(45 nodes) Mismatch repair network (Papio anubis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	YJU2	YJU2 splicing factor homolog. (323 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	POLD3	DNA polymerase delta 3, accessory subunit. (466 aa)
	SASS6	SAS-6 centriolar assembly protein. (657 aa)
	SSBP1	Single stranded DNA binding protein 1. (148 aa)
	MLH1	MutL homolog 1. (756 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (829 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (180 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	EXO1	Exonuclease 1. (846 aa)
	RPA3	Uncharacterized protein. (121 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (905 aa)
	CABP5	Calcium binding protein 5. (207 aa)
	MSH3	MutS homolog 3. (1218 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (931 aa)
	POLD4	Uncharacterized protein. (107 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
	POLD1	DNA polymerase. (1107 aa)
	RFC4	Replication factor C subunit 4. (345 aa)
	ISG20L2	Exonuclease domain-containing protein. (354 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	LOC100999046	Replication protein A 14 kDa subunit. (121 aa)
	PRKRIP1	PRKR interacting protein 1. (185 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (422 aa)
	MLH3	MutL homolog 3. (1456 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	GTF3C6	General transcription factor IIIC subunit 6. (213 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (625 aa)
	ENSPANP00000019650	Uncharacterized protein. (121 aa)
	ATAD5	ATPase family AAA domain containing 5. (1834 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
	FBH1	F-box DNA helicase 1. (1079 aa)
	ENSPANP00000023106	Exonuclease domain-containing protein. (331 aa)
	RPA2	Replication protein A2. (356 aa)
	LIG1	DNA ligase. (915 aa)
	ENSPANP00000030504	RPA_C domain-containing protein. (246 aa)
	RFC1	Replication factor C subunit 1. (1147 aa)
	ENSPANP00000037027	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (244 aa)
	MSH4	MutS homolog 4. (936 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (181 aa)
	RAD17	RAD17 checkpoint clamp loader component. (681 aa)

Your Current Organism:

Papio anubis

NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	ENSPANP00000037027	ENSPANP00000014403	ENSPANP00000037027	Apoptosis enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.620
AEN	FBH1	ENSPANP00000014403	ENSPANP00000021177	Apoptosis enhancing nuclease.	F-box DNA helicase 1.	0.543
AEN	PCNA	ENSPANP00000014403	ENSPANP00000017017	Apoptosis enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.620
ATAD5	ENSPANP00000019650	ENSPANP00000019983	ENSPANP00000019650	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.496
ATAD5	ENSPANP00000030504	ENSPANP00000019983	ENSPANP00000030504	ATPase family AAA domain containing 5.	RPA_C domain-containing protein.	0.589
ATAD5	ENSPANP00000037027	ENSPANP00000019983	ENSPANP00000037027	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.946
ATAD5	EXO1	ENSPANP00000019983	ENSPANP00000004652	ATPase family AAA domain containing 5.	Exonuclease 1.	0.954
ATAD5	FBH1	ENSPANP00000019983	ENSPANP00000021177	ATPase family AAA domain containing 5.	F-box DNA helicase 1.	0.719
ATAD5	LIG1	ENSPANP00000019983	ENSPANP00000029382	ATPase family AAA domain containing 5.	DNA ligase.	0.831
ATAD5	LOC100999046	ENSPANP00000019983	ENSPANP00000014753	ATPase family AAA domain containing 5.	Replication protein A 14 kDa subunit.	0.496
ATAD5	MEIOB	ENSPANP00000019983	ENSPANP00000042479	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.774
ATAD5	MSH2	ENSPANP00000019983	ENSPANP00000005090	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.417
ATAD5	MSH6	ENSPANP00000019983	ENSPANP00000007626	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.506
ATAD5	PCNA	ENSPANP00000019983	ENSPANP00000017017	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.946
ATAD5	POLD1	ENSPANP00000019983	ENSPANP00000008432	ATPase family AAA domain containing 5.	DNA polymerase.	0.791
ATAD5	POLD2	ENSPANP00000019983	ENSPANP00000018241	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.650
ATAD5	RAD17	ENSPANP00000019983	ENSPANP00000046855	ATPase family AAA domain containing 5.	RAD17 checkpoint clamp loader component.	0.946
ATAD5	RFC1	ENSPANP00000019983	ENSPANP00000031351	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.727
ATAD5	RFC2	ENSPANP00000019983	ENSPANP00000018672	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.974
ATAD5	RFC3	ENSPANP00000019983	ENSPANP00000004396	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.983

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