node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | BRAF | ENSPANP00000003847 | ENSPANP00000018714 | A-Raf proto-oncogene, serine/threonine kinase. | B-Raf proto-oncogene, serine/threonine kinase. | 0.988 |
ARAF | PRKCA | ENSPANP00000003847 | ENSPANP00000016500 | A-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.899 |
ARAF | PRKCB | ENSPANP00000003847 | ENSPANP00000044126 | A-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.899 |
ARAF | PRKCD | ENSPANP00000003847 | ENSPANP00000011878 | A-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.783 |
ARAF | PRKCH | ENSPANP00000003847 | ENSPANP00000017059 | A-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.772 |
ARAF | PRKCQ | ENSPANP00000003847 | ENSPANP00000039583 | A-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C. | 0.765 |
ARAF | RAF1 | ENSPANP00000003847 | ENSPANP00000042344 | A-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.965 |
BRAF | ARAF | ENSPANP00000018714 | ENSPANP00000003847 | B-Raf proto-oncogene, serine/threonine kinase. | A-Raf proto-oncogene, serine/threonine kinase. | 0.988 |
BRAF | PRKCA | ENSPANP00000018714 | ENSPANP00000016500 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.903 |
BRAF | PRKCB | ENSPANP00000018714 | ENSPANP00000044126 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.902 |
BRAF | PRKCD | ENSPANP00000018714 | ENSPANP00000011878 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.765 |
BRAF | PRKCH | ENSPANP00000018714 | ENSPANP00000017059 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.802 |
BRAF | PRKCQ | ENSPANP00000018714 | ENSPANP00000039583 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C. | 0.765 |
BRAF | RAF1 | ENSPANP00000018714 | ENSPANP00000042344 | B-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.987 |
PRKCA | ARAF | ENSPANP00000016500 | ENSPANP00000003847 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | A-Raf proto-oncogene, serine/threonine kinase. | 0.899 |
PRKCA | BRAF | ENSPANP00000016500 | ENSPANP00000018714 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | B-Raf proto-oncogene, serine/threonine kinase. | 0.903 |
PRKCA | PRKCB | ENSPANP00000016500 | ENSPANP00000044126 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.926 |
PRKCA | PRKCD | ENSPANP00000016500 | ENSPANP00000011878 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.918 |
PRKCA | PRKCH | ENSPANP00000016500 | ENSPANP00000017059 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.466 |
PRKCA | PRKCI | ENSPANP00000016500 | ENSPANP00000007659 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.500 |