STRINGSTRING
PTPRZ1 PTPRZ1 IRF7 IRF7 CXCL10 CXCL10 ANKLE2 ANKLE2 WEE1 WEE1 TLR3 TLR3 CDK5 CDK5 CASP9 CASP9 MFN2 MFN2 CD4 CD4 UPF3A UPF3A LARP7 LARP7 CEP85 CEP85 TBK1 TBK1 IL10 IL10 CASP3 CASP3 AXL AXL CASP1 CASP1 RAG1 RAG1 CEP192 CEP192 OFD1 OFD1 GADD45A GADD45A GAS6 GAS6 USP18 USP18 CCNB1 CCNB1 CALR3 CALR3 TNF TNF IL4 IL4 MX2 MX2 RBM8A RBM8A DDX60 DDX60 SMG1 SMG1 SOX2 SOX2 IFIH1 IFIH1 NGDN NGDN TMEM41B TMEM41B NOS3 NOS3 LYAR LYAR DDX58 DDX58 IL33 IL33 SMG6 SMG6 NOS2 NOS2 UPF2 UPF2 CDK1 CDK1 IFIT2 IFIT2 IFIT3 IFIT3 CANX CANX MFF MFF CDKN2B CDKN2B JAK1 JAK1 IL6 IL6 CDKN1B CDKN1B STAT1 STAT1 IFI44 IFI44 IFIT5 IFIT5 ISG15 ISG15 MAGOH MAGOH DCX DCX UPF1 UPF1 CLN6 CLN6 STAT3 STAT3 IL37 IL37 GSDMD GSDMD IRF9 IRF9 RBFOX2 RBFOX2 IL18 IL18 STAT2 STAT2 CALR CALR BCL2 BCL2 IFNG IFNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2314 aa)
IRF7Interferon regulatory factor 7. (504 aa)
CXCL10C-X-C motif chemokine. (98 aa)
ANKLE2Ankyrin repeat and LEM domain containing 2. (939 aa)
WEE1Wee1-like protein kinase. (646 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (760 aa)
CD4CD4 molecule. (458 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (463 aa)
LARP7La ribonucleoprotein domain family member 7. (589 aa)
CEP85Uncharacterized protein. (801 aa)
TBK1TANK binding kinase 1. (729 aa)
IL10Interleukin 10. (178 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
CEP192Centrosomal protein 192. (2537 aa)
OFD1OFD1 centriole and centriolar satellite protein. (1013 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GAS6Growth arrest specific 6. (679 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (374 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
CALR3Calreticulin. (384 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
DDX60DExD/H-box helicase 60. (1712 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3659 aa)
SOX2SRY-box transcription factor 2. (319 aa)
IFIH1Interferon induced with helicase C domain 1. (1042 aa)
NGDNNeuroguidin. (315 aa)
TMEM41BTransmembrane protein 41B. (309 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
LYARLy1 antibody reactive. (340 aa)
DDX58DExD/H-box helicase 58. (925 aa)
IL33Interleukin 33. (270 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (471 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (487 aa)
CANXCalnexin. (670 aa)
MFFMitochondrial fission factor. (342 aa)
CDKN2BUncharacterized protein. (173 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IL6Uncharacterized protein. (214 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
IFI44Interferon induced protein 44. (438 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (482 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
DCXDoublecortin. (412 aa)
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
CLN6CLN6 transmembrane ER protein. (342 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL37Interleukin-1. (214 aa)
GSDMDGasdermin D. (532 aa)
IRF9Interferon regulatory factor 9. (392 aa)
RBFOX2RNA binding fox-1 homolog 2. (452 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
STAT2Signal transducer and activator of transcription. (855 aa)
CALRCalreticulin. (417 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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