STRINGSTRING
CBLB CBLB IL2 IL2 CSF2 CSF2 PDPK1 PDPK1 CD4 CD4 PDCD1 PDCD1 PIK3CA PIK3CA IL10 IL10 NFKBIB NFKBIB BCL10 BCL10 PPP3CC PPP3CC PAK1 PAK1 PIK3R2 PIK3R2 CD8A CD8A CDK4 CDK4 TRAC TRAC PAK4 PAK4 NFATC1 NFATC1 LCP2 LCP2 ENSPANP00000009247 ENSPANP00000009247 NFKB1 NFKB1 MAPK9 MAPK9 TNF TNF NRAS NRAS IL4 IL4 ICOS ICOS NCK2 NCK2 ZAP70 ZAP70 LAT LAT MAPK3 MAPK3 MAPK14 MAPK14 NFKBIE NFKBIE AKT1 AKT1 GRAP2 GRAP2 MAPK12 MAPK12 MAPK11 MAPK11 SRMS SRMS PTK6 PTK6 PIK3CD PIK3CD CTLA4 CTLA4 FOS FOS GRB2 GRB2 PAK6 PAK6 SOS2 SOS2 PAK5 PAK5 FYN FYN TEC TEC SOS1 SOS1 PLCG1 PLCG1 ERAS ERAS MAP3K8 MAP3K8 MAP3K14 MAP3K14 CHUK CHUK ENSPANP00000021931 ENSPANP00000021931 ENSPANP00000022011 ENSPANP00000022011 MAP2K1 MAP2K1 PPP3CB PPP3CB PPP3R1 PPP3R1 VAV2 VAV2 RASGRP1 RASGRP1 MAPK1 MAPK1 CD8B CD8B CARD11 CARD11 GSK3B GSK3B PAK3 PAK3 NFATC3 NFATC3 MAP3K7 MAP3K7 NFKBIA NFKBIA PTPN6 PTPN6 ENSPANP00000032942 ENSPANP00000032942 VAV3 VAV3 PTPRC PTPRC MAPK8 MAPK8 PIK3CB PIK3CB CD3D CD3D ENSPANP00000035911 ENSPANP00000035911 CD40LG CD40LG DLG1 DLG1 CDC42 CDC42 MAPK10 MAPK10 MAP2K2 MAP2K2 IKBKB IKBKB PRKCQ PRKCQ NFATC2 NFATC2 RHOA RHOA MAP2K7 MAP2K7 PPP3CA PPP3CA CD247 CD247 NCK1 NCK1 RAF1 RAF1 LCK LCK MAPK13 MAPK13 CD28 CD28 RELA RELA AKT2 AKT2 CD3E CD3E KRAS KRAS CSDE1 CSDE1 RHOC RHOC HRAS HRAS CD3G CD3G PIK3R1 PIK3R1 IL5 IL5 ENSPANP00000001773 ENSPANP00000001773 IFNG IFNG PAK2 PAK2 MALT1 MALT1 PIK3R3 PIK3R3 LOC101024285 LOC101024285 AKT3 AKT3 VAV1 VAV1 ITK ITK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLBCbl proto-oncogene B. (982 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
CSF2Granulocyte-macrophage colony-stimulating factor (Predicted). (144 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
CD4CD4 molecule. (458 aa)
PDCD1Programmed cell death 1. (288 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL10Interleukin 10. (178 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
BCL10BCL10 immune signaling adaptor. (311 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PIK3R2Uncharacterized protein. (721 aa)
CD8ACD8a molecule. (276 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TRACT cell receptor alpha constant. (110 aa)
PAK4Non-specific serine/threonine protein kinase. (597 aa)
NFATC1Nuclear factor of activated T cells 1. (930 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
ICOSInducible T cell costimulator. (199 aa)
NCK2Cytoplasmic protein. (382 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
LATLinker for activation of T cells. (270 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NFKBIENFKB inhibitor epsilon. (489 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SRMSTyrosine-protein kinase. (492 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CTLA4CD152 protein. (223 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
FYNTyrosine-protein kinase. (537 aa)
TECTyrosine-protein kinase. (630 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ERASES cell expressed Ras. (233 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (572 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSPANP00000021931Uncharacterized protein. (175 aa)
ENSPANP00000022011Uncharacterized protein. (153 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PPP3R1Uncharacterized protein. (189 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
RASGRP1RAS guanyl releasing protein 1. (842 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CD8BIg-like domain-containing protein. (243 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (624 aa)
ENSPANP00000032942Uncharacterized protein. (182 aa)
VAV3Vav guanine nucleotide exchange factor 3. (872 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1313 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CD3DCD3d molecule. (171 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
CDC42Cell division cycle 42. (191 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
PRKCQProtein kinase C. (753 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
RHOARas homolog family member A. (193 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (446 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CD247Uncharacterized protein. (165 aa)
NCK1NCK adaptor protein 1. (313 aa)
RAF1Uncharacterized protein. (668 aa)
LCKTyrosine-protein kinase. (545 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
CD28IGv domain-containing protein. (234 aa)
RELARELA proto-oncogene, NF-kB subunit. (476 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CD3ECD3e molecule. (198 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
RHOCRas homolog family member C. (193 aa)
HRASUncharacterized protein. (189 aa)
CD3GCD3g molecule. (181 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MALT1MALT1 paracaspase. (824 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
LOC101024285Uncharacterized protein. (191 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ITKTyrosine-protein kinase. (620 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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