STRINGSTRING
LOC103875536 LOC103875536 DERL3 DERL3 CALR CALR BCL2 BCL2 MANF MANF SOD2 SOD2 CASP12 CASP12 CAPN2 CAPN2 LOC103876580 LOC103876580 CALR3 CALR3 LOC101008777 LOC101008777 TNF TNF MT4 MT4 LOC101023741 LOC101023741 LOC101022918 LOC101022918 LOC103880461 LOC103880461 LOC101022211 LOC101022211 LOC101024326 LOC101024326 LOC101025026 LOC101025026 LOC100999208 LOC100999208 MT1X MT1X CBS CBS ATF4 ATF4 INSIG1 INSIG1 CYP2E1 CYP2E1 MTR MTR ATF6 ATF6 DDIT3 DDIT3 SIRT1 SIRT1 SCD SCD LOC101022996 LOC101022996 LOC101024682 LOC101024682 IL6 IL6 H3C13 H3C13 LOC101008579 LOC101008579 LOC101024099 LOC101024099 LOC101022109 LOC101022109 LOC101007521 LOC101007521 LOC101004536 LOC101004536 XBP1 XBP1 MT1F MT1F ENSPANP00000033975 ENSPANP00000033975 LOC103880462 LOC103880462 LOC101002132 LOC101002132 PPARG PPARG LOC100997529 LOC100997529 ENSPANP00000044002 ENSPANP00000044002
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103875536Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
CALRCalreticulin. (417 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (182 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (703 aa)
LOC103876580Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CALR3Calreticulin. (384 aa)
LOC101008777Histone H3; Belongs to the histone H3 family. (136 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
LOC101023741Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC101022918Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
LOC103880461Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC101022211Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (59 aa)
LOC101024326Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (72 aa)
LOC101025026Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
LOC100999208Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa)
MT1XMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (565 aa)
ATF4Activating transcription factor 4. (351 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
CYP2E1Uncharacterized protein; Belongs to the cytochrome P450 family. (475 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1268 aa)
ATF6Activating transcription factor 6. (669 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
SIRT1Sirtuin 1. (743 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
LOC101022996Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101024682Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (71 aa)
IL6Uncharacterized protein. (214 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101008579Cytochrome c. (105 aa)
LOC101024099Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101022109Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101007521Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101004536Histone H3; Belongs to the histone H3 family. (136 aa)
XBP1BZIP domain-containing protein. (380 aa)
MT1FMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ENSPANP00000033975Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (60 aa)
LOC103880462Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC101002132Histone H3; Belongs to the histone H3 family. (136 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (470 aa)
LOC100997529Cytochrome c. (105 aa)
ENSPANP00000044002Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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