STRINGSTRING
TYK2 TYK2 LOC100997246 LOC100997246 PSMC1 PSMC1 LOC101021327 LOC101021327 LOC101009667 LOC101009667 ENSPANP00000046574 ENSPANP00000046574 STAT2 STAT2 LOC100997503 LOC100997503 ENSPANP00000046336 ENSPANP00000046336 CD3E CD3E AKT2 AKT2 HLA-DRA HLA-DRA IRF9 IRF9 BTK BTK ENSPANP00000045653 ENSPANP00000045653 RELA RELA RUNX3 RUNX3 ENSPANP00000044663 ENSPANP00000044663 ENSPANP00000043887 ENSPANP00000043887 LOC100997529 LOC100997529 SKP2 SKP2 ENSPANP00000042759 ENSPANP00000042759 HLA-DMA HLA-DMA MAPK13 MAPK13 APAF1 APAF1 CR2 CR2 ENSPANP00000042342 ENSPANP00000042342 CD247 CD247 LOC101015730 LOC101015730 ENSPANP00000041596 ENSPANP00000041596 MAP2K7 MAP2K7 ENSPANP00000040203 ENSPANP00000040203 IFNA6 IFNA6 CDK2 CDK2 ENSPANP00000039524 ENSPANP00000039524 BAK1 BAK1 IKBKB IKBKB ENSPANP00000038680 ENSPANP00000038680 MAPK10 MAPK10 LOC101012154 LOC101012154 USP7 USP7 ENSPANP00000037790 ENSPANP00000037790 STAT3 STAT3 PSMD4 PSMD4 SIN3B SIN3B ENSPANP00000036982 ENSPANP00000036982 BAX BAX PACA-F PACA-F FCER2 FCER2 LOC101019008 LOC101019008 ENSPANP00000035552 ENSPANP00000035552 CD3D CD3D HLA-DOA HLA-DOA LOC101002482 LOC101002482 ENSPANP00000034651 ENSPANP00000034651 TAP2 TAP2 NEDD4 NEDD4 PIK3CB PIK3CB MAPK8 MAPK8 TP53 TP53 ENSPANP00000033198 ENSPANP00000033198 E2F3 E2F3 ENSPANP00000032731 ENSPANP00000032731 ENSPANP00000032024 ENSPANP00000032024 ISG15 ISG15 LOC101007932 LOC101007932 NFKBIA NFKBIA ENSPANP00000030750 ENSPANP00000030750 ENSPANP00000030153 ENSPANP00000030153 PSMD6 PSMD6 PSMD13 PSMD13 ENSPANP00000029353 ENSPANP00000029353 TAB1 TAB1 ENSPANP00000029162 ENSPANP00000029162 NCOR2 NCOR2 ENSPANP00000029069 ENSPANP00000029069 LOC101001669 LOC101001669 MAP3K7 MAP3K7 ENSPANP00000028312 ENSPANP00000028312 LOC101008637 LOC101008637 ENSPANP00000027932 ENSPANP00000027932 ENSPANP00000027602 ENSPANP00000027602 RBPJ RBPJ ENSPANP00000027020 ENSPANP00000027020 HLA-DQB1 HLA-DQB1 STAT1 STAT1 LOC101008579 LOC101008579 SNW1 SNW1 LOC101021633 LOC101021633 SEM1-2 SEM1-2 CIR1 CIR1 CD44 CD44 CDKN1B CDKN1B IL6 IL6 PSMD14 PSMD14 GADD45B GADD45B JAK1 JAK1 ENSPANP00000022457 ENSPANP00000022457 HLA-DQA1 HLA-DQA1 ITGAL ITGAL ENSPANP00000021653 ENSPANP00000021653 LOC101012738 LOC101012738 LOC101025045 LOC101025045 PSMC5 PSMC5 NFKB2 NFKB2 CHUK CHUK MAP3K14 MAP3K14 BLNK BLNK CC2D2B CC2D2B ENTPD1 ENTPD1 FAS FAS PSMD3 PSMD3 PSMD11 PSMD11 ENSPANP00000019978 ENSPANP00000019978 MAP2K3 MAP2K3 MAP2K4 MAP2K4 SYK SYK GADD45G GADD45G DDX58 DDX58 IFNAR1 IFNAR1 CC2D2A CC2D2A MDM2 MDM2 RB1 RB1 BCL2L11 BCL2L11 TRAF5 TRAF5 HLA-DPA1 HLA-DPA1 RBPJL RBPJL CD40 CD40 LOC101015220 LOC101015220 RELB RELB ENTPD8 ENTPD8 SAP30 SAP30 BID BID MAVS MAVS PSMC6 PSMC6 E2F1 E2F1 MAP2K6 MAP2K6 PSMD12 PSMD12 TRAF2 TRAF2 MYD88 MYD88 TNFAIP3 TNFAIP3 HDAC2 HDAC2 VIM VIM CCNA2 CCNA2 PIK3CD PIK3CD PDIA3 PDIA3 OSBPL2 OSBPL2 ADRM1 ADRM1 B2M B2M HLA-E HLA-E MAPK11 MAPK11 MAPK12 MAPK12 RIPK1 RIPK1 AKT1 AKT1 TRAF3 TRAF3 TRADD TRADD NFKBIE NFKBIE CCND3 CCND3 CDKN1A CDKN1A MAPK14 MAPK14 CD19 CD19 TAPBP TAPBP HLA-DPB1 HLA-DPB1 LOC101016766 LOC101016766 TAP1 TAP1 HLA-DOB HLA-DOB EIF2AK2 EIF2AK2 PSMC2 PSMC2 CCND2 CCND2 ENSPANP00000011803 ENSPANP00000011803 TAB2 TAB2 CDK6 CDK6 CCNA1 CCNA1 CD58 CD58 TNF TNF OAS3 OAS3 MAPK9 MAPK9 NFKB1 NFKB1 TLR2 TLR2 ENSPANP00000010471 ENSPANP00000010471 PLCG2 PLCG2 IFNB1 IFNB1 FADD FADD SIN3A SIN3A OAS1 OAS1 POLK POLK PSMC3 PSMC3 GADD45A GADD45A LOC103876580 LOC103876580 MYC MYC TRAC TRAC IFNAR2 IFNAR2 IRAK4 IRAK4 LOC101025906 LOC101025906 CDK4 CDK4 IRF3 IRF3 PSMD8 PSMD8 CCNE1 CCNE1 PIK3R2 PIK3R2 DDB2 DDB2 LOC101023471 LOC101023471 JAK3 JAK3 ENTPD3 ENTPD3 RAC1 RAC1 NFKBIB NFKBIB PSMC4 PSMC4 CASP3 CASP3 PSMD2 PSMD2 TBK1 TBK1 ICAM1 ICAM1 PIK3CA PIK3CA LOC101000981 LOC101000981 CASP8 CASP8 TRAF6 TRAF6 LYN LYN PSMD7 PSMD7 HDAC1 HDAC1 CCNE2 CCNE2 PSMD1 PSMD1 CASP9 CASP9 HES1 HES1 IKBKE IKBKE C7orf31 C7orf31 AKT3 AKT3 PIK3R3 PIK3R3 SAP30L SAP30L CXCL10 CXCL10 IRF7 IRF7 BCL2 BCL2 E2F2 E2F2 PIK3R1 PIK3R1 CD3G CD3G CALR CALR OAS2 OAS2 ENSPANP00000000964 ENSPANP00000000964 IRAK1 IRAK1 CCND1 CCND1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TYK2Tyrosine-protein kinase. (1150 aa)
LOC100997246Ig-like domain-containing protein; Belongs to the MHC class I family. (375 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (461 aa)
LOC101021327Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC101009667Ig-like domain-containing protein. (279 aa)
ENSPANP00000046574Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (452 aa)
STAT2Signal transducer and activator of transcription. (855 aa)
LOC100997503Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
