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AP2A1 AP2A1 PAK3 PAK3 ENSPANP00000029311 ENSPANP00000029311 SRC SRC ENSPANP00000029897 ENSPANP00000029897 ENSPANP00000030056 ENSPANP00000030056 ACTR3 ACTR3 ARPC1A ARPC1A ENSPANP00000032717 ENSPANP00000032717 ENSPANP00000032942 ENSPANP00000032942 VAV3 VAV3 ACTR2 ACTR2 MYH11 MYH11 ENSPANP00000034674 ENSPANP00000034674 EPHB3 EPHB3 ACTG1 ACTG1 AP2S1 AP2S1 ENSPANP00000035124 ENSPANP00000035124 ENSPANP00000035674 ENSPANP00000035674 MYH14 MYH14 ARPC4 ARPC4 ENSPANP00000036576 ENSPANP00000036576 ENSPANP00000036680 ENSPANP00000036680 ENSPANP00000036814 ENSPANP00000036814 ENSPANP00000037673 ENSPANP00000037673 ENSPANP00000037968 ENSPANP00000037968 EPHA5 EPHA5 CDC42 CDC42 TIAM1 TIAM1 AP2M1 AP2M1 ENSPANP00000038985 ENSPANP00000038985 EPHA10 EPHA10 ENSPANP00000039822 ENSPANP00000039822 RHOA RHOA ENSPANP00000040479 ENSPANP00000040479 GRIN1 GRIN1 GIT1 GIT1 EFNA2 EFNA2 CFL1 CFL1 EFNA4 EFNA4 ACTR3B ACTR3B PTK2 PTK2 LIMK1 LIMK1 PSEN1 PSEN1 NCSTN NCSTN LIMK2 LIMK2 FNDC3B FNDC3B EFNB2 EFNB2 ENSPANP00000044488 ENSPANP00000044488 ENSPANP00000045505 ENSPANP00000045505 ENSPANP00000046766 ENSPANP00000046766 ARPC5 ARPC5 ENSPANP00000005238 ENSPANP00000005238 YES1 YES1 MYL12A MYL12A EFNB1 EFNB1 CLTB CLTB LYN LYN SDCBP SDCBP EPHA2 EPHA2 EFNA5 EFNA5 EPHB1 EPHB1 EFNA3 EFNA3 ACTL8 ACTL8 LOC101024285 LOC101024285 PSEN2 PSEN2 MYL6 MYL6 ELSPBP1 ELSPBP1 AP2A2 AP2A2 EFNA1 EFNA1 APH1A APH1A EPHB4 EPHB4 ARHGEF28 ARHGEF28 PAK1 PAK1 ARPC3 ARPC3 ACTRT2 ACTRT2 ACTB ACTB MYL12B MYL12B ACTL7A ACTL7A ENSPANP00000010678 ENSPANP00000010678 EPHB6 EPHB6 ACTL7B ACTL7B ENSPANP00000011336 ENSPANP00000011336 SDC2 SDC2 EPHA7 EPHA7 NCK2 NCK2 ENSPANP00000012445 ENSPANP00000012445 MMP2 MMP2 ROCK2 ROCK2 ITSN1 ITSN1 PAK2 PAK2 EPHA3 EPHA3 EPHA8 EPHA8 KALRN KALRN EPHA4 EPHA4 ENSPANP00000001806 ENSPANP00000001806 ENSPANP00000001773 ENSPANP00000001773 HRAS HRAS RASA1 RASA1 FNDC3A FNDC3A ACTRT1 ACTRT1 MYH9 MYH9 ARPC5L ARPC5L CFL2 CFL2 ADAM10 ADAM10 APH1B APH1B FMN2 FMN2 ARPC1B ARPC1B NGEF NGEF FMN1 FMN1 CLTCL1 CLTCL1 MYL9 MYL9 SDCBP2 SDCBP2 DSTN DSTN FYN FYN GRIN2B GRIN2B EPHB2 EPHB2 MMP9 MMP9 EPHA1 EPHA1 DNM1 DNM1 CLTA CLTA EFNB3 EFNB3 MYH10 MYH10 AP2B1 AP2B1 CLTC CLTC ROCK1 ROCK1 ENSPANP00000021931 ENSPANP00000021931 ENSPANP00000022011 ENSPANP00000022011 ENSPANP00000022961 ENSPANP00000022961 VAV2 VAV2 ARHGEF7 ARHGEF7 ENSPANP00000024607 ENSPANP00000024607 ENSPANP00000025644 ENSPANP00000025644 ENSPANP00000025762 ENSPANP00000025762 ARPC2 ARPC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ENSPANP00000029311Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (130 aa)
SRCTyrosine-protein kinase. (644 aa)
ENSPANP00000029897Uncharacterized protein. (115 aa)
ENSPANP00000030056Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (384 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ENSPANP00000032717ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (138 aa)
ENSPANP00000032942Uncharacterized protein. (182 aa)
VAV3Vav guanine nucleotide exchange factor 3. (872 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1985 aa)
ENSPANP00000034674Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (169 aa)
EPHB3EPH receptor B3. (1008 aa)
ACTG1Actin gamma 1. (377 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ENSPANP00000035124Uncharacterized protein. (87 aa)
ENSPANP00000035674ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (158 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ARPC4Uncharacterized protein. (279 aa)
ENSPANP00000036576B2-adapt-app_C domain-containing protein. (224 aa)
ENSPANP00000036680PDZ domain-containing protein. (290 aa)
ENSPANP00000036814ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (209 aa)
ENSPANP00000037673WD_REPEATS_REGION domain-containing protein. (336 aa)
ENSPANP00000037968Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (325 aa)
EPHA5EPH receptor A5. (1038 aa)
CDC42Cell division cycle 42. (191 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1577 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
ENSPANP00000038985Uncharacterized protein; Belongs to the actin family. (362 aa)
EPHA10EPH receptor A10. (1017 aa)
