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| | MCFD2 | Multiple coagulation factor deficiency 2. (171 aa) |
| | PITHD1 | PITH domain containing 1. (211 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | GTF3C6 | General transcription factor IIIC subunit 6. (213 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (625 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSPANP00000045242 | Uncharacterized protein. (262 aa) |
| | RAD51B | RAD51 paralog B. (424 aa) |
| | ENSPANP00000042477 | Cor1 domain-containing protein. (193 aa) |
| | ENSPANP00000022324 | Uncharacterized protein. (241 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3430 aa) |
| | ENSPANP00000023354 | Uncharacterized protein. (290 aa) |
| | SEM1-2 | Uncharacterized protein. (89 aa) |
| | ENSPANP00000024608 | Uncharacterized protein. (245 aa) |
| | ENSPANP00000025250 | Reverse transcriptase domain-containing protein. (1275 aa) |
| | ENSPANP00000025532 | Reverse transcriptase domain-containing protein. (1275 aa) |
| | ENSPANP00000019650 | Uncharacterized protein. (121 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | RAD51C | RAD51 paralog C. (379 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1247 aa) |
| | DDX52 | DExD-box helicase 52. (599 aa) |
| | CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase. (423 aa) |
| | ENSPANP00000026704 | Uncharacterized protein. (260 aa) |
| | ENSPANP00000043976 | Uncharacterized protein. (257 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa) |
| | ENSPANP00000042609 | Reverse transcriptase domain-containing protein. (257 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa) |
| | ENSPANP00000027474 | Reverse transcriptase domain-containing protein. (264 aa) |
| | RPA2 | Replication protein A2. (356 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | ENSPANP00000028223 | Uncharacterized protein. (240 aa) |
| | ENSPANP00000029593 | Reverse transcriptase domain-containing protein. (1275 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ENSPANP00000030326 | Uncharacterized protein. (103 aa) |
| | ENSPANP00000030504 | RPA_C domain-containing protein. (246 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ENSPANP00000034808 | Uncharacterized protein. (75 aa) |
| | ENSPANP00000035320 | MPN domain-containing protein. (372 aa) |
| | ENSPANP00000037082 | Reverse transcriptase domain-containing protein. (233 aa) |
| | ENSPANP00000041386 | Uncharacterized protein. (252 aa) |
| | SUGP2 | SURP and G-patch domain containing 2. (1098 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | YJU2 | YJU2 splicing factor homolog. (323 aa) |
| | TM6SF2 | Transmembrane 6 superfamily member 2. (377 aa) |
| | N4BP2L2 | NEDD4 binding protein 2 like 2. (745 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (466 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (657 aa) |
| | HELB | DNA helicase B. (1087 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (750 aa) |
| | N4BP2 | NEDD4 binding protein 2. (1770 aa) |
| | FICD | FIC domain containing. (463 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | SYCP3 | Cor1 domain-containing protein. (236 aa) |
| | FAM9A | Family with sequence similarity 9 member A. (257 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1336 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1035 aa) |
| | PPIL3 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (180 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | N4BP2L1 | NEDD4 binding protein 2 like 1. (236 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1180 aa) |
| | SAP130 | Sin3A associated protein 130. (1083 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | SUGP1 | SURP and G-patch domain containing 1. (645 aa) |
| | UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (498 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | PTGDR2 | Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa) |
| | ATRX | ATRX chromatin remodeler. (2490 aa) |
| | FAM9C | Cor1 domain-containing protein. (157 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | ENSPANP00000010359 | G-patch domain-containing protein. (527 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | FAM9B | Family with sequence similarity 9 member B. (226 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | LURAP1 | Leucine rich adaptor protein 1. (239 aa) |
| | UNC93A | Unc-93 homolog A. (463 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | SLC4A1AP | Solute carrier family 4 member 1 adaptor protein. (774 aa) |
| | C12orf66 | Chromosome 12 open reading frame 66. (468 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1184 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | ENSPANP00000014057 | MPN domain-containing protein. (285 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | LOC100999046 | Replication protein A 14 kDa subunit. (121 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | MCPH1 | Microcephalin 1. (841 aa) |
| | PRKRIP1 | PRKR interacting protein 1. (185 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | ABRAXAS2 | Abraxas 2, BRISC complex subunit. (424 aa) |
