STRINGSTRING
HMOX1 HMOX1 MYDGF MYDGF ZNF304 ZNF304 TGFBR1 TGFBR1 PTN PTN IL18 IL18 DLX6 DLX6 JCAD JCAD BTK BTK JUND JUND EGR3 EGR3 AREG AREG APELA APELA BMPR1A BMPR1A PGF PGF BMP2 BMP2 PRKD1 PRKD1 IGF1 IGF1 CYBA CYBA STAT3 STAT3 TP63 TP63 ERBB2 ERBB2 ACVRL1 ACVRL1 FLT4 FLT4 YAP1 YAP1 TGFA TGFA BMP5 BMP5 ENSPANP00000035911 ENSPANP00000035911 ITGB3 ITGB3 EMC10 EMC10 OSR2 OSR2 NR4A3 NR4A3 PRKD2 PRKD2 WDR48 WDR48 LAMC1 LAMC1 STXBP4 STXBP4 SEMA5A SEMA5A C5AR1 C5AR1 HPN HPN TCF7L2 TCF7L2 GRN GRN KDM5B KDM5B XBP1 XBP1 HSF4 HSF4 HIF1A HIF1A STAT5A STAT5A AGTR1 AGTR1 ENSPANP00000024775 ENSPANP00000024775 FGF9 FGF9 GHRL GHRL SRSF6 SRSF6 FGFR2 FGFR2 GDF2 GDF2 RUNX2 RUNX2 IRS2 IRS2 CCR3 CCR3 PAX2 PAX2 MED1 MED1 SIRT1 SIRT1 NODAL NODAL CXCL12 CXCL12 NRP1 NRP1 NF1 NF1 TNFSF12 TNFSF12 TEK TEK B4GALT1 B4GALT1 ARG1 ARG1 FGF2 FGF2 AGAP2 AGAP2 REG3G REG3G REG3A REG3A HYAL1 HYAL1 MMP12 MMP12 PPP1R16B PPP1R16B PLCG1 PLCG1 TGM1 TGM1 ZNF580 ZNF580 SHH SHH BMP4 BMP4 ID1 ID1 SMO SMO SOX9 SOX9 HMX2 HMX2 HTRA1 HTRA1 PRKCA PRKCA RPTOR RPTOR ODAM ODAM FOXE3 FOXE3 NOTCH1 NOTCH1 CCL24 CCL24 MST1 MST1 HTR2B HTR2B TNFAIP3 TNFAIP3 IHH IHH PIK3CD PIK3CD WNT3A WNT3A KDR KDR VASH2 VASH2 MAP2K5 MAP2K5 FGF7 FGF7 ZBED9 ZBED9 BMP6 BMP6 RREB1 RREB1 PDGFB PDGFB AKT1 AKT1 PKHD1 PKHD1 ADAM17 ADAM17 VEGFA VEGFA NOD2 NOD2 CDH3 CDH3 CCL26 CCL26 ATP7A ATP7A NRAS NRAS SIRT6 SIRT6 RESP18 RESP18 VEGFB VEGFB GHSR GHSR JAML JAML GPBAR1 GPBAR1 NKX2-5 NKX2-5 SPINK1 SPINK1 LOC101003421 LOC101003421 SP1 SP1 EYA1 EYA1 VEGFC VEGFC EGF EGF LOC101022119 LOC101022119 LRG1 LRG1 HLX HLX FZD7 FZD7 MYC MYC FGF1 FGF1 NRP2 NRP2 TACR1 TACR1 CLDN1 CLDN1 HAS2 HAS2 IQGAP3 IQGAP3 GATA2 GATA2 AGGF1 AGGF1 LACRT LACRT WNT2 WNT2 MTA3 MTA3 ITGA4 ITGA4 AR AR VEGFD VEGFD RTN4 RTN4 SCN5A SCN5A EPGN EPGN WNT7A WNT7A IL10 IL10 SAAL1 SAAL1 BMPR2 BMPR2 WNT5A WNT5A ZNF703 ZNF703 CTNNB1 CTNNB1 PTPRN PTPRN OSR1 OSR1 NOTCH2 NOTCH2 NRARP NRARP TGFB1 TGFB1 ESRP2 ESRP2 DLX5 DLX5 PLXNB3 PLXNB3 EGFR EGFR IGF2 IGF2 VIP VIP ECM1 ECM1 ST8SIA1 ST8SIA1 PDPK1 PDPK1 FGFR1 FGFR1 NKX2-6 NKX2-6 AKT3 AKT3 SFRP1 SFRP1 NOG NOG PDX1 PDX1 ARNT ARNT CRNN CRNN TBX1 TBX1 THBS4 THBS4 ENSPANP00000001773 ENSPANP00000001773 PROK1 PROK1 PROX1 PROX1 MDK MDK NR4A1 NR4A1 HRAS HRAS APLNR APLNR FGF10 FGF10 F3 F3 BAD BAD ENSPANP00000000206 ENSPANP00000000206 CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMOX1Heme oxygenase 1. (288 aa)
MYDGFMyeloid derived growth factor. (190 aa)
ZNF304Zinc finger protein 304. (707 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PTNPleiotrophin. (172 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
DLX6Distal-less homeobox 6. (165 aa)
JCADJunctional cadherin 5 associated. (1356 aa)
BTKTyrosine-protein kinase. (659 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (309 aa)
EGR3Early growth response 3. (387 aa)
AREGAmphiregulin. (274 aa)
APELAApelin receptor early endogenous ligand. (55 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (184 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
IGF1Insulin like growth factor 1. (208 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
YAP1Yes associated protein 1. (506 aa)
TGFATransforming growth factor alpha. (166 aa)
BMP5Bone morphogenetic protein 5. (471 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
EMC10ER membrane protein complex subunit 10. (255 aa)
OSR2Odd-skipped related transciption factor 2. (401 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (888 aa)
WDR48WD repeat domain 48. (679 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
SEMA5ASemaphorin 5A. (1074 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
HPNHepsin; Belongs to the peptidase S1 family. (421 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
GRNGranulin precursor. (613 aa)
KDM5BLysine demethylase 5B. (1580 aa)
XBP1BZIP domain-containing protein. (380 aa)
HSF4Heat shock transcription factor 4. (505 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (832 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GHRLGhrelin and obestatin prepropeptide. (133 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
GDF2Growth differentiation factor 2. (429 aa)
