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| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | LIN37 | Lin-37 DREAM MuvB core complex component. (234 aa) |
| | ENSPANP00000000964 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (545 aa) |
| | E2F2 | E2F transcription factor 2. (438 aa) |
| | E2F5 | E2F transcription factor 5. (346 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | TFDP2 | Transcription factor. (446 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (953 aa) |
| | SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (165 aa) |
| | ENSPANP00000002997 | Ubiquitin-like domain-containing protein. (127 aa) |
| | DYRK1B | Dual specificity tyrosine phosphorylation regulated kinase 1B. (689 aa) |
| | TESMIN | Testis expressed metallothionein like protein. (508 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | ENSPANP00000003354 | Protein kinase domain-containing protein. (555 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | LIN54 | Lin-54 DREAM MuvB core complex component. (749 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (455 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | LIN52 | Lin-52 DREAM MuvB core complex component. (116 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | ORC3 | Origin recognition complex subunit 3. (690 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | LOC101001699 | S-phase kinase-associated protein 1. (163 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (325 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (294 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (380 aa) |
| | WEE2 | Wee1-like protein kinase. (568 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | CABLES1 | Cdk5 and Abl enzyme substrate 1. (626 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1150 aa) |
| | LOC101005785 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC101022082 | Ubiquitin-like domain-containing protein. (128 aa) |
| | TYMS | Thymidylate synthetase. (313 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2264 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (433 aa) |
| | ENSPANP00000010444 | Transcription factor. (392 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | CDC25A | Cell division cycle 25A. (524 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | FNBP4 | Formin binding protein 4. (1004 aa) |
| | FBXO5 | F-box protein 5. (448 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | CCND3 | Cyclin D3 (Predicted); Belongs to the cyclin family. (292 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1140 aa) |
| | DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | E2F6 | E2F transcription factor 6. (281 aa) |
| | E2F4 | E2F transcription factor 4. (417 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (872 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | ENSPANP00000014333 | Uncharacterized protein. (253 aa) |
| | PTK6 | Tyrosine-protein kinase. (451 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | LOC101019194 | WRNPLPNID domain-containing protein. (954 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa) |
| | LOC100999046 | Replication protein A 14 kDa subunit. (121 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1108 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PPP2R3B | EF-hand domain-containing protein. (510 aa) |
| | TK1 | Thymidine kinase. (275 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa) |
| | E2F1 | E2F transcription factor 1. (423 aa) |
| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | MYBL2 | MYB proto-oncogene like 2. (700 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | RB1 | RB transcriptional corepressor 1. (889 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | ENSPANP00000018792 | WD_REPEATS_REGION domain-containing protein. (262 aa) |
| | PSMB7 | Proteasome subunit beta. (302 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (51 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (625 aa) |
| | ENSPANP00000019650 | Uncharacterized protein. (121 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (552 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1549 aa) |
| | PSME3 | Proteasome activator subunit 3. (267 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (409 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa) |
| | ENSPANP00000021840 | Uncharacterized protein. (395 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | ENSPANP00000022442 | WD_REPEATS_REGION domain-containing protein. (418 aa) |
| | ENSPANP00000022572 | ANK_REP_REGION domain-containing protein. (170 aa) |
| | LOC101024029 | Proteasome subunit alpha type. (255 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (315 aa) |
| | ENSPANP00000023129 | Uncharacterized protein. (92 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | ENSPANP00000023509 | Protein kinase domain-containing protein. (322 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | MNAT1 | MNAT1 component of CDK activating kinase. (274 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | LOC101018157 | Ubiquitin-like domain-containing protein. (140 aa) |
| | KIAA2012 | KIAA2012. (1179 aa) |
| | LIN9 | Lin-9 DREAM MuvB core complex component. (613 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa) |
| | ENSPANP00000026851 | Uncharacterized protein. (77 aa) |
| | ENSPANP00000027020 | Hist_deacetyl domain-containing protein. (267 aa) |
| | ENSPANP00000027602 | MPN domain-containing protein. (149 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | RPA2 | Replication protein A2. (356 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (470 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (325 aa) |
| | ENSPANP00000029162 | Uncharacterized protein; Belongs to the AAA ATPase family. (402 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (329 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (378 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | ENSPANP00000030504 | RPA_C domain-containing protein. (246 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (339 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (433 aa) |
| | ENSPANP00000032176 | Ubiquitin-like domain-containing protein. (129 aa) |
| | ENSPANP00000032423 | Protein kinase domain-containing protein. (297 aa) |
| | ENSPANP00000032731 | Uncharacterized protein. (401 aa) |
| | ENSPANP00000032775 | Uncharacterized protein. (75 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | KXD1 | Ubiquitin-like domain-containing protein. (232 aa) |
| | E2F3 | E2F transcription factor 3. (460 aa) |
| | ENSPANP00000033198 | Hist_deacetyl domain-containing protein. (225 aa) |
| | ENSPANP00000033301 | Uncharacterized protein. (315 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa) |
| | FNDC3A | Fibronectin type III domain containing 3A. (1198 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | CDC7 | Protein kinase domain-containing protein. (574 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (880 aa) |
| | ABL1 | Tyrosine-protein kinase. (1112 aa) |
| | ENSPANP00000034651 | CSN8_PSD8_EIF3K domain-containing protein. (249 aa) |
| | ENSPANP00000034891 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSPANP00000035119 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (68 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | ENSPANP00000035552 | Prot_ATP_ID_OB domain-containing protein. (166 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | ENSPANP00000036982 | AAA domain-containing protein. (402 aa) |
| | ENSPANP00000037027 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (244 aa) |
| | PSMA6 | Proteasome subunit alpha type. (224 aa) |
| | PSMD4 | VWFA domain-containing protein. (380 aa) |
| | ENSPANP00000037475 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa) |
| | POLA1 | DNA polymerase. (1478 aa) |
| | ENSPANP00000038204 | WD_REPEATS_REGION domain-containing protein. (388 aa) |
| | ENSPANP00000038653 | Ubiquitin-like domain-containing protein. (124 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | CREBZF | CREB/ATF bZIP transcription factor. (358 aa) |
| | MAX | MYC associated factor X. (160 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSPANP00000041596 | AAA domain-containing protein; Belongs to the AAA ATPase family. (416 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | ENSPANP00000042542 | Uncharacterized protein. (196 aa) |
| | ENSPANP00000042759 | AAA domain-containing protein; Belongs to the AAA ATPase family. (319 aa) |
| | SKP2 | S-phase kinase associated protein 2. (424 aa) |
| | ENSPANP00000043416 | Ubiquitin-like domain-containing protein. (145 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (391 aa) |
| | FNDC3B | Fibronectin type III domain containing 3B. (1206 aa) |
| | ENSPANP00000045264 | ANK_REP_REGION domain-containing protein. (116 aa) |
| | ENSPANP00000045643 | WD_REPEATS_REGION domain-containing protein. (371 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ENSPANP00000046336 | AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa) |
| | ENSPANP00000046574 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (452 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (461 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (877 aa) |
| | LOC101015970 | Proteasome endopeptidase complex. (221 aa) |
| | JAK2 | Tyrosine-protein kinase. (1133 aa) |