ENSPANP00000039822ADF-H domain-containing protein. (135 aa)
RHOARas homolog family member A. (193 aa)
ENSPANP00000040479PDZ domain-containing protein. (263 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
GIT1GIT ArfGAP 1. (770 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (213 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (196 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (206 aa)
ACTR3BActin related protein 3B; Belongs to the actin family. (471 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
LIMK1LIM domain kinase 1. (677 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (452 aa)
NCSTNNicastrin. (721 aa)
LIMK2LIM domain kinase 2. (638 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
ENSPANP00000044488WH1 domain-containing protein. (90 aa)
ENSPANP00000045505Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (377 aa)
ENSPANP00000046766Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (153 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
ENSPANP00000005238Uncharacterized protein. (547 aa)
YES1Tyrosine-protein kinase. (550 aa)
MYL12AMyosin light chain 12A. (177 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
LYNTyrosine-protein kinase. (512 aa)
SDCBPSyndecan binding protein. (318 aa)
EPHA2EPH receptor A2. (976 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
EPHB1EPH receptor B1. (984 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LOC101024285Uncharacterized protein. (191 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
MYL6Uncharacterized protein. (218 aa)
ELSPBP1Epididymal sperm binding protein 1. (223 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (941 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
EPHB4EPH receptor B4. (987 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1729 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
ACTBActin beta. (379 aa)
MYL12BMyosin light chain 12B. (172 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ENSPANP00000010678Uncharacterized protein. (152 aa)
EPHB6EPH receptor B6. (1019 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
ENSPANP00000011336Uncharacterized protein; Belongs to the actin family. (347 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
EPHA7EPH receptor A7. (998 aa)
NCK2Cytoplasmic protein. (382 aa)
ENSPANP00000012445Uncharacterized protein; Belongs to the actin family. (380 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ITSN1Uncharacterized protein. (1720 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
EPHA3EPH receptor A3. (984 aa)
EPHA8EPH receptor A8. (1005 aa)
KALRNKalirin RhoGEF kinase. (2944 aa)
EPHA4EPH receptor A4. (986 aa)
ENSPANP00000001806PDZ domain-containing protein. (258 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
HRASUncharacterized protein. (189 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1962 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (159 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
FMN2Formin 2. (1580 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (376 aa)
NGEFNeuronal guanine nucleotide exchange factor. (712 aa)
FMN1Formin 1. (1421 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
MYL9Myosin light chain 9. (172 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (165 aa)
FYNTyrosine-protein kinase. (537 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
EPHB2EPH receptor B2. (1085 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
EPHA1EPH receptor A1. (976 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
AP2B1AP complex subunit beta. (951 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ENSPANP00000021931Uncharacterized protein. (175 aa)
ENSPANP00000022011Uncharacterized protein. (153 aa)
ENSPANP00000022961Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (147 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
ENSPANP00000024607Uncharacterized protein. (225 aa)
ENSPANP00000025644Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (161 aa)
ENSPANP00000025762Uncharacterized protein. (157 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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