(139 nodes) Regulation of B cell activation network (Papio anubis)

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proteins of unknown 3D structure

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Your Input:
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
	CD40	Uncharacterized protein. (262 aa)
	BLK	Tyrosine-protein kinase. (505 aa)
	ENSPANP00000017532	Ig-like domain-containing protein. (132 aa)
	EPHB2	EPH receptor B2. (1085 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	SHLD1	Shieldin complex subunit 1. (205 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (453 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	TNFAIP3	TNF alpha induced protein 3. (804 aa)
	CTLA4	CD152 protein. (223 aa)
	CD27	CD27 molecule. (260 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1188 aa)
	BCL6	BCL6 transcription repressor. (700 aa)
	ENSPANP00000013492	Ig-like domain-containing protein. (120 aa)
	NFAM1	NFAT activating protein with ITAM motif 1. (271 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (186 aa)
	IGHD	Immunoglobulin heavy constant delta. (383 aa)
	TNFRSF21	TNF receptor superfamily member 21. (655 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1117 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	CD19	CD19 molecule. (558 aa)
	PCID2	PCI domain-containing protein. (453 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	ENSPANP00000011803	Ig-like domain-containing protein. (148 aa)
	SLC15A4	Solute carrier family 15 member 4. (496 aa)
	IL27RA	Interleukin 27 receptor subunit alpha. (636 aa)
	TCF3	Transcription factor 3. (679 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	ENSPANP00000010471	Ig-like domain-containing protein. (148 aa)
	LOC101003421	BZIP domain-containing protein. (371 aa)
	KMT5C	Lysine methyltransferase 5C. (461 aa)
	EXOSC6	Exosome component 6. (272 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	ENSPANP00000008310	Ig-like domain-containing protein. (117 aa)
	THOC1	THO complex 1. (661 aa)
	TBC1D10C	TBC1 domain family member 10C. (446 aa)
	SASH3	SAM and SH3 domain containing 3. (379 aa)
	TFRC	Transferrin receptor. (759 aa)
	SLAMF8	SLAM family member 8. (285 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (521 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
	TNIP2	TNFAIP3 interacting protein 2. (429 aa)
	THEMIS2	Thymocyte selection associated family member 2. (644 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	HMGB3	Uncharacterized protein. (201 aa)
	MZB1	Marginal zone B and B1 cell specific protein. (188 aa)
	SLC39A10	Solute carrier family 39 member 10. (831 aa)
	IL10	Interleukin 10. (178 aa)
	PARP3	Poly [ADP-ribose] polymerase. (539 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (905 aa)
	PAXIP1	PAX interacting protein 1. (1072 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1133 aa)
	CHRNB2	Cholinergic receptor nicotinic beta 2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (487 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (786 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (492 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	APLF	Aprataxin and PNKP like factor. (511 aa)
	TNFRSF4	TNF receptor superfamily member 4. (277 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (369 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	MLH1	MutL homolog 1. (756 aa)
	RIF1	Replication timing regulatory factor 1. (2466 aa)
	NDFIP1	Nedd4 family interacting protein 1. (221 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	BCL2	BCL2 apoptosis regulator. (238 aa)
	CD74	CD74 molecule. (294 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (144 aa)
	ENSPANP00000044875	Uncharacterized protein. (202 aa)
	CD28	IGv domain-containing protein. (234 aa)
	MORN5	MORN repeat containing 5. (161 aa)
	ENSPANP00000043887	Uncharacterized protein. (82 aa)
	ENSPANP00000043137	Ig-like domain-containing protein. (156 aa)
	TIRAP	TIR domain containing adaptor protein. (241 aa)
	CD81	Tetraspanin. (274 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1678 aa)
	STAT5B	Signal transducer and activator of transcription. (791 aa)
	SH3KBP1	SH3 domain containing kinase binding protein 1. (690 aa)
	IGLL1	Ig-like domain-containing protein. (197 aa)
	ENSPANP00000040254	Uncharacterized protein. (332 aa)
	FOXP3	Forkhead box P3. (456 aa)
	NFATC2	Nuclear factor of activated T cells 2. (925 aa)
	ENSPANP00000039722	Uncharacterized protein. (138 aa)
	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1. (441 aa)
	CD22	CD22 molecule. (823 aa)
