (324 aa)
TMEM59LTransmembrane protein 59 like. (331 aa)
PLXND1Plexin D1. (1924 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
DAG1Dystroglycan 1. (893 aa)
RASIP1Ras interacting protein 1. (946 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EPHA2EPH receptor A2. (976 aa)
ESRP2Epithelial splicing regulatory protein 2. (725 aa)
TBX3T-box transcription factor 3. (743 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
CASRCalcium sensing receptor. (1081 aa)
FOXC2Forkhead box C2. (494 aa)
CSMD2CUB and Sushi multiple domains 2. (3613 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1881 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
PBX1PBX homeobox 1. (430 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
CTNNB1Catenin beta 1. (781 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
FOXF1Forkhead box F1. (432 aa)
LAMA1Laminin subunit alpha 1. (3024 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ARAndrogen receptor. (896 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TBX20T-box transcription factor 20. (447 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
HOXA5Homeobox A5 (Predicted). (270 aa)
VDRVitamin D receptor. (544 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NKX3-1NK3 homeobox 1. (232 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
RBM15RNA binding motif protein 15. (977 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1215 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
HOXA11Homeobox A11 (Predicted). (311 aa)
TCF21Transcription factor 21. (179 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
RSPO2R-spondin 2. (243 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
NOTCH4Notch receptor 4. (2000 aa)
SALL1Spalt like transcription factor 1. (1318 aa)
SRFSerum response factor. (508 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4072 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2868 aa)
EDN1Endothelin 1. (211 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4297 aa)
PMLPromyelocytic leukemia. (882 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1315 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GDF7Growth differentiation factor 7. (447 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
ENSPANP00000015490Uncharacterized protein. (88 aa)
NOTCH1Notch receptor 1. (2541 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
GNA13G protein subunit alpha 13. (377 aa)
GLI2GLI family zinc finger 2. (1552 aa)
FOXA1Forkhead box A1. (470 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1364 aa)
GZF1GDNF inducible zinc finger protein 1. (712 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PTCH1Patched 1. (1452 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
TBX2T-box transcription factor 2. (704 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1548 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PAX2Paired box 2. (436 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
GDF2Growth differentiation factor 2. (429 aa)
PPP3R1Uncharacterized protein. (189 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
NKX2-1NK2 homeobox 1. (401 aa)
FOXD1Uncharacterized protein. (417 aa)
KDM5BLysine demethylase 5B. (1580 aa)
SRCTyrosine-protein kinase. (644 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1404 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CSMD1CUB and Sushi multiple domains 1. (3500 aa)
ENSPANP00000031315Homeobox domain-containing protein. (140 aa)
DSPPDentin sialophosphoprotein. (1013 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (920 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
SIX1SIX homeobox 1. (284 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
ENGZP domain-containing protein. (274 aa)
YAP1Yes associated protein 1. (506 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
WT1WT1 transcription factor. (510 aa)
GLI3GLI family zinc finger 3. (1580 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (184 aa)
HHIPHedgehog interacting protein. (700 aa)
AREGAmphiregulin. (274 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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