STRINGSTRING
RHOC RHOC IRAK1 IRAK1 HRAS HRAS SHC2 SHC2 PIK3R1 PIK3R1 MAPKAPK2 MAPKAPK2 BCL2 BCL2 ENSPANP00000001773 ENSPANP00000001773 PPP1R14B PPP1R14B PSEN2 PSEN2 CSDE1 CSDE1 BAD BAD GCNA GCNA NGF NGF MATK MATK KRAS KRAS CAMK2B CAMK2B CAMK2D CAMK2D AKT2 AKT2 RELA RELA PVALEF PVALEF BDNF BDNF PSEN1 PSEN1 MAPK13 MAPK13 RAF1 RAF1 MAGED1 MAGED1 ENSPANP00000041355 ENSPANP00000041355 MAP2K7 MAP2K7 RPS6KA3 RPS6KA3 NGFR NGFR RHOA RHOA IKBKB IKBKB MAP2K2 MAP2K2 MAPK10 MAPK10 CDC42 CDC42 BAX BAX RAPGEF1 RAPGEF1 SHC1 SHC1 ENSPANP00000035959 ENSPANP00000035959 ENSPANP00000035911 ENSPANP00000035911 ARHGDIB ARHGDIB ARHGDIA ARHGDIA NTRK2 NTRK2 ABL1 ABL1 CALML6 CALML6 ENSPANP00000033846 ENSPANP00000033846 PIK3CB PIK3CB MAPK8 MAPK8 TP53 TP53 ENSPANP00000033457 ENSPANP00000033457 ENSPANP00000032942 ENSPANP00000032942 SH2B1 SH2B1 GAB1 GAB1 MAP3K3 MAP3K3 RPS6KA1 RPS6KA1 NFKBIA NFKBIA ENSPANP00000030371 ENSPANP00000030371 NTRK3 NTRK3 RPS6KA2 RPS6KA2 ENSPANP00000028630 ENSPANP00000028630 CALM2 CALM2 TP73 TP73 GSK3B GSK3B ENSPANP00000026453 ENSPANP00000026453 MAPK1 MAPK1 KIDINS220 KIDINS220 ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 ARSI ARSI SORT1 SORT1 MAP2K1 MAP2K1 ENSPANP00000022011 ENSPANP00000022011 ENSPANP00000021931 ENSPANP00000021931 ENSPANP00000021624 ENSPANP00000021624 ENSPANP00000021036 ENSPANP00000021036 CAMK2G CAMK2G MAPK7 MAPK7 CRK CRK YWHAE YWHAE SHC3 SHC3 BRAF BRAF ERAS ERAS PLCG1 PLCG1 SOS1 SOS1 SOS2 SOS2 GRB2 GRB2 CRKL CRKL RPS6KA5 RPS6KA5 CALM1 CALM1 SH2B2 SH2B2 MAP3K5 MAP3K5 RIPK2 RIPK2 PIK3CD PIK3CD IRAK3 IRAK3 CSK CSK CALML4 CALML4 MAP2K5 MAP2K5 SHC4 SHC4 CEP152 CEP152 MAPK11 MAPK11 MAPK12 MAPK12 ARHGDIG ARHGDIG ATF4 ATF4 AKT1 AKT1 NFKBIE NFKBIE MAPK14 MAPK14 MAPK3 MAPK3 CALM3 CALM3 PRKCD PRKCD NRAS NRAS MAPK9 MAPK9 NFKB1 NFKB1 MAP3K1 MAP3K1 ZFR ZFR PLCG2 PLCG2 CAMK4 CAMK4 ENSPANP00000009247 ENSPANP00000009247 ZFR2 ZFR2 RPS6KA6 RPS6KA6 CALML3 CALML3 FRS2 FRS2 IRAK4 IRAK4 PRDM4 PRDM4 IRAK2 IRAK2 ZNF274 ZNF274 ZSCAN1 ZSCAN1 ENSPANP00000007612 ENSPANP00000007612 PIK3R2 PIK3R2 PTPN11 PTPN11 CAMK2A CAMK2A SH2B3 SH2B3 RAC1 RAC1 NTF4 NTF4 FASLG FASLG NFKBIB NFKBIB RAP1B RAP1B PIK3CA PIK3CA FOXO3 FOXO3 TRAF6 TRAF6 NTF3 NTF3 PDPK1 PDPK1 NTRK1 NTRK1 AKT3 AKT3 LOC101024285 LOC101024285 BEX3 BEX3 PIK3R3 PIK3R3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOCRas homolog family member C. (193 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
HRASUncharacterized protein. (189 aa)
SHC2Uncharacterized protein. (567 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (373 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PPP1R14BUncharacterized protein. (207 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
CSDE1Cold shock domain containing E1. (844 aa)
BADBCL2 associated agonist of cell death. (168 aa)
GCNAGerm cell nuclear acidic peptidase. (668 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
MATKTyrosine-protein kinase. (591 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (476 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (452 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
RAF1Uncharacterized protein. (668 aa)
MAGED1MAGE family member D1. (834 aa)
ENSPANP00000041355Uncharacterized protein. (489 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (446 aa)
RPS6KA3Ribosomal protein S6 kinase. (768 aa)
NGFRNerve growth factor receptor. (429 aa)