ENSPANP00000046336AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
CD3ECD3e molecule. (198 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IRF9Interferon regulatory factor 9. (392 aa)
BTKTyrosine-protein kinase. (659 aa)
ENSPANP00000045653CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (195 aa)
RELARELA proto-oncogene, NF-kB subunit. (476 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
ENSPANP00000044663Ig-like domain-containing protein; Belongs to the MHC class I family. (348 aa)
ENSPANP00000043887Uncharacterized protein. (82 aa)
LOC100997529Cytochrome c. (105 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
ENSPANP00000042759AAA domain-containing protein; Belongs to the AAA ATPase family. (319 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CR2Complement C3d receptor 2. (1093 aa)
ENSPANP00000042342Ig-like domain-containing protein; Belongs to the MHC class I family. (397 aa)
CD247Uncharacterized protein. (165 aa)
LOC101015730MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (260 aa)
ENSPANP00000041596AAA domain-containing protein; Belongs to the AAA ATPase family. (416 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (446 aa)
ENSPANP00000040203Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
IFNA6Interferon alpha 6. (190 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSPANP00000039524IGc1 domain-containing protein; Belongs to the MHC class I family. (339 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
ENSPANP00000038680MHC_I-like_Ag-recog domain-containing protein. (137 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
LOC101012154Ig-like domain-containing protein. (295 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1099 aa)
ENSPANP00000037790Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PSMD4VWFA domain-containing protein. (380 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
ENSPANP00000036982AAA domain-containing protein. (402 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
PACA-FIg-like domain-containing protein; Belongs to the MHC class I family. (430 aa)
FCER2Fc fragment of IgE receptor II. (267 aa)
LOC101019008Uncharacterized protein. (198 aa)
ENSPANP00000035552Prot_ATP_ID_OB domain-containing protein. (166 aa)
CD3DCD3d molecule. (171 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
LOC101002482Ig-like domain-containing protein; Belongs to the MHC class I family. (404 aa)
ENSPANP00000034651CSN8_PSD8_EIF3K domain-containing protein. (249 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (703 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
ENSPANP00000033198Hist_deacetyl domain-containing protein. (225 aa)
E2F3E2F transcription factor 3. (460 aa)
ENSPANP00000032731Uncharacterized protein. (401 aa)
ENSPANP00000032024Ig-like domain-containing protein; Belongs to the MHC class I family. (370 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
LOC101007932MHC class I antigen; Belongs to the MHC class I family. (365 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ENSPANP00000030750Uncharacterized protein. (166 aa)
ENSPANP00000030153Ig-like domain-containing protein. (195 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (378 aa)
ENSPANP00000029353MHC_I-like_Ag-recog domain-containing protein. (152 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (509 aa)
ENSPANP00000029162Uncharacterized protein; Belongs to the AAA ATPase family. (402 aa)
NCOR2Nuclear receptor corepressor 2. (2519 aa)
ENSPANP00000029069Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
LOC101001669Ig-like domain-containing protein. (247 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSPANP00000028312Ig-like domain-containing protein; Belongs to the MHC class I family. (401 aa)
LOC101008637MHC_I-like_Ag-recog domain-containing protein. (170 aa)
ENSPANP00000027932MHC_I-like_Ag-recog domain-containing protein. (213 aa)
ENSPANP00000027602MPN domain-containing protein. (149 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (529 aa)
ENSPANP00000027020Hist_deacetyl domain-containing protein. (267 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (281 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
LOC101008579Cytochrome c. (105 aa)
SNW1SNW domain containing 1. (571 aa)
LOC101021633Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
SEM1-2Uncharacterized protein. (89 aa)
CIR1Corepressor interacting with RBPJ, 1. (374 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
IL6Uncharacterized protein. (214 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (237 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1204 aa)
