STRINGSTRING
LOC100997529 LOC100997529 TYK2 TYK2 BAD BAD IRAK1 IRAK1 BIRC2 BIRC2 HSPA1L HSPA1L BCL2 BCL2 IFNG IFNG PPP1R14B PPP1R14B AKT3 AKT3 C7orf31 C7orf31 CASP9 CASP9 IL12B IL12B PDPK1 PDPK1 CCR5 CCR5 GNAI2 GNAI2 LAMB2 LAMB2 LAMA2 LAMA2 TGFB1 TGFB1 TRAF6 TRAF6 CASP8 CASP8 LOC101000981 LOC101000981 TGFB2 TGFB2 LAMA1 LAMA1 IL10RA IL10RA IL10 IL10 GNAI1 GNAI1 CASP3 CASP3 ENSPANP00000005546 ENSPANP00000005546 NFKBIB NFKBIB LAMA3 LAMA3 ENSPANP00000007612 ENSPANP00000007612 LOC101025906 LOC101025906 IRAK4 IRAK4 TNFRSF1A TNFRSF1A LOC103876580 LOC103876580 LAMC2 LAMC2 LAMB4 LAMB4 TLR2 TLR2 LDLR LDLR NFKB1 NFKB1 LAMA4 LAMA4 MAPK9 MAPK9 TNF TNF LY96 LY96 TAB2 TAB2 LAMB3 LAMB3 PIK3CG PIK3CG HLA-DOB HLA-DOB LOC101016766 LOC101016766 HLA-DPB1 HLA-DPB1 MAPK3 MAPK3 MAPK14 MAPK14 GNAO1 GNAO1 AKT1 AKT1 MAPK12 MAPK12 MAPK11 MAPK11 SOCS1 SOCS1 BIRC7 BIRC7 LAMA5 LAMA5 MYD88 MYD88 IFNGR1 IFNGR1 TGFB3 TGFB3 MAP2K6 MAP2K6 IFNGR2 IFNGR2 BCL2L1 BCL2L1 GNAI3 GNAI3 CD40 CD40 HLA-DPA1 HLA-DPA1 BIRC3 BIRC3 IL12A IL12A ITGA6 ITGA6 IL10RB IL10RB ENSPANP00000018830 ENSPANP00000018830 PIK3R5 PIK3R5 MAP2K3 MAP2K3 NOS2 NOS2 ALOX5 ALOX5 PPIF PPIF CHUK CHUK HLA-DQA1 HLA-DQA1 JAK1 JAK1 HSPA2 HSPA2 ENSPANP00000024582 ENSPANP00000024582 ENSPANP00000024626 ENSPANP00000024626 LOC101008579 LOC101008579 MAPK1 MAPK1 STAT1 STAT1 HLA-DQB1 HLA-DQB1 ENSPANP00000027970 ENSPANP00000027970 MAP3K7 MAP3K7 LOC101001669 LOC101001669 ENSPANP00000029069 ENSPANP00000029069 TAB1 TAB1 TLR4 TLR4 NFKBIA NFKBIA LAMC1 LAMC1 XIAP XIAP ITGB1 ITGB1 ENSPANP00000033499 ENSPANP00000033499 MAPK8 MAPK8 ENSPANP00000034491 ENSPANP00000034491 HLA-DOA HLA-DOA ENSPANP00000035911 ENSPANP00000035911 PIK3R6 PIK3R6 CD40LG CD40LG ENSPANP00000037158 ENSPANP00000037158 STAT3 STAT3 IRGM IRGM LOC101012154 LOC101012154 MAPK10 MAPK10 IKBKB IKBKB ENSPANP00000039953 ENSPANP00000039953 CIITA CIITA ENSPANP00000041867 ENSPANP00000041867 MAPK13 MAPK13 HLA-DMA HLA-DMA HSPA8 HSPA8 ENSPANP00000044216 ENSPANP00000044216 RELA RELA ENSPANP00000045653 ENSPANP00000045653 HLA-DRA HLA-DRA AKT2 AKT2 LOC100997503 LOC100997503 LOC101009667 LOC101009667 LOC101021327 LOC101021327 JAK2 JAK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100997529Cytochrome c. (105 aa)
TYK2Tyrosine-protein kinase. (1150 aa)
BADBCL2 associated agonist of cell death. (168 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
PPP1R14BUncharacterized protein. (207 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
LOC101000981Ig-like domain-containing protein. (242 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LAMA1Laminin subunit alpha 1. (3024 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
IL10Interleukin 10. (178 aa)
GNAI1G protein subunit alpha i1. (422 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ENSPANP00000005546Uncharacterized protein; Belongs to the heat shock protein 70 family. (635 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
LOC101025906Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TNFRSF1ATNF receptor superfamily member 1A. (459 aa)
LOC103876580Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
TLR2Toll-like receptor. (784 aa)
LDLRLow density lipoprotein receptor. (890 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LY96Lymphocyte antigen 96. (160 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
LOC101016766Ig-like domain-containing protein. (263 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAO1G protein subunit alpha o1. (354 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IFNGR2Fibronectin type-III domain-containing protein. (341 aa)
BCL2L1BCL2 like 1. (233 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CD40Uncharacterized protein. (262 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (267 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1088 aa)
IL10RBInterleukin 10 receptor, beta (Predicted). (325 aa)
ENSPANP00000018830Uncharacterized protein. (429 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (237 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (624 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
LOC101008579Cytochrome c. (105 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (281 aa)
ENSPANP00000027970Uncharacterized protein. (459 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC101001669Ig-like domain-containing protein. (247 aa)
ENSPANP00000029069Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (509 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (836 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSPANP00000033499Uncharacterized protein; Belongs to the heat shock protein 70 family. (563 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSPANP00000034491Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (746 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ENSPANP00000037158Uncharacterized protein; Belongs to the heat shock protein 70 family. (555 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IRGMImmunity related GTPase M. (159 aa)
LOC101012154Ig-like domain-containing protein. (295 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
ENSPANP00000039953Uncharacterized protein. (438 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
ENSPANP00000041867Uncharacterized protein. (129 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (638 aa)
ENSPANP00000044216Uncharacterized protein; Belongs to the heat shock protein 70 family. (547 aa)
RELARELA proto-oncogene, NF-kB subunit. (476 aa)
ENSPANP00000045653CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (195 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC100997503Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
LOC101009667Ig-like domain-containing protein. (279 aa)
LOC101021327Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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