RHOARas homolog family member A. (193 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CDC42Cell division cycle 42. (191 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
SHC1SHC adaptor protein 1. (601 aa)
ENSPANP0000003595914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (234 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ABL1Tyrosine-protein kinase. (1112 aa)
CALML6Calmodulin like 6. (181 aa)
ENSPANP00000033846Uncharacterized protein. (542 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
ENSPANP00000033457Uncharacterized protein; Belongs to the calmodulin family. (99 aa)
ENSPANP00000032942Uncharacterized protein. (182 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
GAB1GRB2 associated binding protein 1. (790 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (658 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ENSPANP00000030371Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
RPS6KA2Ribosomal protein S6 kinase. (741 aa)
ENSPANP00000028630Uncharacterized protein. (441 aa)
CALM2Calmodulin 2. (149 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSPANP00000026453Uncharacterized protein. (128 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
KIDINS220Kinase D interacting substrate 220. (1773 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
ARSIArylsulfatase family member I. (569 aa)
SORT1Sortilin. (864 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSPANP00000022011Uncharacterized protein. (153 aa)
ENSPANP00000021931Uncharacterized protein. (175 aa)
ENSPANP00000021624BZIP domain-containing protein. (322 aa)
ENSPANP00000021036NGF domain-containing protein; Belongs to the NGF-beta family. (197 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
SHC3SHC adaptor protein 3. (598 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
ERASES cell expressed Ras. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (896 aa)
CALM1Calmodulin 1. (149 aa)
SH2B2SH2B adaptor protein 2. (678 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CSKTyrosine-protein kinase. (450 aa)
CALML4Calmodulin like 4. (194 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
SHC4SHC adaptor protein 4. (630 aa)
CEP152Centrosomal protein 152. (1706 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ARHGDIGUncharacterized protein. (225 aa)
ATF4Activating transcription factor 4. (351 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFKBIENFKB inhibitor epsilon. (489 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
MAP3K1Uncharacterized protein. (1508 aa)
ZFRZinc finger RNA binding protein. (1061 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
ZFR2Zinc finger RNA binding protein 2. (932 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
ZNF274Zinc finger protein 274. (654 aa)
ZSCAN1Zinc finger and SCAN domain containing 1. (408 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PIK3R2Uncharacterized protein. (721 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
RAC1Rac family small GTPase 1. (211 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
RAP1BUncharacterized protein. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box O3. (672 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101024285Uncharacterized protein. (191 aa)
BEX3Brain expressed X-linked 3. (123 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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