STRINGSTRING
DACH1 DACH1 SFN SFN WNT16 WNT16 HLX HLX FGF1 FGF1 KRT2 KRT2 IQGAP3 IQGAP3 EHF EHF WNT2 WNT2 MTA3 MTA3 IFT172 IFT172 SDR16C5 SDR16C5 THAP1 THAP1 CD109 CD109 AR AR WDR77 WDR77 BMPR2 BMPR2 WNT5A WNT5A COL8A2 COL8A2 KDF1 KDF1 CTNNB1 CTNNB1 IGFBP5 IGFBP5 NOTCH2 NOTCH2 NRARP NRARP TGFB1 TGFB1 ESRP2 ESRP2 EPHA2 EPHA2 FAP FAP LGR5 LGR5 A4GNT A4GNT FST FST MTSS1 MTSS1 ST8SIA1 ST8SIA1 STAT6 STAT6 FABP7 FABP7 NKX2-6 NKX2-6 HGF HGF NOG NOG CLEC12B CLEC12B PDX1 PDX1 RETNLB RETNLB PROK1 PROK1 PROX1 PROX1 FGL1 FGL1 FGF10 FGF10 BAD BAD CCND1 CCND1 TGFBR1 TGFBR1 PROK2 PROK2 MEF2C MEF2C LOXL2 LOXL2 DRD2 DRD2 EAF2 EAF2 EFNB2 EFNB2 NCSTN NCSTN PSEN1 PSEN1 BTBD10 BTBD10 STK3 STK3 AREG AREG BMPR1A BMPR1A BMPER BMPER ID2 ID2 BAK1 BAK1 SERPINB1 SERPINB1 C6orf89 C6orf89 DLG1 DLG1 TP63 TP63 YAP1 YAP1 TGFA TGFA BAX BAX LIMS2 LIMS2 CCN3 CCN3 PIK3CB PIK3CB NOX5 NOX5 RPS6KA1 RPS6KA1 SEMA5A SEMA5A IGFBP3 IGFBP3 LGR4 LGR4 XBP1 XBP1 HSF4 HSF4 SCARB1 SCARB1 RASGRF1 RASGRF1 SIDT2 SIDT2 MAPK1 MAPK1 ENSPANP00000024775 ENSPANP00000024775 FGF9 FGF9 BTRC BTRC CDKN1B CDKN1B FGFR2 FGFR2 IL6 IL6 ENSPANP00000022457 ENSPANP00000022457 RUNX2 RUNX2 TNFSF11 TNFSF11 IRS2 IRS2 KLK8 KLK8 IGFBP4 IGFBP4 LIPA LIPA MED1 MED1 TBX2 TBX2 VSTM4 VSTM4 ZEB1 ZEB1 NF1 NF1 FLCN FLCN SERPINF1 SERPINF1 PTCH1 PTCH1 IFT74 IFT74 TEK TEK B4GALT1 B4GALT1 KIT KIT FSHR FSHR RB1 RB1 AGAP2 AGAP2 IFT52 IFT52 SHH SHH FERMT1 FERMT1 BMP4 BMP4 BCL2L1 BCL2L1 SAV1 SAV1 NKX2-8 NKX2-8 SMO SMO EREG EREG CAV1 CAV1 SOX9 SOX9 HMX2 HMX2 ERN1 ERN1 MKI67 MKI67 ACVR2A ACVR2A FOXE3 FOXE3 NOTCH1 NOTCH1 ESR1 ESR1 PHOX2B PHOX2B KDR KDR CEBPB CEBPB FGF7 FGF7 ITGB1BP1 ITGB1BP1 PPARD PPARD CALCA CALCA TRIM24 TRIM24 IFT80 IFT80 IFT57 IFT57 OVOL1 OVOL1 COL8A1 COL8A1 NKX2-5 NKX2-5 CD34 CD34 LOC101003421 LOC101003421 EYA1 EYA1 STK11 STK11 IRF6 IRF6 EGF EGF NKX3-1 NKX3-1 LOC101022119 LOC101022119
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DACH1Dachshund family transcription factor 1. (761 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HLXH2.0 like homeobox. (494 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KRT2Keratin 2; Belongs to the intermediate filament family. (635 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
EHFETS homologous factor. (322 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
IFT172Intraflagellar transport 172. (1724 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
THAP1THAP domain containing 1. (212 aa)
CD109CD109 molecule. (1446 aa)
ARAndrogen receptor. (896 aa)
WDR77WD repeat domain 77. (342 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
COL8A2Collagen type VIII alpha 2 chain. (701 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CTNNB1Catenin beta 1. (781 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
NOTCH2Notch receptor 2. (2603 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ESRP2Epithelial splicing regulatory protein 2. (725 aa)
EPHA2EPH receptor A2. (976 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
FSTFollistatin. (344 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
NKX2-6NK2 homeobox 6. (301 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
RETNLBResistin like beta. (111 aa)
PROK1Prokineticin 1. (105 aa)
PROX1Prospero homeobox 1. (737 aa)
FGL1Fibrinogen like 1. (312 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BADBCL2 associated agonist of cell death. (168 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PROK2Prokineticin 2. (129 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
EAF2ELL associated factor 2. (263 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
NCSTNNicastrin. (721 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (452 aa)
BTBD10BTB domain containing 10. (483 aa)
STK3Serine/threonine kinase 3. (534 aa)
AREGAmphiregulin. (274 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMPERBMP binding endothelial regulator. (686 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (379 aa)
C6orf89Chromosome 6 open reading frame 89. (356 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
YAP1Yes associated protein 1. (506 aa)
TGFATransforming growth factor alpha. (166 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (368 aa)
CCN3Cellular communication network factor 3. (366 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
NOX5NADPH oxidase 5. (737 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SEMA5ASemaphorin 5A. (1074 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
XBP1BZIP domain-containing protein. (380 aa)
HSF4Heat shock transcription factor 4. (505 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1250 aa)
SIDT2SID1 transmembrane family member 2. (860 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
IL6Uncharacterized protein. (214 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
RUNX2RUNX family transcription factor 2. (611 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
IRS2Insulin receptor substrate 2. (1316 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (294 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (401 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1548 aa)
TBX2T-box transcription factor 2. (704 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
NF1Neurofibromin 1. (2839 aa)
FLCNFolliculin. (680 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
PTCH1Patched 1. (1452 aa)
IFT74Intraflagellar transport 74. (562 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
RB1RB transcriptional corepressor 1. (889 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
IFT52Intraflagellar transport 52. (437 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
FERMT1Fermitin family member 1. (663 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
BCL2L1BCL2 like 1. (233 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
NKX2-8NK2 homeobox 8. (239 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
EREGEpiregulin. (169 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HMX2H6 family homeobox 2. (273 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
MKI67Marker of proliferation Ki-67. (3249 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FOXE3Forkhead box E3. (318 aa)
NOTCH1Notch receptor 1. (2541 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1315 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
IFT80Intraflagellar transport 80. (777 aa)
IFT57Intraflagellar transport 57. (429 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
COL8A1Collagen type VIII alpha 1 chain. (746 aa)
NKX2-5NK2 homeobox 5. (324 aa)
CD34CD34 molecule. (385 aa)
LOC101003421BZIP domain-containing protein. (371 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
IRF6Interferon regulatory factor 6. (467 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
NKX3-1NK3 homeobox 1. (232 aa)
LOC101022119Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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