(84 nodes) RHOC GTPase cycle network (Papio anubis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C1QBP	Complement C1q binding protein. (169 aa)
	ENSPANP00000039675	Uncharacterized protein. (2037 aa)
	RHOA	Ras homolog family member A. (193 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1135 aa)
	ACBD5	Acyl-CoA binding domain containing 5. (542 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1247 aa)
	PKN3	Protein kinase N3. (891 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor 40. (1519 aa)
	TGM6	Transglutaminase 6. (706 aa)
	TGM3	TGc domain-containing protein. (698 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1613 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1083 aa)
	ANLN	Anillin actin binding protein. (1127 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1078 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1028 aa)
	ABCD3	ATP binding cassette subfamily D member 3. (659 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1696 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	PKN2	Protein kinase N2. (983 aa)
	FMNL2	Formin like 2. (1093 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1114 aa)
	RNFT2	Ring finger protein, transmembrane 2. (444 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (273 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (192 aa)
	DEPDC1B	DEP domain containing 1B. (535 aa)
	ARHGEF28	Rho guanine nucleotide exchange factor 28. (1729 aa)
	VANGL1	Vang-like protein. (524 aa)
	FMNL3	Formin like 3. (1028 aa)
	MYO9B	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2157 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1499 aa)
	MCAM	Melanoma cell adhesion molecule. (646 aa)
	ARHGEF25	Uncharacterized protein. (619 aa)
	STK10	Serine/threonine kinase 10. (968 aa)
	TFRC	Transferrin receptor. (759 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1632 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1550 aa)
	RTKN	Rhotekin. (563 aa)
	STARD13	StAR related lipid transfer domain containing 13. (1112 aa)
	ARHGAP1	Rho GTPase activating protein 1. (439 aa)
	ARHGAP18	Rho GTPase activating protein 18. (663 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2137 aa)
	LBR	Lamin B receptor. (615 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
	ERBIN	Erbb2 interacting protein. (1418 aa)
	VAMP3	Vesicle associated membrane protein 3. (100 aa)
	MACO1	Macoilin 1. (664 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	RHOC	Ras homolog family member C. (193 aa)
	DIAPH1	Diaphanous related formin 1. (1244 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1517 aa)
	STX5	Syntaxin 5; Belongs to the syntaxin family. (361 aa)
	LMAN1	Lectin, mannose binding 1. (510 aa)
	ARHGEF17	Rho guanine nucleotide exchange factor 17. (2068 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	ARHGAP26	Rho GTPase activating protein 26. (814 aa)
	STOM	Stomatin. (288 aa)
	ABR	ABR activator of RhoGEF and GTPase. (872 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1943 aa)
	RNFT1	Ring finger protein, transmembrane 1. (435 aa)
	RTKN2	Rhotekin 2. (609 aa)
	JUP	Junction plakoglobin. (745 aa)
	CAVIN1	Caveolae associated protein 1. (391 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1527 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
	PKN1	Protein kinase N1. (955 aa)
	ENSPANP00000026191	Rho-GAP domain-containing protein. (206 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1277 aa)
	IPO11	Importin 11. (1015 aa)
	OPHN1	Oligophrenin 1. (802 aa)
	SLK	STE20 like kinase. (1236 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1362 aa)
	BCAM	Basal cell adhesion molecule (Lutheran blood group). (659 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1502 aa)
	AKAP13	A-kinase anchoring protein 13. (2875 aa)
	ENSPANP00000031927	Uncharacterized protein. (161 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (998 aa)
	DIAPH3	Diaphanous related formin 3. (1193 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD3	ACBD5	ENSPANP00000014853	ENSPANP00000041086	ATP binding cassette subfamily D member 3.	Acyl-CoA binding domain containing 5.	0.618
ABCD3	ANLN	ENSPANP00000014853	ENSPANP00000015398	ATP binding cassette subfamily D member 3.	Anillin actin binding protein.	0.570
ABCD3	CIT	ENSPANP00000014853	ENSPANP00000023447	ATP binding cassette subfamily D member 3.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.521
ABCD3	FLOT1	ENSPANP00000014853	ENSPANP00000013963	ATP binding cassette subfamily D member 3.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.451
ABCD3	FLOT2	ENSPANP00000014853	ENSPANP00000046053	ATP binding cassette subfamily D member 3.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.451
ABCD3	RHOA	ENSPANP00000014853	ENSPANP00000039995	ATP binding cassette subfamily D member 3.	Ras homolog family member A.	0.502
ABCD3	RHOC	ENSPANP00000014853	ENSPANP00000000823	ATP binding cassette subfamily D member 3.	Ras homolog family member C.	0.502
ABCD3	STOM	ENSPANP00000014853	ENSPANP00000018919	ATP binding cassette subfamily D member 3.	Stomatin.	0.467
ABR	ARHGAP1	ENSPANP00000019469	ENSPANP00000004731	ABR activator of RhoGEF and GTPase.	Rho GTPase activating protein 1.	0.517
ABR	DAAM1	ENSPANP00000019469	ENSPANP00000017021	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 1.	0.436
ABR	DAAM2	ENSPANP00000019469	ENSPANP00000022149	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 2.	0.436
ABR	MYO9B	ENSPANP00000019469	ENSPANP00000008550	ABR activator of RhoGEF and GTPase.	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.661
ABR	RHOA	ENSPANP00000019469	ENSPANP00000039995	ABR activator of RhoGEF and GTPase.	Ras homolog family member A.	0.467
ABR	RHOC	ENSPANP00000019469	ENSPANP00000000823	ABR activator of RhoGEF and GTPase.	Ras homolog family member C.	0.467
ABR	TJP2	ENSPANP00000019469	ENSPANP00000041122	ABR activator of RhoGEF and GTPase.	Uncharacterized protein; Belongs to the MAGUK family.	0.426
ACBD5	ABCD3	ENSPANP00000041086	ENSPANP00000014853	Acyl-CoA binding domain containing 5.	ATP binding cassette subfamily D member 3.	0.618
ACBD5	ANLN	ENSPANP00000041086	ENSPANP00000015398	Acyl-CoA binding domain containing 5.	Anillin actin binding protein.	0.508
ACBD5	CIT	ENSPANP00000041086	ENSPANP00000023447	Acyl-CoA binding domain containing 5.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.458
ACBD5	MYO9B	ENSPANP00000041086	ENSPANP00000008550	Acyl-CoA binding domain containing 5.	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.458
ACBD5	RHOA	ENSPANP00000041086	ENSPANP00000039995	Acyl-CoA binding domain containing 5.	Ras homolog family member A.	0.449

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