STRINGSTRING
LOC100997899 LOC100997899 UBE2M UBE2M ENSPANP00000000234 ENSPANP00000000234 ENSPANP00000000563 ENSPANP00000000563 WWTR1 WWTR1 GREM2 GREM2 MEIS3 MEIS3 SMAD5 SMAD5 ITGB6 ITGB6 E2F5 E2F5 IRX2 IRX2 LTBP3 LTBP3 PCSK4 PCSK4 TFDP2 TFDP2 LTBP1 LTBP1 JUNB JUNB NOG NOG PPP1R15A PPP1R15A XPO1 XPO1 ENSPANP00000002997 ENSPANP00000002997 ENSPANP00000003030 ENSPANP00000003030 ACVR1C ACVR1C PARP1 PARP1 FST FST CBL CBL TGFB1 TGFB1 HDAC1 HDAC1 USP15 USP15 LTBP2 LTBP2 FOXH1 FOXH1 CDK8 CDK8 TGFB2 TGFB2 ITGB5 ITGB5 SMAD7 SMAD7 BMPR2 BMPR2 PRKCZ PRKCZ TGFBR2 TGFBR2 PARD6A PARD6A CCNT1 CCNT1 TFDP1 TFDP1 SMAD4 SMAD4 ZFYVE9 ZFYVE9 ITGAV ITGAV LOC101021827 LOC101021827 F11R F11R ATP1B4 ATP1B4 MYC MYC BMP10 BMP10 LOC101005785 LOC101005785 LTBP4 LTBP4 LOC101022082 LOC101022082 SP1 SP1 MEN1 MEN1 PPP1CA PPP1CA ENSPANP00000010383 ENSPANP00000010383 ENSPANP00000010444 ENSPANP00000010444 AMH AMH ARHGEF18 ARHGEF18 ENSPANP00000010918 ENSPANP00000010918 YBX1 YBX1 CGN CGN IRX4 IRX4 CHRDL1 CHRDL1 MAPK3 MAPK3 IRX3 IRX3 IRX5 IRX5 IRX6 IRX6 E2F4 E2F4 FURIN FURIN EP300 EP300 STUB1 STUB1 FBN1 FBN1 RNF111 RNF111 SMAD3 SMAD3 ENSPANP00000014333 ENSPANP00000014333 PMEPA1 PMEPA1 SKI SKI SKIL SKIL SMAD1 SMAD1 INHBA INHBA ACVR1B ACVR1B TGFB3 TGFB3 RBL1 RBL1 ACVR2A ACVR2A FKBP1A FKBP1A COL1A2 COL1A2 CCNT2 CCNT2 DRAP1 DRAP1 ZCCHC4 ZCCHC4 CCNQ CCNQ SMURF1 SMURF1 CER1 CER1 CDK9 CDK9 NCOR1 NCOR1 ITGA8 ITGA8 BAMBI BAMBI MTMR4 MTMR4 BMPR1B BMPR1B IRX1 IRX1 SERPINE1 SERPINE1 CCNK CCNK ZFYVE16 ZFYVE16 GDF2 GDF2 RPS27A RPS27A ACVR1 ACVR1 ENSPANP00000023051 ENSPANP00000023051 ENSPANP00000023129 ENSPANP00000023129 FSTL3 FSTL3 AMHR2 AMHR2 CHRDL2 CHRDL2 SNW1 SNW1 SMAD6 SMAD6 ENSPANP00000046574 ENSPANP00000046574 TGFBR1 TGFBR1 ENSPANP00000024649 ENSPANP00000024649 ENSPANP00000024775 ENSPANP00000024775 LOC101018157 LOC101018157 ACVR2B ACVR2B MAPK1 MAPK1 MKX MKX STAT1 STAT1 ENSPANP00000026759 ENSPANP00000026759 ENSPANP00000027020 ENSPANP00000027020 PARD3B PARD3B PARD3 PARD3 NCOR2 NCOR2 LDLRAD4 LDLRAD4 SMAD9 SMAD9 SMURF2 SMURF2 ENSPANP00000032176 ENSPANP00000032176 KXD1 KXD1 ITGB1 ITGB1 INHBB INHBB ENSPANP00000033198 ENSPANP00000033198 ENSPANP00000033301 ENSPANP00000033301 TGIF2 TGIF2 UBE2D1 UBE2D1 TGIF2LY TGIF2LY TGIF1 TGIF1 ENSPANP00000034457 ENSPANP00000034457 ENSPANP00000034891 ENSPANP00000034891 PPP1CB PPP1CB ITGB3 ITGB3 SMAD2 SMAD2 ACVRL1 ACVRL1 TRIM33 TRIM33 NEDD4L NEDD4L ENSPANP00000038653 ENSPANP00000038653 ENSPANP00000039052 ENSPANP00000039052 USP9X USP9X BMP2 BMP2 RHOA RHOA BMPR1A BMPR1A PPM1A PPM1A ITGB8 ITGB8 STRAP STRAP ENSPANP00000043416 ENSPANP00000043416 FSTL1 FSTL1 PPP1CC PPP1CC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100997899Uncharacterized protein; Belongs to the cyclin family. (287 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ENSPANP00000000234CSP domain-containing protein. (292 aa)
ENSPANP00000000563Uncharacterized protein; Belongs to the cyclin family. (291 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
GREM2Gremlin. (168 aa)
MEIS3Meis homeobox 3. (446 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
E2F5E2F transcription factor 5. (346 aa)
IRX2Iroquois homeobox 2. (455 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1301 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (742 aa)
TFDP2Transcription factor. (446 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1720 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (629 aa)
XPO1Exportin 1. (1071 aa)
ENSPANP00000002997Ubiquitin-like domain-containing protein. (127 aa)
ENSPANP00000003030PPM-type phosphatase domain-containing protein. (354 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
FSTFollistatin. (344 aa)
CBLCbl proto-oncogene. (918 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (455 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
FOXH1Forkhead box H1. (366 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
TFDP1Transcription factor. (410 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
LOC101021827Ubiquitin-like domain-containing protein. (81 aa)
F11RF11 receptor. (299 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
LOC101005785Ubiquitin-like domain-containing protein. (156 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1617 aa)
LOC101022082Ubiquitin-like domain-containing protein. (128 aa)
SP1Sp1 transcription factor. (803 aa)
MEN1Uncharacterized protein. (610 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ENSPANP00000010383Uncharacterized protein. (331 aa)
ENSPANP00000010444Transcription factor. (392 aa)
AMHAnti-Mullerian hormone. (560 aa)
