STRINGSTRING
ERBB2 ERBB2 ERBB3 ERBB3 TGFA TGFA IGF1R IGF1R BAX BAX SHC1 SHC1 ENSPANP00000035568 ENSPANP00000035568 PIK3CB PIK3CB GAB1 GAB1 NRG1 NRG1 MET MET SRC SRC RPS6KB1 RPS6KB1 ENSPANP00000026850 ENSPANP00000026850 GSK3B GSK3B FGFR3 FGFR3 EIF4E EIF4E MAPK1 MAPK1 NRG2 NRG2 ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 EIF4E2 EIF4E2 FGFR2 FGFR2 IL6 IL6 ENSPANP00000022909 ENSPANP00000022909 JAK1 JAK1 MAP2K1 MAP2K1 PRKCG PRKCG PTEN PTEN PDGFA PDGFA NF1 NF1 SHC3 SHC3 LOC101000688 LOC101000688 BRAF BRAF FGF2 FGF2 ERAS ERAS BCL2L11 BCL2L11 EIF4EBP1 EIF4EBP1 PLCG1 PLCG1 SOS1 SOS1 BCL2L1 BCL2L1 SOS2 SOS2 PRKCA PRKCA GRB2 GRB2 MTOR MTOR PDGFC PDGFC PIK3CD PIK3CD KDR KDR SHC4 SHC4 CEP152 CEP152 PDGFB PDGFB AKT1 AKT1 VEGFA VEGFA MAPK3 MAPK3 EIF4E1B EIF4E1B NRAS NRAS PLCG2 PLCG2 GAS6 GAS6 ENSPANP00000009247 ENSPANP00000009247 LOC100997022 LOC100997022 EGF EGF TPTE2 TPTE2 RPS6KB2 RPS6KB2 PDGFRB PDGFRB ENSPANP00000007612 ENSPANP00000007612 PIK3R2 PIK3R2 PDGFRA PDGFRA AXL AXL PDGFD PDGFD PIK3CA PIK3CA FOXO3 FOXO3 CSDE1 CSDE1 BAD BAD HRAS HRAS SHC2 SHC2 PIK3R1 PIK3R1 BCL2 BCL2 ENSPANP00000001773 ENSPANP00000001773 PPP1R14B PPP1R14B PIK3R3 PIK3R3 HGF HGF AKT3 AKT3 ARAF ARAF EGFR EGFR IL6R IL6R STAT3 STAT3 IGF1 IGF1 MAP2K2 MAP2K2 TBCA TBCA RAF1 RAF1 PRKCB PRKCB AKT2 AKT2 KRAS KRAS JAK2 JAK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1350 aa)
TGFATransforming growth factor alpha. (166 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
SHC1SHC adaptor protein 1. (601 aa)
ENSPANP0000003556840S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (227 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
GAB1GRB2 associated binding protein 1. (790 aa)
NRG1Neuregulin 1. (713 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1404 aa)
SRCTyrosine-protein kinase. (644 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSPANP0000002685040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (203 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
FGFR3Fibroblast growth factor receptor. (775 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NRG2Neuregulin 2. (851 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
IL6Uncharacterized protein. (214 aa)
ENSPANP00000022909SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (111 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
NF1Neurofibromin 1. (2839 aa)
SHC3SHC adaptor protein 3. (598 aa)
LOC10100068840S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
ERASES cell expressed Ras. (233 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
BCL2L1BCL2 like 1. (233 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1315 aa)
SHC4SHC adaptor protein 4. (630 aa)
CEP152Centrosomal protein 152. (1706 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GAS6Growth arrest specific 6. (679 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
LOC10099702240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
TPTE2Uncharacterized protein. (550 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PIK3R2Uncharacterized protein. (721 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
PDGFDPlatelet derived growth factor D. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box O3. (672 aa)
CSDE1Cold shock domain containing E1. (844 aa)
BADBCL2 associated agonist of cell death. (168 aa)
HRASUncharacterized protein. (189 aa)
SHC2Uncharacterized protein. (567 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PPP1R14BUncharacterized protein. (207 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IL6RInterleukin 6 receptor. (468 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IGF1Insulin like growth factor 1. (208 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
RAF1Uncharacterized protein. (668 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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