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| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (556 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1483 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (260 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa) |
| | CERS3 | Ceramide synthase 3. (385 aa) |
| | PTK6 | Tyrosine-protein kinase. (451 aa) |
| | SRMS | Tyrosine-protein kinase. (492 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (323 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (245 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | AADAC | Arylacetamide deacetylase. (399 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (977 aa) |
| | S1PR2 | Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | SPHK2 | Sphingosine kinase 2. (653 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (399 aa) |
| | S1PR3 | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | AADACL2 | Arylacetamide deacetylase like 2. (401 aa) |
| | ENSPANP00000009247 | Uncharacterized protein. (583 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1150 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (365 aa) |
| | TPTE2 | Uncharacterized protein. (550 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (459 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) |
| | S1PR4 | Sphingosine-1-phosphate receptor 4. (384 aa) |
| | CERS1 | TLC domain-containing protein. (352 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | PIK3R2 | Uncharacterized protein. (721 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (379 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | IFITM10 | Interferon induced transmembrane protein 10. (227 aa) |
| | GNAI1 | G protein subunit alpha i1. (422 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CERS5 | Ceramide synthase 5. (452 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (347 aa) |
| | ADAMTS19 | ADAM metallopeptidase with thrombospondin type 1 motif 19. (1245 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | GAB2 | GRB2 associated binding protein 2. (674 aa) |
| | ENSPANP00000001773 | Uncharacterized protein. (189 aa) |
| | BCL2 | BCL2 apoptosis regulator. (238 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (468 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (552 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (411 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (476 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | CERS2 | Ceramide synthase 2. (423 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (386 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1531 aa) |
| | ENSPANP00000041348 | Uncharacterized protein. (182 aa) |
| | ENSPANP00000040935 | Uncharacterized protein. (960 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (500 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | ENSPANP00000035911 | Protein kinase domain-containing protein. (137 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | NSMAF | Uncharacterized protein. (936 aa) |
| | ADAMTS17 | ADAM metallopeptidase with thrombospondin type 1 motif 17. (1106 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) |
| | ENSPANP00000027651 | Uncharacterized protein. (102 aa) |
| | ENSPANP00000027605 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (464 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (112 aa) |
| | KNG1 | Kininogen 1. (644 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (473 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | LOC101010611 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (514 aa) |
| | GNA12 | G protein subunit alpha 12. (381 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (413 aa) |
| | ASAH2 | Neutral ceramidase. (780 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | GNAQ | G protein subunit alpha q. (384 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | CERS4 | Ceramide synthase 4. (394 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | TMIGD3 | Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | GAB4 | GRB2 associated binding protein family member 4. (555 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1122 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | PPP2R3B | EF-hand domain-containing protein. (510 aa) |