RUNX2RUNX family transcription factor 2. (611 aa)
IRS2Insulin receptor substrate 2. (1316 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PAX2Paired box 2. (436 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1548 aa)
SIRT1Sirtuin 1. (743 aa)
NODALNodal growth differentiation factor. (330 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NF1Neurofibromin 1. (2839 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
ARG1Arginase. (322 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
REG3GRegenerating family member 3 gamma. (175 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
HYAL1Hyaluronidase. (435 aa)
MMP12Matrix metallopeptidase 12. (426 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
TGM1Transglutaminase 1. (818 aa)
ZNF580Zinc finger protein 580. (172 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (163 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HMX2H6 family homeobox 2. (273 aa)
HTRA1HtrA serine peptidase 1. (524 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
FOXE3Forkhead box E3. (318 aa)
NOTCH1Notch receptor 1. (2541 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1315 aa)
VASH2Vasohibin 2. (355 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ZBED9Zinc finger BED-type containing 9. (1325 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4072 aa)
ADAM17ADAM metallopeptidase domain 17. (1005 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1117 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
CCL26C-C motif chemokine. (94 aa)
ATP7AATPase copper transporting alpha. (1487 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SIRT6Sirtuin 6. (355 aa)
RESP18Regulated endocrine specific protein 18. (228 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
JAMLJunction adhesion molecule like. (394 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
NKX2-5NK2 homeobox 5. (324 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
LOC101003421BZIP domain-containing protein. (371 aa)
SP1Sp1 transcription factor. (803 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
LOC101022119Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (383 aa)
HLXH2.0 like homeobox. (494 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
HAS2Hyaluronan synthase 2. (552 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
GATA2GATA binding protein 2. (480 aa)
AGGF1Uncharacterized protein. (710 aa)
LACRTLacritin. (137 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1017 aa)
ARAndrogen receptor. (896 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
RTN4Reticulon. (1194 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
EPGNEpithelial mitogen. (154 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
IL10Interleukin 10. (178 aa)
SAAL1Serum amyloid A like 1. (473 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ZNF703Zinc finger protein 703. (591 aa)
CTNNB1Catenin beta 1. (781 aa)
PTPRNUncharacterized protein. (979 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
NOTCH2Notch receptor 2. (2603 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ESRP2Epithelial splicing regulatory protein 2. (725 aa)
DLX5Distal-less homeobox 5. (289 aa)
PLXNB3Plexin B3. (1909 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IGF2IlGF domain-containing protein. (245 aa)
VIPVasoactive intestinal peptide. (170 aa)
ECM1Extracellular matrix protein 1. (567 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
NKX2-6NK2 homeobox 6. (301 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
CRNNCornulin. (495 aa)
TBX1T-box transcription factor 1. (491 aa)
THBS4Thrombospondin 4. (961 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PROK1Prokineticin 1. (105 aa)
PROX1Prospero homeobox 1. (737 aa)
MDKMidkine. (161 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
HRASUncharacterized protein. (189 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
F3Coagulation factor III, tissue factor. (296 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSPANP00000000206Nucleoside diphosphate kinase. (169 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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