STRINGSTRING
MLST8 MLST8 ENSPANP00000000066 ENSPANP00000000066 PRNP PRNP CD74 CD74 FGF10 FGF10 GDNF GDNF PTK2B PTK2B TSLP TSLP IL5 IL5 IL3 IL3 IFNG IFNG THBS4 THBS4 PAK2 PAK2 NCF1 NCF1 HGF HGF CLEC6A CLEC6A FBXW7 FBXW7 ERBB4 ERBB4 SH2D1B SH2D1B IL2 IL2 CSF2 CSF2 KITLG KITLG IL12B IL12B EFNA5 EFNA5 NTF3 NTF3 IGF2 IGF2 CNTN1 CNTN1 EGFR EGFR EPO EPO STAP1 STAP1 GRM5 GRM5 IL6R IL6R TGFB1 TGFB1 LYN LYN BANK1 BANK1 IL24 IL24 YES1 YES1 PARP14 PARP14 EPHA4 EPHA4 ALKAL1 ALKAL1 ARHGEF2 ARHGEF2 HBEGF HBEGF EPGN EPGN LOC101003793 LOC101003793 ANGPT1 ANGPT1 IL21 IL21 TNFSF18 TNFSF18 PTPN11 PTPN11 HPX HPX GATA1 GATA1 PIBF1 PIBF1 FBXW9 FBXW9 LACRT LACRT ITGA5 ITGA5 IL15 IL15 AGT AGT TNFRSF14 TNFRSF14 HTR2A HTR2A TNFRSF1A TNFRSF1A PLPP3 PLPP3 EGF EGF EFNA1 EFNA1 GAS6 GAS6 DGKQ DGKQ PTPRJ PTPRJ IL20 IL20 PLCG2 PLCG2 CSF1R CSF1R VEGFB VEGFB ENPP2 ENPP2 OSBP OSBP IL4 IL4 DLG3 DLG3 IL23A IL23A CTF1 CTF1 LOC101023739 LOC101023739 TREM2 TREM2 NOD2 NOD2 VEGFA VEGFA ARL2BP ARL2BP ADAM17 ADAM17 LIF LIF OSM OSM PDGFB PDGFB BMP6 BMP6 FGF7 FGF7 CSPG4 CSPG4 PTK6 PTK6 LRRK1 LRRK1 CASS4 CASS4 ADNP ADNP PTPN1 PTPN1 IL6ST IL6ST WNT3A WNT3A HAX1 HAX1 TDGF1 TDGF1 RIPK2 RIPK2 HDAC2 HDAC2 CD80 CD80 MTOR MTOR LTK LTK EHD4 EHD4 GFRA1 GFRA1 GHV GHV CSH1 CSH1 GH1 GH1 PECAM1 PECAM1 EREG EREG ANGPT4 ANGPT4 FYN FYN CD40 CD40 LILRA5 LILRA5 HCLS1 HCLS1 PARP9 PARP9 IL23R IL23R IL12A IL12A KIT KIT SEMA4D SEMA4D SYK SYK DLG4 DLG4 DVL2 DVL2 UNC119 UNC119 NRP1 NRP1 ERCC6 ERCC6 CSF3 CSF3 FGF8 FGF8 ACE ACE NEURL1 NEURL1 TNK2 TNK2 DOCK3 DOCK3 RELN RELN RICTOR RICTOR IL6 IL6 ACVR1 ACVR1 ALK ALK CD44 CD44 GHRL GHRL DOK7 DOK7 CLCF1 CLCF1 AFAP1L2 AFAP1L2 NEDD9 NEDD9 FGFR3 FGFR3 GPRC5B GPRC5B ISL1 ISL1 ADIPOQ ADIPOQ ENSPANP00000028630 ENSPANP00000028630 LOC100999056 LOC100999056 SRC SRC NRG1 NRG1 HES5 HES5 MIF MIF CRLF1 CRLF1 ADRA1A ADRA1A TNFRSF18 TNFRSF18 ENSPANP00000032554 ENSPANP00000032554 FLT3 FLT3 PTPRC PTPRC ABI1 ABI1 TP53 TP53 LRP8 LRP8 ENSPANP00000033846 ENSPANP00000033846 ABL1 ABL1 ITGB3 ITGB3 TGFA TGFA ERBB3 ERBB3 ENSPANP00000037400 ENSPANP00000037400 ALKAL2 ALKAL2 IGF1 IGF1 CD36 CD36 LRP4 LRP4 ENSPANP00000040053 ENSPANP00000040053 HSF1 HSF1 SRCIN1 SRCIN1 ENSPANP00000041355 ENSPANP00000041355 IL31RA IL31RA IL34 IL34 AREG AREG CD81 CD81 BTC BTC ENSPANP00000043346 ENSPANP00000043346 ENSPANP00000044589 ENSPANP00000044589 CD3E CD3E IL18 IL18 JAK2 JAK2 LOC110741552 LOC110741552
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSPANP00000000066ARL2_Bind_BART domain-containing protein. (148 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
CD74CD74 molecule. (294 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
THBS4Thrombospondin 4. (961 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
FBXW7F-box and WD repeat domain containing 7. (706 aa)
ERBB4Receptor protein-tyrosine kinase. (1224 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
CSF2Granulocyte-macrophage colony-stimulating factor (Predicted). (144 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
IGF2IlGF domain-containing protein. (245 aa)
CNTN1Contactin 1. (1018 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
IL6RInterleukin 6 receptor. (468 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LYNTyrosine-protein kinase. (512 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (786 aa)
IL24Interleukin 24. (207 aa)
YES1Tyrosine-protein kinase. (550 aa)
PARP14Poly [ADP-ribose] polymerase. (1800 aa)
EPHA4EPH receptor A4. (986 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EPGNEpithelial mitogen. (154 aa)
LOC101003793Uncharacterized protein. (357 aa)
ANGPT1Angiopoietin 1. (498 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TNFSF18TNF superfamily member 18. (199 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
GATA1GATA binding protein 1. (413 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
LACRTLacritin. (137 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (177 aa)
AGTAngiotensinogen; Belongs to the serpin family. (490 aa)
TNFRSF14TNF receptor superfamily member 14. (282 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (450 aa)
TNFRSF1ATNF receptor superfamily member 1A. (459 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
GAS6Growth arrest specific 6. (679 aa)
DGKQDiacylglycerol kinase. (945 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1317 aa)
