STRINGSTRING
PTPRS PTPRS CSDE1 CSDE1 BAD BAD SOCS2 SOCS2 PPP1R3B PPP1R3B ELK3 ELK3 PDE3B PDE3B PRKACB PRKACB HRAS HRAS SHC2 SHC2 PIK3R1 PIK3R1 PHKA2 PHKA2 ENSPANP00000001773 ENSPANP00000001773 PPP1R14B PPP1R14B PRKAG1 PRKAG1 PPP1R3D PPP1R3D PIK3R3 PIK3R3 SOCS4 SOCS4 AKT3 AKT3 HK2 HK2 CBLB CBLB INPPL1 INPPL1 GYS1 GYS1 PRKAG3 PRKAG3 PPP1R3F PPP1R3F INS INS PDPK1 PDPK1 CRYGN CRYGN ARAF ARAF SORBS2 SORBS2 PPP1R3A PPP1R3A SORBS3 SORBS3 CBL CBL PRKAA2 PRKAA2 BMT2 BMT2 TMEM145 TMEM145 PIK3CA PIK3CA PRKCZ PRKCZ ACACB ACACB PIK3R2 PIK3R2 PRKAB1 PRKAB1 RHEBL1 RHEBL1 PRKAR2A PRKAR2A ENSPANP00000007612 ENSPANP00000007612 PRKCI PRKCI GYS2 GYS2 RPS6KB2 RPS6KB2 SOCS3 SOCS3 FOXO1 FOXO1 PTPRF PTPRF CALML3 CALML3 INSR INSR MYO9B MYO9B LOC100997022 LOC100997022 ENSPANP00000009247 ENSPANP00000009247 PPP1CA PPP1CA GEM GEM LIPE LIPE HK3 HK3 ELK1 ELK1 PRKAB2 PRKAB2 TRIP10 TRIP10 MAPK9 MAPK9 PRKAG2 PRKAG2 NRAS NRAS CALM3 CALM3 PHKG1 PHKG1 PRKAR2B PRKAR2B EIF4E1B EIF4E1B MAPK3 MAPK3 PHKG2 PHKG2 AKT1 AKT1 SREBF2 SREBF2 SOCS1 SOCS1 FLOT1 FLOT1 CEP152 CEP152 SHC4 SHC4 CALML4 CALML4 MYO9A MYO9A PTPN1 PTPN1 PIK3CD PIK3CD SH2B2 SH2B2 ALKBH4 ALKBH4 CALM1 CALM1 MTOR MTOR CRKL CRKL GRB2 GRB2 INPP5A INPP5A EXOC7 EXOC7 RPTOR RPTOR FASN FASN PRKAR1A PRKAR1A SOS2 SOS2 PYGL PYGL PYGB PYGB RHOQ RHOQ CRYBB3 CRYBB3 KIAA1671 KIAA1671 SOS1 SOS1 PPP1R3E PPP1R3E EIF4EBP1 EIF4EBP1 ERAS ERAS PPARGC1A PPARGC1A RHEB RHEB BRAF BRAF TSC1 TSC1 LOC101000688 LOC101000688 SHC3 SHC3 FBP2 FBP2 FBP1 FBP1 CRK CRK SLC2A4 SLC2A4 SREBF1 SREBF1 PRKAR1B PRKAR1B HKDC1 HKDC1 PPP1R3C PPP1R3C G6PC G6PC G6PC3 G6PC3 EFCAB13 EFCAB13 EFCAB3 EFCAB3 IRS2 IRS2 MAP2K1 MAP2K1 ENSPANP00000022451 ENSPANP00000022451 TSC2 TSC2 ENSPANP00000022909 ENSPANP00000022909 EIF4E2 EIF4E2 PKLR PKLR ENSPANP00000024582 ENSPANP00000024582 ENSPANP00000024626 ENSPANP00000024626 PHKA1 PHKA1 MAPK1 MAPK1 EIF4E EIF4E IRS4 IRS4 GSK3B GSK3B MKNK1 MKNK1 ENSPANP00000026850 ENSPANP00000026850 RPS6KB1 RPS6KB1 CALM2 CALM2 HK1 HK1 ENSPANP00000029629 ENSPANP00000029629 PCK2 PCK2 ENSPANP00000030371 ENSPANP00000030371 SORBS1 SORBS1 RRAD RRAD SH2B1 SH2B1 ENSPANP00000033457 ENSPANP00000033457 MAPK8 MAPK8 PIK3CB PIK3CB PHKB PHKB CALML6 CALML6 PPP1CB PPP1CB ENSPANP00000035568 ENSPANP00000035568 ENSPANP00000035911 ENSPANP00000035911 SHC1 SHC1 RAPGEF1 RAPGEF1 MAPK10 MAPK10 BUD23 BUD23 MAP2K2 MAP2K2 IKBKB IKBKB PYGM PYGM MKNK2 MKNK2 PCK1 PCK1 TBCA TBCA GCK GCK RAF1 RAF1 PVALEF PVALEF ACACA ACACA PTPRD PTPRD REM1 REM1 FLOT2 FLOT2 AKT2 AKT2 ENSPANP00000046240 ENSPANP00000046240 PPP1CC PPP1CC PRKAA1 PRKAA1 KRAS KRAS PRKACA PRKACA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
CSDE1Cold shock domain containing E1. (844 aa)
BADBCL2 associated agonist of cell death. (168 aa)
SOCS2Suppressor of cytokine signaling 2. (210 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
ELK3ETS transcription factor ELK3. (407 aa)
PDE3BPhosphodiesterase. (1117 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (338 aa)
HRASUncharacterized protein. (189 aa)
SHC2Uncharacterized protein. (567 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PPP1R14BUncharacterized protein. (207 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (340 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HK2Hexokinase 2. (917 aa)
CBLBCbl proto-oncogene B. (982 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1258 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (798 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SORBS2Sorbin and SH3 domain containing 2. (1200 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1138 aa)
SORBS3Sorbin and SH3 domain containing 3. (671 aa)
CBLCbl proto-oncogene. (918 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
TMEM145Transmembrane protein 145. (563 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