	LOC103881441	Ig-like domain-containing protein. (132 aa)
	AKIRIN2	Akirin 2. (220 aa)
	PAWR	Pro-apoptotic WT1 regulator. (342 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1313 aa)
	FCRL3	Fc receptor like 3. (752 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (872 aa)
	IGHV7-81	Immunoglobulin heavy variable 7-81 (non-functional). (102 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (624 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	ADA	A_deaminase domain-containing protein. (449 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (836 aa)
	ENSPANP00000029568	Uncharacterized protein. (299 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	KMT5B	Lysine methyltransferase 5B. (885 aa)
	TP53BP1	Uncharacterized protein. (1932 aa)
	ENSPANP00000026514	FAM35_C domain-containing protein. (206 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (230 aa)
	SHLD2	FAM35_C domain-containing protein. (924 aa)
	PKN1	Protein kinase N1. (955 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1342 aa)
	LOC110742198	CCHC NOA-type domain-containing protein. (361 aa)
	ENSPANP00000023895	Uncharacterized protein. (191 aa)
	IL6	Uncharacterized protein. (214 aa)
	ENSPANP00000022562	Ig-like domain-containing protein. (108 aa)
	CDKN2B	Uncharacterized protein. (173 aa)
	IL4I1	Amine oxidase. (589 aa)
	IRS2	Insulin receptor substrate 2. (1316 aa)
	ENSPANP00000021653	Ig-like domain-containing protein. (170 aa)
	IKZF3	IKAROS family zinc finger 3. (509 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	ATAD5	ATPase family AAA domain containing 5. (1834 aa)
	ENSPANP00000019901	Uncharacterized protein. (195 aa)
	TNFRSF13B	TNF receptor superfamily member 13B. (269 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	ENSPANP00000019082	Uncharacterized protein. (200 aa)
	EXOSC3	Exosome component 3. (275 aa)
	CD320	CD320 molecule. (264 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	CD38	CD38 molecule. (301 aa)
	BST1	Bone marrow stromal cell antigen 1. (315 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (224 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	IL2	ENSPANP00000030617	ENSPANP00000003021	A_deaminase domain-containing protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.589
APLF	PARP3	ENSPANP00000003796	ENSPANP00000005317	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase.	0.833
ATAD5	ATM	ENSPANP00000019983	ENSPANP00000010521	ATPase family AAA domain containing 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.634
ATAD5	MAD2L2	ENSPANP00000019983	ENSPANP00000017976	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.605
ATAD5	MSH2	ENSPANP00000019983	ENSPANP00000005090	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.417
ATAD5	NSD2	ENSPANP00000019983	ENSPANP00000024239	ATPase family AAA domain containing 5.	Nuclear receptor binding SET domain protein 2.	0.569
ATM	ATAD5	ENSPANP00000010521	ENSPANP00000019983	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain containing 5.	0.634
ATM	BCL2	ENSPANP00000010521	ENSPANP00000001764	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.401
ATM	CDKN2B	ENSPANP00000010521	ENSPANP00000022281	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.400
ATM	ENSPANP00000039722	ENSPANP00000010521	ENSPANP00000039722	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.912
ATM	MLH1	ENSPANP00000010521	ENSPANP00000003232	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1.	0.853
ATM	MSH2	ENSPANP00000010521	ENSPANP00000005090	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.779
ATM	NSD2	ENSPANP00000010521	ENSPANP00000024239	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear receptor binding SET domain protein 2.	0.604
ATM	PAXIP1	ENSPANP00000010521	ENSPANP00000004882	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.912
ATM	PTEN	ENSPANP00000010521	ENSPANP00000020539	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.539
ATM	RIF1	ENSPANP00000010521	ENSPANP00000017924	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.866
ATM	TP53BP1	ENSPANP00000010521	ENSPANP00000027838	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.978
BAD	BCL2	ENSPANP00000000351	ENSPANP00000001764	BCL2 associated agonist of cell death.	BCL2 apoptosis regulator.	0.990
BANK1	CD19	ENSPANP00000004493	ENSPANP00000012458	B cell scaffold protein with ankyrin repeats 1.	CD19 molecule.	0.667
BCL2	ATM	ENSPANP00000001764	ENSPANP00000010521	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.401

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