IL20Interleukin 20. (176 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (982 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (801 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (867 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CTF1Cardiotrophin 1. (201 aa)
LOC101023739Uncharacterized protein. (202 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1117 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (163 aa)
ADAM17ADAM metallopeptidase domain 17. (1005 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
OSMOncostatin M. (252 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2317 aa)
PTK6Tyrosine-protein kinase. (451 aa)
LRRK1Leucine rich repeat kinase 1. (2016 aa)
CASS4Cas scaffold protein family member 4. (812 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (465 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
HAX1HCLS1 associated protein X-1. (287 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (549 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (503 aa)
CD80CD80 molecule. (288 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
GHVUncharacterized protein. (217 aa)
CSH1Uncharacterized protein. (228 aa)
GH1Uncharacterized protein. (202 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
EREGEpiregulin. (169 aa)
ANGPT4Angiopoietin 4. (503 aa)
FYNTyrosine-protein kinase. (537 aa)
CD40Uncharacterized protein. (262 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (818 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
SYKTyrosine-protein kinase. (635 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
UNC119Unc-119 lipid binding chaperone. (240 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1494 aa)
CSF3Colony stimulating factor 3. (207 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1025 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (1935 aa)
RELNReelin. (3464 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
IL6Uncharacterized protein. (214 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
GHRLGhrelin and obestatin prepropeptide. (133 aa)
DOK7Docking protein 7. (565 aa)
CLCF1Cardiotrophin like cytokine factor 1. (230 aa)
AFAP1L2Actin filament associated protein 1 like 2. (846 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
FGFR3Fibroblast growth factor receptor. (775 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
ISL1ISL LIM homeobox 1. (395 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
ENSPANP00000028630Uncharacterized protein. (441 aa)
LOC100999056Uncharacterized protein. (248 aa)
SRCTyrosine-protein kinase. (644 aa)
NRG1Neuregulin 1. (713 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
CRLF1Cytokine receptor like factor 1. (459 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
TNFRSF18TNF receptor superfamily member 18. (243 aa)
ENSPANP00000032554Uncharacterized protein. (304 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (995 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1313 aa)
ABI1Abl interactor 1. (508 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
LRP8LDL receptor related protein 8. (972 aa)
ENSPANP00000033846Uncharacterized protein. (542 aa)
ABL1Tyrosine-protein kinase. (1112 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TGFATransforming growth factor alpha. (166 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1350 aa)
ENSPANP00000037400Uncharacterized protein. (78 aa)
ALKAL2ALK and LTK ligand 2. (171 aa)
IGF1Insulin like growth factor 1. (208 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
LRP4LDL receptor related protein 4. (1906 aa)
ENSPANP00000040053Uncharacterized protein. (72 aa)
HSF1Heat shock transcription factor 1. (532 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1281 aa)
ENSPANP00000041355Uncharacterized protein. (489 aa)
IL31RAInterleukin 31 receptor A. (761 aa)
IL34Interleukin 34. (242 aa)
AREGAmphiregulin. (274 aa)
CD81Tetraspanin. (274 aa)
BTCBetacellulin. (178 aa)
ENSPANP00000043346Uncharacterized protein. (139 aa)
ENSPANP00000044589CFC domain-containing protein. (170 aa)
CD3ECD3e molecule. (198 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
LOC110741552Uncharacterized protein. (196 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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