PIK3R2Uncharacterized protein. (721 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
RHEBL1RHEB like 1. (183 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
FOXO1Forkhead box O1. (655 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1913 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2157 aa)
LOC10099702240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
LIPELipase E, hormone sensitive type. (1051 aa)
HK3Hexokinase 3. (923 aa)
ELK1ETS domain-containing protein. (428 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
TRIP10Thyroid hormone receptor interactor 10. (601 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (413 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1272 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CEP152Centrosomal protein 152. (1706 aa)
SHC4SHC adaptor protein 4. (630 aa)
CALML4Calmodulin like 4. (194 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (465 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
SH2B2SH2B adaptor protein 2. (678 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
CALM1Calmodulin 1. (149 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (735 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
FASNFatty acid synthase. (2510 aa)
PRKAR1AUncharacterized protein. (381 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
RHOQRas homolog family member Q. (211 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
KIAA1671KIAA1671. (1815 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ERASES cell expressed Ras. (233 aa)
PPARGC1APPARG coactivator 1 alpha. (793 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
TSC1TSC complex subunit 1. (1168 aa)
LOC10100068840S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
SHC3SHC adaptor protein 3. (598 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (248 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
EFCAB13EF-hand calcium binding domain 13. (973 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
IRS2Insulin receptor substrate 2. (1316 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSPANP00000022451acidPPc domain-containing protein. (153 aa)
TSC2TSC complex subunit 2. (1810 aa)
ENSPANP00000022909SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (111 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
IRS4Insulin receptor substrate 4. (1250 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
ENSPANP0000002685040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (203 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CALM2Calmodulin 2. (149 aa)
HK1Hexokinase 1. (921 aa)
ENSPANP00000029629ETS domain-containing protein. (384 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
ENSPANP00000030371Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
ENSPANP00000033457Uncharacterized protein; Belongs to the calmodulin family. (99 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1083 aa)
CALML6Calmodulin like 6. (181 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (328 aa)
ENSPANP0000003556840S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (227 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
SHC1SHC adaptor protein 1. (601 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (297 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
MKNK2MAPK interacting serine/threonine kinase 2. (474 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
GCKPhosphotransferase. (480 aa)
RAF1Uncharacterized protein. (668 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ACACAAcetyl-CoA carboxylase alpha. (2389 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1930 aa)
REM1RRAD and GEM like GTPase 1. (515 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSPANP00000046240Uncharacterized protein. (352 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
Server load: low (14%) [HD]