ARHGEF18Uncharacterized protein. (1184 aa)
ENSPANP00000010918CSD_1 domain-containing protein. (289 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
CGNCingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family. (1203 aa)
IRX4Iroquois homeobox 4. (515 aa)
CHRDL1Chordin like 1. (458 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IRX3Iroquois homeobox 3. (500 aa)
IRX5Iroquois homeobox 5. (483 aa)
IRX6Iroquois homeobox 6. (446 aa)
E2F4E2F transcription factor 4. (417 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
EP300E1A binding protein p300. (2427 aa)
STUB1STIP1 homology and U-box containing protein 1. (305 aa)
FBN1Fibrillin 1. (2871 aa)
RNF111Ring finger protein 111. (985 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSPANP00000014333Uncharacterized protein. (253 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
SKISKI proto-oncogene. (700 aa)
SKILSKI like proto-oncogene. (684 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
INHBAInhibin subunit beta A. (426 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RBL1RB transcriptional corepressor like 1. (1108 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FKBP1APeptidylprolyl isomerase. (139 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
DRAP1DR1 associated protein 1. (205 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (513 aa)
CCNQCyclin Q; Belongs to the cyclin family. (248 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CER1Cerberus 1, DAN family BMP antagonist. (269 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IRX1Iroquois homeobox 1. (480 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
CCNKCyclin K; Belongs to the cyclin family. (580 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1530 aa)
GDF2Growth differentiation factor 2. (429 aa)
RPS27ARibosomal protein S27a. (156 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
ENSPANP00000023051Homeobox domain-containing protein. (266 aa)
ENSPANP00000023129Uncharacterized protein. (92 aa)
FSTL3Follistatin like 3. (265 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
CHRDL2Chordin like 2. (452 aa)
SNW1SNW domain containing 1. (571 aa)
SMAD6Mothers against decapentaplegic homolog. (481 aa)
ENSPANP00000046574Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (452 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
ENSPANP00000024649annotation not available (50 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
LOC101018157Ubiquitin-like domain-containing protein. (140 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MKXMohawk homeobox. (352 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
ENSPANP00000026759CYCLIN domain-containing protein; Belongs to the cyclin family. (202 aa)
ENSPANP00000027020Hist_deacetyl domain-containing protein. (267 aa)
PARD3BPar-3 family cell polarity regulator beta. (1204 aa)
PARD3Par-3 family cell polarity regulator. (1353 aa)
NCOR2Nuclear receptor corepressor 2. (2519 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
SMAD9Mothers against decapentaplegic homolog. (512 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (682 aa)
ENSPANP00000032176Ubiquitin-like domain-containing protein. (129 aa)
KXD1Ubiquitin-like domain-containing protein. (232 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
INHBBInhibin subunit beta B. (407 aa)
ENSPANP00000033198Hist_deacetyl domain-containing protein. (225 aa)
ENSPANP00000033301Uncharacterized protein. (315 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
TGIF2LYTGFB induced factor homeobox 2 like Y-linked. (177 aa)
TGIF1TGFB induced factor homeobox 1. (286 aa)
ENSPANP00000034457Ubiquitin-like domain-containing protein. (73 aa)
ENSPANP00000034891Ubiquitin-like domain-containing protein. (156 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (328 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
TRIM33Tripartite motif containing 33. (1151 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1259 aa)
ENSPANP00000038653Ubiquitin-like domain-containing protein. (124 aa)
ENSPANP00000039052CSD_1 domain-containing protein. (291 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2507 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
RHOARas homolog family member A. (193 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (824 aa)
STRAPSerine/threonine kinase receptor associated protein. (363 aa)
ENSPANP00000043416Ubiquitin-like domain-containing protein. (145 aa)
FSTL1Follistatin like 1. (308 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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