(24 nodes) AAA ATPase, AAA+ lid domain network (Papio anubis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (800 aa)
	ENSPANP00000000964	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. (685 aa)
	SPATA5	Spermatogenesis associated 5. (892 aa)
	YME1L1	YME1 like 1 ATPase. (760 aa)
	NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase. (769 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (461 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	PSMC3	AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa)
	NVL	Nuclear VCP like. (856 aa)
	KATNAL1	Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule- severing activity in vitro (By similarity). Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. (504 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (532 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (614 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	PEX1	Peroxisomal biogenesis factor 1. (1283 aa)
	LOC101025855	AAA domain-containing protein; Belongs to the AAA ATPase family. (696 aa)
	PSMC6	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (538 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (498 aa)
	ATAD2	ATPase family AAA domain containing 2. (1380 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (799 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (808 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (409 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	LOC101025855	ENSPANP00000003307	ENSPANP00000015512	AFG3 like matrix AAA peptidase subunit 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.922
AFG3L2	SPG7	ENSPANP00000003307	ENSPANP00000018671	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.826
ATAD2	ENSPANP00000000964	ENSPANP00000005010	ENSPANP00000000964	ATPase family AAA domain containing 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.466
ATAD2	PSMC3	ENSPANP00000005010	ENSPANP00000008888	ATPase family AAA domain containing 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.466
ATAD2	PSMC4	ENSPANP00000005010	ENSPANP00000005613	ATPase family AAA domain containing 2.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.466
ATAD2	PSMC6	ENSPANP00000005010	ENSPANP00000016906	ATPase family AAA domain containing 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.466
ENSPANP00000000964	ATAD2	ENSPANP00000000964	ENSPANP00000005010	AAA domain-containing protein; Belongs to the AAA ATPase family.	ATPase family AAA domain containing 2.	0.466
ENSPANP00000000964	KATNA1	ENSPANP00000000964	ENSPANP00000017256	AAA domain-containing protein; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]	0.496
ENSPANP00000000964	KATNAL1	ENSPANP00000000964	ENSPANP00000009005	AAA domain-containing protein; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule- severing activity in vitro (By similarity). Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.	0.497
ENSPANP00000000964	KATNAL2	ENSPANP00000000964	ENSPANP00000018235	AAA domain-containing protein; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.854
ENSPANP00000000964	PSMC1	ENSPANP00000000964	ENSPANP00000047118	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.971
ENSPANP00000000964	PSMC2	ENSPANP00000000964	ENSPANP00000012148	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.968
ENSPANP00000000964	PSMC3	ENSPANP00000000964	ENSPANP00000008888	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.954
ENSPANP00000000964	PSMC4	ENSPANP00000000964	ENSPANP00000005613	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.981
ENSPANP00000000964	PSMC5	ENSPANP00000000964	ENSPANP00000020937	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.978
ENSPANP00000000964	SPATA5	ENSPANP00000000964	ENSPANP00000037574	AAA domain-containing protein; Belongs to the AAA ATPase family.	Spermatogenesis associated 5.	0.469
ENSPANP00000000964	SPATA5L1	ENSPANP00000000964	ENSPANP00000033939	AAA domain-containing protein; Belongs to the AAA ATPase family.	Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family.	0.469
ENSPANP00000000964	VCP	ENSPANP00000000964	ENSPANP00000019119	AAA domain-containing protein; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.542
KATNA1	ENSPANP00000000964	ENSPANP00000017256	ENSPANP00000000964	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.496
KATNA1	KATNAL1	ENSPANP00000017256	ENSPANP00000009005	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]	Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule- severing activity in vitro (By similarity). Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.	0.403

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