STRINGSTRING
SOX3 SOX3 TEAD2 TEAD2 TGFBR1 TGFBR1 PPP1CC PPP1CC MOB1B MOB1B LDAH LDAH TEAD1 TEAD1 STK3 STK3 AREG AREG BMPR1A BMPR1A TEAD3 TEAD3 ID2 ID2 BMP2 BMP2 APC APC ENSPANP00000038985 ENSPANP00000038985 WNT9A WNT9A WNT8B WNT8B DLG1 DLG1 MYO15B MYO15B SMAD2 SMAD2 YAP1 YAP1 TP53BP2 TP53BP2 BMP5 BMP5 PPP2R2A PPP2R2A ENSPANP00000035959 ENSPANP00000035959 PPP2R2C PPP2R2C AFP AFP PPP1CB PPP1CB ACTG1 ACTG1 LEF1 LEF1 YWHAG YWHAG CTNNA2 CTNNA2 DVL1 DVL1 ENSPANP00000030575 ENSPANP00000030575 ENSPANP00000030561 ENSPANP00000030561 YWHAQ YWHAQ ENSPANP00000030356 ENSPANP00000030356 PARD3 PARD3 TCF7L2 TCF7L2 WNT7B WNT7B TP73 TP73 GSK3B GSK3B DLG2 DLG2 ENSPANP00000025126 ENSPANP00000025126 ENSPANP00000024775 ENSPANP00000024775 BTRC BTRC MOB1A MOB1A ENSPANP00000022606 ENSPANP00000022606 SERPINE1 SERPINE1 ENSPANP00000021910 ENSPANP00000021910 PPP2R2B PPP2R2B BMPR1B BMPR1B TCF7 TCF7 WNT3 WNT3 WNT9B WNT9B FZD2 FZD2 CTNNA3 CTNNA3 DLG5 DLG5 FZD8 FZD8 LLGL1 LLGL1 MYO15A MYO15A DVL2 DVL2 DLG4 DLG4 YWHAE YWHAE FZD6 FZD6 CRB2 CRB2 CCN2 CCN2 ENSPANP00000018389 ENSPANP00000018389 WNT1 WNT1 BIRC3 BIRC3 PPP2R1B PPP2R1B AJUBA AJUBA YWHAB YWHAB PARD6G PARD6G LATS1 LATS1 MPP5 MPP5 BMP4 BMP4 ID1 ID1 FRMD6 FRMD6 SAV1 SAV1 GDF5 GDF5 SOX2 SOX2 GLI2 GLI2 AXIN2 AXIN2 CSNK1D CSNK1D BIRC5 BIRC5 LLGL2 LLGL2 PPP2R2D PPP2R2D TGFB3 TGFB3 WNT10A WNT10A SMAD1 SMAD1 GDF7 GDF7 YWHAZ YWHAZ WNT3A WNT3A PARD6B PARD6B BMP7 BMP7 SMAD3 SMAD3 BMP6 BMP6 AXIN1 AXIN1 LOC101001218 LOC101001218 YWHAH YWHAH NF2 NF2 LRRC1 LRRC1 ITGB2 ITGB2 NKD1 NKD1 CCND3 CCND3 ENSPANP00000012445 ENSPANP00000012445 APC2 APC2 CCND2 CCND2 DLG3 DLG3 FBXW11 FBXW11 ENSPANP00000011336 ENSPANP00000011336 ACTL7B ACTL7B WNT6 WNT6 AMH AMH AMOT AMOT ACTL7A ACTL7A FRMD1 FRMD1 ENSPANP00000010220 ENSPANP00000010220 PPP1CA PPP1CA PPP2R1A PPP2R1A FZD10 FZD10 FZD9 FZD9 ACTB ACTB ENSPANP00000009516 ENSPANP00000009516 ACTRT2 ACTRT2 FZD5 FZD5 LATS2 LATS2 WNT5B WNT5B WNT16 WNT16 TEAD4 TEAD4 FZD7 FZD7 MYC MYC FGF1 FGF1 PRKCI PRKCI WNT2B WNT2B PPP2CA PPP2CA WNT8A WNT8A WNT11 WNT11 WNT2 WNT2 SMAD4 SMAD4 FZD3 FZD3 PARD6A PARD6A DVL3 DVL3 PATJ PATJ TGFBR2 TGFBR2 LIMD1 LIMD1 RASSF1 RASSF1 SNAI2 SNAI2 WNT7A WNT7A WNT10B WNT10B PRKCZ PRKCZ BMPR2 BMPR2 WNT5A WNT5A SMAD7 SMAD7 CTNNB1 CTNNB1 TGFB2 TGFB2 NKD2 NKD2 TGFB1 TGFB1 GDF6 GDF6 FZD4 FZD4 WNT4 WNT4 BBC3 BBC3 WWC1 WWC1 RASSF6 RASSF6 PPP2CB PPP2CB TCF7L1 TCF7L1 SCRIB SCRIB ACTL8 ACTL8 CTNNA1 CTNNA1 CRB1 CRB1 CDH1 CDH1 BIRC2 BIRC2 BMP8B BMP8B WWTR1 WWTR1 ACTRT1 ACTRT1 SOX1 SOX1 CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX3SRY-box transcription factor 3. (440 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
MOB1BMOB kinase activator 1B. (221 aa)
LDAHLipid droplet associated hydrolase. (370 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
STK3Serine/threonine kinase 3. (534 aa)
AREGAmphiregulin. (274 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
ENSPANP00000038985Uncharacterized protein; Belongs to the actin family. (362 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
MYO15BMyosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3038 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
YAP1Yes associated protein 1. (506 aa)
TP53BP2Tumor protein p53 binding protein 2. (1160 aa)
BMP5Bone morphogenetic protein 5. (471 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
ENSPANP0000003595914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
AFPAlpha fetoprotein. (622 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (328 aa)
ACTG1Actin gamma 1. (377 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CTNNA2Catenin alpha 2. (953 aa)
DVL1Dishevelled segment polarity protein 1. (684 aa)
ENSPANP0000003057514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (218 aa)
ENSPANP00000030561Uncharacterized protein. (216 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (267 aa)