ENSPANP00000021653Ig-like domain-containing protein. (170 aa)
LOC101012738Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa)
LOC101025045Ig-like domain-containing protein; Belongs to the MHC class I family. (435 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (409 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
BLNKB cell linker. (456 aa)
CC2D2BDUF5523 domain-containing protein. (1048 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa)
FASFas cell surface death receptor. (342 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (552 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSPANP00000019978Ig-like domain-containing protein. (153 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (466 aa)
SYKTyrosine-protein kinase. (635 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
DDX58DExD/H-box helicase 58. (925 aa)
IFNAR1Uncharacterized protein. (558 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
RB1RB transcriptional corepressor 1. (889 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (267 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (509 aa)
CD40Uncharacterized protein. (262 aa)
LOC101015220MHC class I protein; Belongs to the MHC class I family. (365 aa)
RELBRELB proto-oncogene, NF-kB subunit. (570 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
SAP30Sin3A associated protein 30. (220 aa)
BIDBH3 interacting domain death agonist. (244 aa)
MAVSMitochondrial antiviral signaling protein. (541 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
E2F1E2F transcription factor 1. (423 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (503 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
ADRM1Adhesion regulating molecule 1. (407 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (324 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (776 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
NFKBIENFKB inhibitor epsilon. (489 aa)
CCND3Cyclin D3 (Predicted); Belongs to the cyclin family. (292 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD19CD19 molecule. (558 aa)
TAPBPTAP binding protein. (503 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
LOC101016766Ig-like domain-containing protein. (263 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ENSPANP00000011803Ig-like domain-containing protein. (148 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
CD58CD58 molecule. (250 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1078 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
TLR2Toll-like receptor. (784 aa)
ENSPANP00000010471Ig-like domain-containing protein. (148 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IFNB1Interferon beta 1. (187 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SIN3ASIN3 transcription regulator family member A. (1197 aa)
OAS12'-5'-oligoadenylate synthetase 1. (488 aa)
POLKDNA polymerase kappa. (870 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC103876580Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
TRACT cell receptor alpha constant. (110 aa)
IFNAR2Interferon receptor 2, isoform 1 (Predicted). (516 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LOC101025906Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IRF3Interferon regulatory factor 3. (422 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (294 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PIK3R2Uncharacterized protein. (721 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
LOC101023471Uncharacterized protein. (189 aa)
JAK3Tyrosine-protein kinase. (1147 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
RAC1Rac family small GTPase 1. (211 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
TBK1TANK binding kinase 1. (729 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101000981Ig-like domain-containing protein. (242 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LYNTyrosine-protein kinase. (512 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (455 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SAP30LSAP30 like. (184 aa)
CXCL10C-X-C motif chemokine. (98 aa)
IRF7Interferon regulatory factor 7. (504 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
E2F2E2F transcription factor 2. (438 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CD3GCD3g molecule. (181 aa)
CALRCalreticulin. (417 aa)
OAS22'-5'-oligoadenylate synthetase 2. (727 aa)
ENSPANP00000000964AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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