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| | EGR2 | Early growth response 2. (415 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | TYK2 | Tyrosine-protein kinase. (1150 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | E2F2 | E2F transcription factor 2. (438 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | BCL2 | BCL2 apoptosis regulator. (238 aa) |
| | ENSPANP00000001773 | Uncharacterized protein. (189 aa) |
| | PPP1R14B | Uncharacterized protein. (207 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | C7orf31 | Chromosome 7 open reading frame 31. (590 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (416 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (235 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (282 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | JAK3 | Tyrosine-protein kinase. (1147 aa) |
| | CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa) |
| | LOC101023471 | Uncharacterized protein. (189 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (521 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | PIK3R2 | Uncharacterized protein. (721 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (461 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | TMED7 | Transmembrane p24 trafficking protein 7. (188 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4357 aa) |
| | ENSPANP00000007612 | Uncharacterized protein. (190 aa) |
| | LOC101025906 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 (Predicted). (470 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (930 aa) |
| | LOC103876580 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | ENSPANP00000009247 | Uncharacterized protein. (583 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (519 aa) |
| | ENSPANP00000009516 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | ENSPANP00000010220 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | MAP3K1 | Uncharacterized protein. (1508 aa) |
| | ELK1 | ETS domain-containing protein. (428 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (977 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ATF6B | Activating transcription factor 6 beta. (711 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | EP300 | E1A binding protein p300. (2427 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (246 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (321 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | BIRC5 | Uncharacterized protein. (144 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | E2F1 | E2F transcription factor 1. (423 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (349 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1042 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa) |
| | MMP9 | Matrix metallopeptidase 9. (707 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | RB1 | RB transcriptional corepressor 1. (889 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | IFNAR1 | Uncharacterized protein. (558 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (763 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (372 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (466 aa) |
| | JAK2 | Tyrosine-protein kinase. (1133 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | LOC101021327 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa) |
| | STAT2 | Signal transducer and activator of transcription. (855 aa) |
| | LOC100997503 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ENSPANP00000045653 | CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (195 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (476 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | LOC100997529 | Cytochrome c. (105 aa) |
| | TIRAP | TIR domain containing adaptor protein. (241 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (386 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | STAT5B | Signal transducer and activator of transcription. (791 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (422 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (446 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | ENSPANP00000039747 | Uncharacterized protein. (55 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (776 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | ENSPANP00000037027 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (244 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1147 aa) |
| | LOC101019008 | Uncharacterized protein. (198 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | E2F3 | E2F transcription factor 3. (460 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | ENSPANP00000030750 | Uncharacterized protein. (166 aa) |
| | ENSPANP00000030575 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (218 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (267 aa) |
| | ENSPANP00000030356 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (227 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (836 aa) |
| | ENSPANP00000029629 | ETS domain-containing protein. (384 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (509 aa) |
| | ENSPANP00000029069 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | STAT1 | Signal transducer and activator of transcription. (791 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ENSPANP00000025126 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (209 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | LOC101008579 | Cytochrome c. (105 aa) |
| | ENSPANP00000024626 | Uncharacterized protein. (82 aa) |
| | ENSPANP00000024582 | Uncharacterized protein. (147 aa) |
| | IL6 | Uncharacterized protein. (214 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | ENSPANP00000022606 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ENSPANP00000021624 | BZIP domain-containing protein. (322 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | FAS | Fas cell surface death receptor. (342 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