ENSPANP0000003035614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (227 aa)
PARD3Par-3 family cell polarity regulator. (1353 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
ENSPANP0000002512614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (209 aa)
ENSPANP00000024775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
MOB1AUncharacterized protein. (221 aa)
ENSPANP0000002260614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
ENSPANP00000021910Uncharacterized protein. (822 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TCF7Transcription factor 7. (480 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
CTNNA3Catenin alpha 3. (895 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (680 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3517 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CRB2Crumbs cell polarity complex component 2. (1290 aa)
CCN2Connective tissue growth factor (Predicted). (349 aa)
ENSPANP00000018389TGF_BETA_2 domain-containing protein. (391 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
AJUBAAjuba LIM protein. (538 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (163 aa)
FRMD6FERM domain containing 6. (614 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
GDF5Growth differentiation factor 5 (Predicted). (499 aa)
SOX2SRY-box transcription factor 2. (319 aa)
GLI2GLI family zinc finger 2. (1552 aa)
AXIN2Axin 2. (844 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
BIRC5Uncharacterized protein. (144 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SMAD1Mothers against decapentaplegic homolog. (498 aa)
GDF7Growth differentiation factor 7. (447 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (246 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
AXIN1Axin 1, isoform 1 (Predicted). (867 aa)
LOC101001218Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Predicted); Belongs to the 14-3-3 family. (246 aa)
NF2Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (595 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ITGB2Integrin beta. (919 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
CCND3Cyclin D3 (Predicted); Belongs to the cyclin family. (292 aa)
ENSPANP00000012445Uncharacterized protein; Belongs to the actin family. (380 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (867 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
ENSPANP00000011336Uncharacterized protein; Belongs to the actin family. (347 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
AMHAnti-Mullerian hormone. (560 aa)
AMOTAngiomotin. (1011 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
FRMD1FERM domain containing 1. (550 aa)
ENSPANP0000001022014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ACTBActin beta. (379 aa)
ENSPANP0000000951614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
PATJPATJ crumbs cell polarity complex component. (1802 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LIMD1LIM domains containing 1. (676 aa)
RASSF1Ras association domain family member 1. (344 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SMAD7Mothers against decapentaplegic homolog. (493 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (454 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF6Growth differentiation factor 6. (455 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BBC3BCL2 binding component 3. (261 aa)
WWC1WW and C2 domain containing 1. (1117 aa)
RASSF6Ras association domain family member 6. (369 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
SCRIBScribble planar cell polarity protein. (1661 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
CTNNA1Catenin alpha 1. (906 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
SOX1SRY-box transcription factor 1. (373 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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